What Are The Medical Benefits of Marijuana? - Part 3.

Photo Credits: Leaf Science

Photo Credits: Leaf Science

In the last post, we continued to look at the conditions where medical marijuana is effective. It’s not done yet! We’ll continue the discussion below.

While the relationship between marijuana and heart disease is complicated, and cannabis can actually exacerbate symptoms in some users by increasing heart rate and blood pressure, scientists have found low doses of THC can reduce damage from heart attacks, and CBD can be used as a treatment for cardiovascular disease. Cannabis may also reduce the severity and lessen the impact of a stroke. Although most studies thus far have been animal studies, researchers believe medical cannabis may help treat the symptoms of Huntington’s disease, and one human study found synthetic THC improved motor-related symptoms of the disorder. Animal studies have found cannabis may slow the progression of Amyotrophic lateral sclerosis, and many properties of cannabis could help reduce pain, relax muscles, reduce saliva, stimulate appetite, and induce sleep. Synthetic cannabinoids also improved pain symptoms in fibromyalgia patients, and one survey found patients actually preferred cannabis to any approved pharmaceutical medication.

New support is starting to accumulate for the use of marijuana for Alzheimer’s disease. Marijuana may be able to do so by reducing inflammation and the formation of plaques. Marijuana has been found to alleviate tics and be well tolerated in patients with Tourette’s syndrome. Cannabis topicals are now offered as effective treatments for varying skin disorders, and its anti-inflammatory and anti-itching properties make it effective for the treatment of acne, dermatitis, and psoriasis. Marijuana may also help those who suffer from sleep disorders like insomnia and sleep apnea fall asleep quicker and improve breathing during sleep. Lastly, and probably most well known, is medical marijuana’s ability to treat epilepsy. Specifically, the cannabinoid CBD is well-tolerated and effective in reducing the frequency and severity of seizures.

There are even many more conditions to talk about regarding medical marijuana treatment. Keep reading as we conclude our discussion in the next post! This information has been provided by Leaf Science and approved by our Chief Medical Officer.

Cannabinoids Improve Speech In Patients With Tourette Syndrome

Photo Credit: The Daily Chronic

Photo Credit: The Daily Chronic

A study published in The International Journal of Molecular Sciences has determined the daily use of cannabinoids may improve speech fluency in patients diagnosed with Tourette Syndrome. Researchers from the Hannover Medical School in Germany looked at the impact of daily cannabinoid treatment in two patients with treatment-resistant vocal blocking tics, with one patient using THC-dominant whole-plant cannabis and the other using dronabinol (oral THC). Both treatments produced “significant improvement not only of simple and complex motor and vocal tics, but also in the overall symptomology including comorbid conditions and most importantly significantly improved patients’ quality of life including their social contacts and performance at school without side effects.” While this study is small, it supports previous studies that have found inhaled cannabis or oral synthetic THC improve the symptoms associated with Tourette syndrome. More research is left to be desired, but the researchers claim, “[C]annabis-based medicine appears to be effective in treatment-resistant TS patients with vocal blocking tics.”

This information has been provided by The Daily Chronic and approved by our Chief Medical Officer.

Cannabis Could Treat Tourette Syndrome: Study

Photo Credit: Civilized

Photo Credit: Civilized

A new study coming out of the University of Toronto suggests that cannabis may be an effective alternative treatment option for Tourette's symptoms. In the study, which was led by Elia Abi-Jaoude and published in the Journal of Neuropsychiatry and Clinical Neurosciences, researchers found 18 of 19 participants who used cannabis routinely for over two years saw significant improvements in symptoms. While the study is hopeful, it could have benefited from a larger sample size, more consistency in cannabis strains, and placebo control. Abi-Jaoude hopes to take this study further, using controlled and double-blind methods along with various cannabis strains. Still, Abi-Jaoude believes cannabis shows promise as a treatment for tics and other Tourette's-related symptoms.

This information has been provided by Civilized and approved by our Chief Medical Officer. 

Cannabinoids Found Beneficial in Treatment of Tourette Syndrome

Photo Credit: MassRoots

Photo Credit: MassRoots

Neuropsychological studies have found high concentrations of CB1 receptors in areas of the brain that are linked to cognitive functions, suggesting it could influence areas that are effected by neuropsychiatric disorders like Tourette syndrome, a condition characterized by involuntary and repetitive movement, and vocal and phonic tics. Two studies have found THC have validated that use of THC for the treatment of Tourette related symptoms when other treatment options have failed. The cannabinoids may be able to treat stimulant-induced exacerbation of tics and related co-morbidities through its enhancement of intra-cortical inhibition and its induction of neurotransmitter release. Cannabinoids can also treat the behavioral symptoms of tics by modulating the brain's neurotransmitter systems. One review led by German researchers found a 25 year old male patient suffering from Tourette syndrome successfully treated his symptoms using a single dose of 10 mg of THC. Unfortunately, this study was open-labeled and uncontrolled. 

One double-blind, randomized single-dose and placebo-controlled study found THC safely and effectively reduces tics and related behavioral disorders like obsessive compulsive behaviors (OCB). 12 patients with Tourette syndrome were treated with either 5.0, 7.5, or 10.0 mg of THC, and researchers and patients reported significant improvements in tics and OCB in comparison to the group receiving placebo. The severity score dropped from 41 to 7 within only two hours of administration, and the relief lasted several hours without producing adverse side effects other than what was considered minor psychoactive effects. Plasma analysis indicated a relationship between higher 11-OH-THC plasma concentration and tic improvement. One follow-up study involving 24 patients with Tourette syndrome found patients who received 10 mg THC for 6 weeks experienced clinically significant reductions in tics. The other follow-up and cross-over study, which involved 12 patients who received a single dose 10 mg THC, reported significant improvements in the treated group in comparison to the placebo group without producing side effects. 

This information has been provided by MassRoots and approved by our Chief Medical Officer. 

 

Medical Marijuana for Tourette Syndrome

Photo Credit: Pixabay (https://bit.ly/1DpRO2I

Photo Credit: Pixabay (https://bit.ly/1DpRO2I

Tourette syndrome is a disorder of the nervous system that develops during childhood and is characterized by simple or complex involuntary motor or vocal tics. There is no known cure for the disorder, so treatments focus on managing its symptoms and tics, and studies have found cannabis safely and effectively reduces the frequency of tics. Research has found cannabis suppresses tics and benefits the behavioral problems associated with Tourette syndrome. One study found single cannabis treatments on adults with Tourette syndrome found improvements in tics and obsessive-compulsive behavior in comparison with a placebo.

Another study found six weeks of cannabis treatment significantly reduced tics in Tourette's patients when compared to a placebo. Another study of the same duration found cannabis not only reduced tics, but it did so without producing adverse side effects or impairing neuropsychological performance. Additionally, these treatments have not been shown to impair verbal and visual memory, reaction time, intelligence, sustained attention, divided attention, vigilance or compared to placebo treatment, suggesting there are no acute or long-term cognitive effects associated with cannabis treatment. 

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

Cannabis May Help Treat Tourette Syndrome

Photo Credit: Marijuana Times

Photo Credit: Marijuana Times

Tourette Syndrome is known for producing involuntary and repetitive movements and vocal or phonic tics in patients. This could be anything from uncontrolled jaw movements, blinking, facial movements, