THCA Shows Promise for Huntington’s Disease, Study Finds

Photo Credit: Leafly

Photo Credit: Leafly

In a new study published in the British Journal of Pharmacology, researchers have found THCA reduced inflammation, served as a neuroprotectant, improved motor function, and prevented brain degeneration in animals. THCA is the acidic precursor to THC, and is found in cannabis that has not yet undergone the heating process decarboxylation. THCA has the a lot of the same beneficial properties offered by THC, but without any psychoactive side effects. One thing that distinguishes THCA from other cannabinoids is its ability to positively affect the PPARy brain receptor, which is responsible for lipid metabolism and glucose homeostasis. This has led the study’s authors to believe THCA may serve “as a lead structure for the development of novel drugs for the management of (Huntington’s) and, possibly, other neurodegenerative and inflammatory diseases.” The authors find their study unique in that they are actively researching the acidic forms of cannabinoids, something that other studies often neglect. They explain most studies “have used neutral cannabinoids, especially THC and CBD… with little attention to the genuine phytocannabinoids of the plant, namely their acidic forms. We provide evidence that these compounds hold significant pharmacological potential.”

This information has been provided by Leafly and approve by our Chief Medical Officer.

Cancer Patients in Seattle Effectively Treat Symptoms with Cannabis

Photo Credit: Civilized

Photo Credit: Civilized

Information coming from the Fred Hutchinson Cancer Research Centre in Seattle has found of 926 patients at the Seattle Cancer Centre Alliance in Washington State, nearly a quarter self medicate with cannabis to treat symptoms like physical pain, nausea, stress, insomnia, and depression. In the study, which was published in the journal Cancer, 24% of patients used cannabis within the year, and 21% within the month. Around 66% had used it at some time in their lives. Three-quarters of those surveyed also expressed interest in learning about cannabis from reliable sources like healthcare professionals.

Investigators also found most patients were not receiving their information from healthcare professionals, leading researcher Dr. Steven Pergam to state, “Cancer patients desire but are not receiving information from their cancer doctors about marijuana use during their treatment, so many of them are seeking information from alternate non-scientific sources… We hope that this study helps to open up the door for more studies aimed at evaluating the risks and benefits of marijuana in this population ... This is important, because if we do not educate our patients about marijuana, they will continue to get their information elsewhere.”

This information has been provided by Civilized and approved by our Chief Medical Officer.

Survey Finds Coloradans Use Marijuana For Sleep and Pain Relief, Not Partying

Photo Credit: Civilized

Photo Credit: Civilized

With the wave of legalization gaining popularity in various states across the nation, it is interesting to see the motivations behind marijuana use. In Colorado, where both recreational and medical marijuana are legal, it seems even the recreational users are using marijuana to self medicate, as opposed to using it for fun. The organization Consumer Research Around Cannabis surveyed over 1,200 marijuana users in Denver and it surroundings, and found 47.2% used cannabis as a sleep aid. Another 47.2% used it for pain relief. Falling closely behind, 45.7% used marijuana for anxiety and depression. Only 28.5% used marijuana for recreational fun, and 32.8% responded they used marijuana for expanding creativity and thought processes.

This information has been provided by Civilized and approved by our Chief Medical Officer.

Study: Medical Cannabis Registrants Reduce Their Prescription Drug Use

Photo Credit: NORML

Photo Credit: NORML

Investigators from the University of New Mexico have recently published data suggesting chronic pain patients enrolled in a medical marijuana program are better able to reduce their use of prescription drugs than those who abstain from cannabis use. The study, which was published in the Journal of Post-Acute and Long-Term Care Medicine, analyzed the drug use patterns of 83 pain patients enrolled in a medical cannabis program and 42 patients who were not enrolled over the course of 24 months. Of those enrolled in the statewide medical marijuana program, 34% eliminated their prescription use by the end of the study, and 36% reduced their use of other medications. On average, registered medical marijuana patients significantly reduced their prescription medication intake, while non-registrants did not.

Authors concluded, “Legal access to cannabis may reduce the use of multiple classes of dangerous prescription medications in certain patient populations… [A] shift from prescriptions for other scheduled drugs to cannabis may result in less frequent interactions with our conventional healthcare system and potentially improved patient health.” This study supports similar findings from previous studies.

This study has been brought to you by NORML and approved by our Chief Medical Officer. You can also find the abstract here.

New Study: Marijuana with CBD Has Less Long-Term Risks Than Other Forms

Photo Credit: Civilized

Photo Credit: Civilized

Many people may desire the use of medical cannabis but fear any negative side effects. With cannabidiol (CBD) gaining in popularity for its high-safety profile and lack of psychoactive side effects, people wonder whether or not the cannabinoid is worth the hype. According to a new study, led by Dr. Ken Mackie from Indiana University, the answer is yes. In the study, scientists injected two groups of mice with tetrahydrocannabinol (THC), with one group only receiving the THC and the other also receiving CBD. Mice who received only THC experienced greater memory impairment and anxiety over the long term, while those who also received CBD did not experience these effects.

Previous studies surrounding THC and CBD have been mixed, but Mackie believes his study is more accurate because “this is the first study in a rigorously controlled animal model to find that CBD appears to protect the brain against the negative effects of chronic THC.” He continues to explain that this experiment "suggests that strains of cannabis with similar levels of CBD and THC would pose significantly less long-term risk due to CBD's protective effect against THC."

More research is left to be desired to understand how CBD is able to exhibit these effects. This information has been provided by Civilized and approved by our Chief Medical Officer.

Study: Trauma Patients Report Marijuana Helps Reduce Opioid Use

Photo Credit: the Daily Chronic

Photo Credit: the Daily Chronic

According to a new study from Harvard Medical School which was published in the Journal of Orthopaedic Trauma, patients who experience a musculoskeletal injury can effectively relieve pain symptoms and reduce their opioid use through the use of medical cannabis. In the survey, which involved 500 patients from a pair of orthopedic outpatient clinics, 90% of patients who reported using cannabis for recuperation within the past six months effectively reduced their pain, and 81% were able to reduce their use of opioids. Authors explained, “[I]n the subset of patients who used marijuana during their recovery, a majority indicated that it helped alleviate symptoms of pain and reduced their level of opioid intake.”

This information has been provided by the Daily Chronic and approved by our Chief Medical Officer.

Marijuana Exposure Associated With Improved Immunity in HIV Patients

Photo Credit: the Daily Chronic

Photo Credit: the Daily Chronic

A new study published in the journal Drug and Alcohol Dependence has determined patients with HIV who have tested positive for past cannabis exposure possess higher levels of CD4+ and CD8+, which are a subtype of white blood cells that can aid the immune process. Researchers from Virginia State University and the University of Florida Center for AIDS/HIV Research looked at differences in lymphocyte count among HIV patients who tested positive or negative for THC in urinalysis. Authors found, after adjusting for demographic and HIV-related covariates, those who tested positive for THC had significantly higher counts of CD4+ and CD8+. Authors conclude, “This preliminary study shows THC positive patients having better HIV-related immune levels than their negative counterparts, despite not being statistically different on various demographic HIV-related covariates. … The current findings suggest a potentially beneficial role to marijuana, additional to symptom palliation.”

This information has been brought to you by the Daily Chronic and approved by our Chief Medical Officer.

Study Finds Medical Marijuana Is Helping Kids with Cerebral Palsy

Photo Credit: High Times Magazine

Photo Credit: High Times Magazine

A new study conducted by Tikun Olam at the Wolfson Medical Canter near Tel Aviv, Israel, has found cannabis oil significantly reduced symptoms and improved motor skills, sleep quality, bowel movements and general mood in children suffering from Cerebral Palsy. The study, which started three years ago, involved 4o children between the ages 1-17 with high levels of motor disorders, of which 20 have completed testing, and the majority will continue medical marijuana use as an effective supplement alongside current medications. For the first two months, researchers looked for changes in each child’s condition before allowing them to receive medical marijuana. After two months of stability, the children received cannabis oil orally or through a feeding tube three times a day, as a supplement to their current medications. There were two types of oils containing different proportions of THC and CBD.

Researchers used indexes that evaluated medical marijuana’s effects on spasticity, dystonia, motor changes, mood, sleep, constipation, pain, and quality of life, and found after three to four months, the children’s conditions began to improve. They found medical cannabis to be safe with few side effects, and children experienced the strongest improvements, statistically, in motor function, followed by pain relief and improvements in sleep and bowel movements. They also found THC to be most effective for symptom relief, but because of its psychoactive effects, use CBD to buffer these effects. One of the research managers Lihi Bar-Lev Schleider explains, “The THC’s effect is especially relevant to motor function, whether it’s Parkinson’s disease or other motor symptoms… But the THC is also responsible for the psychoactive effect, so we picked a variety that also has a lot of CBD, which moderates the euphoric effect.”

Researchers now want to determine the most effective vehicle for administering the medication. This information has been provided by High Times and approved by our Chief Medical Officer.

Study Shows Marijuana Can Prevent Alzheimer's-Causing Protein From Developing

Photo Credit: Civilized

Photo Credit: Civilized

A new study conducted by David Schubert from the Salk Institute for Biological Studies in California has determined THC may prevent the formation of amyloid proteins which are thought to lead to Alzheimer’s. The study has found THC passes through the bloodstream and enters into the brain where it attaches to neuroreceptors and prevents plaques from forming. Schubert explains, “Although other studies have offered evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer’s, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells.”

This information has been provided by Civilized and approved by our Chief Medical Officer.

A Look at How Canadian Patients are Using Medical Marijuana

Photo Credit: Tilray

Photo Credit: Tilray

As access to medical marijuana continues to grow, but relatively little is known about how to properly dose the medication, it can be helpful to look at how patients have already been using the medication effectively. A 2017 study led by Philippe Lucas, the Vice President of Patient Research & Access at Tilray, and Nick Jikomes, PhD, in partnership with with researchers from the Cleveland Clinic, McMaster University, the University of British Columbia, and the University of Victoria, surveyed 2,032 medical marijuana patients across Canada. The median age of patients involved in the survey was 40, and men almost outnumbered women two to one. About 70% of users substituted medical cannabis for prescription medications, with most substitutions replacing opioids (36%), antidepressants (21%), and other pain medications. Lucas explains, “In 610 mentions of opioid medication, 59% of patients stopped using these painkillers completely, and another 18% cut their consumption to a quarter or less… This suggests that cannabis may already be playing a harm-reduction role in the current opioid crisis.” Patients (31%) also used cannabis to reduce tobacco use, and half of those respondents were able to quit tobacco use completely. Additionally, 44% of participants were able to reduce alcohol consumption, and 26% substituted cannabis for illicit drugs.

When it comes to specific conditions being treated with medical cannabis, 38% used cannabis to treat chronic pain, and 40% used cannabis to treat mental health issues, which included but is not limited to anxiety and insomnia. High-CBD strains were the most preferable strains, favored by 14.5% of respondents, and sought after by 50% of extract and concentrate customers. Among the variety of forms and vehicles of administration available to patients, the classic cannabis flower remained the most preferred form by a long shot. About 74% of patients used about a gram and a half of cannabis daily, and the majority of patients still preferred the traditional method of smoking the medication. That said, new methods of cannabis consumption are growing in popularity, ant 47% of patients preferred non-smoking methods of administration, with 31% of those respondents choosing to vaporize their medication. The least popular methods of administration were cannabis juicing, at .2% of respondents choosing this method, and topicals, with only .3% choosing this vehicle.

By journaling daily on the CannaBest Medical app, you are anonymously contributing the growing medical cannabis knowledge base and better understand how patients are using medical marijuana to treat symptoms. With this information, we can better understand how patients are precisely and effectively dosing their medical marijuana, which will offer guidance to other patients with their own regimens and will help physicians with their recommendation moving forward. We thank you for your participation, and hope you continue to use this tool daily so that, collectively, we can help others. This information has been provided in part by Leafly and Tilray, and approved by our Chief Medical Officer.

Study Suggests Higher CBD Levels Could Counteract Any Potentially Harmful Effects of Cannabis

Photo Credit: https://bit.ly/2Rhg2Jb

Photo Credit: https://bit.ly/2Rhg2Jb

Researchers from Indiana University have found equal parts THC and CBD can prevent memory impairment and prevent increased anxiety in mice. The new study has found that higher amounts of CBD could buffer against potentially harmful long-term effects associated with smoking marijuana. In the study, researchers injected mice everyday for three weeks with doses of either THC or CBD, THC and CBD, or neither cannabinoid. When only given THC, mice experienced increased anxiety and memory impairment. When they received equal parts THC and CBD, however, they did not exhibit the same side effects. Lead author Dr. Ken Mackie explains this information "suggests that strains of cannabis with similar levels of CBD and THC would pose significantly less long-term risk due to CBD's protective effect against THC.”

The adolescent and adult mice were divided into five groups, those who received THC only, those who received CBD only, those who received equal parts of both cannabinoids, those who received placebo, and those who received no treatment. Researchers observed immediate reactions after testing, and then tested them again six weeks later. Adolescent mice who received only THC exhibited negative symptoms six weeks later, while adult mice did not, suggesting teenagers may experience side effects that differ from adults. Equal doses of THC and CBD did not affect neither adolescent nor adult mice.

This information has been provided by Merry Jane and approved by our Chief Medical Officer.

Study Finds that People Who Use Marijuana Are Less Likely to Develop Diabetes and Obesity

Photo Credit: https://bit.ly/2vmeeU6

Photo Credit: https://bit.ly/2vmeeU6

New research coming from the University of Nebraska has determined marijuana may deter obesity and diabetes. In thousands of adults, both those who regularly use cannabis those who abstain, marijuana users did not have a higher body mass index despite consuming around 600 more calories per day. Additionally, when other factors like age, gender, and tobacco use were taken into account, marijuana users had smaller waist circumferences, better regulated insulin levels, and higher levels of good cholesterol. Even occasional marijuana users exhibited better overall health than those who abstained. The researchers were unable to determine the direct causal relationship as to why marijuana produced better health results, but think it could be related to marijuana’s ability to manage inflammation and provide neuroprotective effects and improve the metabolism.

This information has been provided by Civilized and approved by our Chief Medical Officer.

Cannabis Reduces Severity of Pancreatitis, Study Finds

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

According to a new retrospective study published in the journal Translational Gastroenterology and Hepatology, patients with a history of cannabis use experience less severe symptoms of acute alcoholic pancreatitis (AAP) than those who abstain from cannabis use. AAP produces acute bouts of abdominal pain, nausea, and vomiting in patients with progressive and irreversible damage to the pancreas gland caused by prolonged and extreme drinking. Researchers from the Mercer School of Medicine examined the severity of AAP in 116 patients by looking at blood urea nitrogen, bedside index for severity in acute pancreatitis (BISAP) score, systemic inflammatory response syndrome (SIRS), and Balthazar computed tomography (CT) scan grade, at the time they were admitted into a tertiary care teaching hospital between January 2006 and December 2015. Of those patients, 38 were identified as having a history of cannabis use, and 76 tested negative for THC. Patients were then matched based on their age and sex. Patients who tested positive for cannabis displayed less severe manifestations of AAP and were less likely to visit the ICU than those who tested negative.

Researchers explained, “[W]e found that cannabis positive patients had less severe presentation of AAP indicating that cannabis could modulate the inflammatory effects of alcohol on the pancreas.” These results support previous studies that suggested cannabinoids had anti-inflammatory effects on the pancreas, and that cannabinoids relieved pain associated with AAP. The researchers still conclude that further large scale studies are necessary to determine the effects cannabis has on AAP.

This information has been brought to you by Medical Marijuana Inc. and approved by our Chief Medical Officer.

Review: Marijuana Use Associated With Reduced Mortality

Photo Credit: The Daily Chronic

Photo Credit: The Daily Chronic

According to a scholarly review paper published by the biology department chair at the University of Indiana, South Bend, marijuana use has the potential to reduce rates of obesity, diabetes, opioid abuse, and other conditions that contribute to premature mortality. Authors estimate 23,500 of 47,500 annual premature deaths could be prevented if marijuana was legally regulated at a nationwide scale. This information has been provided by the Daily Chronic and approved by our Chief Medical Officer.

Study: No Link Between Cumulative Cannabis Use and Kidney Disease

Photo Credit: Sonya Yruel / Drug Policy Alliance

Photo Credit: Sonya Yruel / Drug Policy Alliance

Longitudinal data published in the Clinical Journal of the American Society of Nephrology has determined neither current nor long-term cumulative use of cannabis contributes to kidney disease. In the study, investigators from the San Francisco Veterans Affairs Medical Center and the University of California, San Francisco looked at the impact of past and current marijuana use over the course of ten years on estimated glomerular filtration rate (eGFR), which is a screening measurement that detects early kidney damage. Authors explained, “[O]ur findings did not demonstrate a longitudinal association between marijuana use and eGFR change, rapid eGFR decline, or prevalent albuminuria (the presence of albumin in the urine, typically as a symptom of kidney disease).”

This information has been provided by the Daily Chronic and approved by our Chief Medical Officer.

Can Marijuana Help Treat Asthma?

Photo Credit: Leaf Science

Photo Credit: Leaf Science

It may seem strange that inhaling medical marijuana may benefit those suffering from asthma, but its cannabinoids’ anti-inflammatory, anti-spasmodic, and anti-anxiety properties may offer therapeutic relief. Asthma is a condition in which the bronchioles of the lungs become inflamed, and in turn cause difficulties in breathing. Symptoms of the condition include shortness of breath, chest tightness, coughing, and wheezing. Although studies analyzing the effects of marijuana as an asthma treatment date back to the ‘70s, there is evidence to suggest that it can provide a powerful treatment option. In one study from 1974, investigators found smoked marijuana acted as a bronchodilator in asthma sufferers. Another study the following year, which was published in the American Review of Respiratory Disease, found marijuana containing 2% THC relieved symptoms of bronchospasms in healthy volunteers experiencing induced airway contractions that mimicked bronchospasms. The participants recovered immediately after smoking .5 grams of the 2% THC marijuana. Following studies found small doses of THC administered through an inhaled aerosol also served as a bronchodilator in patients with asthma.

Alongside THC’s success as a bronchodilator, CBD could also be helpful for asthma sufferers due to its ability to reduce the anxiety and stress that often contribute to asthma attacks. Its anti-inflammatory properties allow it to reduce inflammation in lung tissues and reduce the production of inflammatory compounds, known as cytokines, in the lungs. Additionally, one recent study from Brazil found CBD reduces mucosal production, something that is common in asthma. Lastly, a study from 2014 found THC and other cannabinoids reduce contractions in the lungs by acting on the CB1 receptors. The effect is dose-dependent, and symptoms were reduced by up to 39%. For best symptom relief, patients with asthma should avoid smoking due to the fact it is hot and irritating, and can result in further inflammation of the lungs. Additionally, while edibles can be helpful on a regular basis as a supplement or replacement for systemic steroids, its delay in effects make it impractical for patients seeking immediate relief. The best method for asthma sufferers may be vaporization. This allows patients to inhale the beneficial compounds of marijuana and experience immediate relief while avoiding the toxins found in marijuana smoke.

This information has been provided by Leaf Science and approved by our Chief Medical Officer.

Can Marijuana Help With Fibromyalgia?

Photo Credit: Leaf Science

Photo Credit: Leaf Science

Fibromyalgia is a condition that produces pain throughout the body and specific tender spots where the pain is characterized as deep tissue tenderness. Fibromyalgia patients also suffer symptoms similar to that of the flu, feeling fatigued and exhausted, or experiencing stiffness. Current treatments for fibromyalgia usually include exercise, cognitive behavioral treatment, mind-body awareness, and lifestyle changes, but now, some patients are looking to medical marijuana for symptom relief due to the fact it has been found to relieve pain, sleep disturbance, stiffness, mood disorders, and digestive disturbances. There are few controlled clinical studies revolving around marijuana use for fibromyalgia, but surveys have found fibromyalgia patients find medical marijuana effective for their symptoms. In a survey from Canada, one out of every eight people with fibromyalgia use marijuana or its cannabinoids for symptom relief. More men opted for marijuana than women, and marijuana users tended to be younger. Of the study’s participants, 77% of cannabis users were unemployed, leading researchers to theorize the marijuana was either ineffective at improving function, or patients who opted for marijuana were more severely affected by their symptoms from the beginning.

Another online survey of 1,300 fibromyalgia patients found 62% of patients who had tried marijuana had found it effective for treating their symptoms. The survey, which was conducted by the National Pain Foundation, also found that many sufferers claimed marijuana was the only option that helped provide symptom relief. In another survey, in which fibromyalgia sufferers were divided into groups of marijuana users and non-users, marijuana users smoked or ate marijuana not only to help with pain, but also to alleviate all of their other symptoms. Patients reported decreases in pain and stiffness and improved relaxation, sleep, and well-being, within two hours of dosing. Side effects were mild, but included dry mouth, dizziness, or sedation. Over 80% felt relief from sleeplessness. Lastly, a 2008 randomized trial published in the Journal of Pain found the administration of nabilone, which is a synthetic form of THC, improved pain and other symptoms in 40 fibromyalgia patients. A following study in 2010 found nabilone produced similar improvements.

This information has been provided by Leaf Science and approved by our Chief Medical Officer.

CBD Hemp Oil Beneficial for HPV Vaccine Side Effects, Study Suggests

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

A new study published in the Israel Medical Association Journal suggests CBD hemp oil could help reduce the symptoms and improved the quality of life for patients who suffer from adverse side effects like severe somatoform and dysautonomic sydrome after receiving HPV vaccination. Researchers entered the study with the notion that adverse side effects resulting from HPV vaccinations may be related to an imbalance in the endocannabinoid system. Authors of the study, who hailed from the University of Modena and the Reggio Emilia Medical School, wrote, “Due to the absence of a safe and effective therapy for these girls who were living with their families and having to deal with difficult conditions (such as emotional instability, social problems as well as school obligations), and suspecting that an endogenous cannabinoid network imbalance might be responsible for some of the described symptoms, we selected a natural therapeutic approach based on CBD-enriched hemp oil over a 3 month period in our Italian cohort.”

In the open-label study, 12 female patients between the ages 12 and 24 that had an adverse response to HPV vaccinations received sublingual CBD hemp oil drops over the course of three months. Each patient received 25 mg/kg daily, alongside 2-5 mg/ml CBD once a week, until they received the maximum dose of 150 mg/ml CBD per day. Researchers observed the oil presented, “significant benefits in the physical component score, vitality and social role functioning… This study demonstrated the safety and tolerability of CBD-rich hemp oil and the primary efficacy endpoint.” Two patients withdrew from the study claiming they experienced no benefits. While the results are hopeful, the researchers urge for blind clinical research to substantiate these results.

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer.

Cannabis Topicals: A Beginner’s Guide

Photo Credit: Leaf Science

Photo Credit: Leaf Science

Cannabis topicals refer to cannabis-infused products like lotions, creams, oils, and slaves, that are applied to the skin, and they’re gaining in popularity due to the fact they can target localized areas of the body for instantaneous symptom relief without producing psychoactive effects. With topicals, cannabinoids are absorbed through the skin before reaching the endocannabinoid system, where they interact with cannabinoids receptors, which happen to be abundant in our skin’s epidermal cells, mast cells, and sensory nerves. The effects of topicals generally last one or two hours and can be safely reapplied as much as needed, but patients should be aware of any other ingredients included in the topical so as to avoid any sensitivity or allergic reactions.

The reason topicals produce localized and non-psychoactive effects as opposed to effects that influence the whole body is that the skin is a difficult barrier to penetrate, thereby preventing cannabinoids from entering the blood stream and flowing throughout the body. Dr. Ethan Russo, MD, explains, “THC and CBD work through independent mechanisms in a complementary fashion,” says Dr. Russo. “Both work well on the skin, but are poorly absorbed via this route… The skin is a difficult barrier to broach with medications…There are layers that require a drug to be water-soluble and others that must be lipid (fat) soluble. Cannabinoids are lipophilic (fat-loving) and do not penetrate readily into the bloodstream.”

Topicals are most commonly used to reduce pain and inflammation, and treat the symptoms of various skin conditions, like psoriasis and dermatitis. One study from 2009 published in the journal Experimental Dermatology suggested cannabinoids have immunosuppressive properties that could make it powerful as an anti-inflammatory drug, and that when administered topically, cannabis produces pain relief and antipruritic effects that reduces itching sensations. Americans for Safe Access also references anecdotal reports on the efficacy of topicals for treating superficial wounds, herpes, hemorrhoids, menstrual pains, migraines, and more.

This information has been provided by Leaf Science and approved by our Chief Medical Officer.

What is CBN (Cannabinol)?

Photo Credit: Wikimedia Commons

Photo Credit: Wikimedia Commons

Cannabinol (CBN) is one of the 113 identified therapeutic cannabinoids found in marijuana, which not only interacts with the endocannabinoid system to provide its own unique effects, but which also boosts the effects of other cannabinoids like CBD and THC. Because CBN does not fit well with CB1 receptors and has difficulty binding with CB2 receptors, CBN produces only minor psychoactive effects if produced at all. CBN is present in cannabis in very small proportions, and is produced by the degradation of THC after exposure to high temperatures or after aging in improper storage. Researchers have found CBN has strong antibacterial properties, and in one study it showed strong antibacterial effects against strains of antibiotic-resistant MRSA. CBN may also act as an anticonvulsant, although other cannabinoids like CBD remain more potent as an anticonvulsant. CBN may combat inflammation by influencing immune cells to produce anti-inflammatory effects and by altering levels of the compounds that cause inflammation.

Cannabinol may also increase appetite, according to rodent models in which rats receiving CBN ate larger amounts of food for longer periods of time and more frequently. In Lewis lung carcinoma, researchers have found CBN is effective at reducing tumor growth. CBN may also be effective at reliving pain through stimulating the release of peptides from sensory nerves, which decreases sensations of pain. When combined with THC, CBN may be able to enhance effects of sedation and promote more effective sleep. CBN may also act as a vasorelaxant, so that it relaxes blood vessel walls and thereby lowers blood pressure. Lastly, CBN may recruit stem cells from bone marrow to help heal bones. CBN increases fibroblast cells, making it beneficial for the bone-healing process.

This information has been provided by Leaf Science and approved by our Chief Medical Officer.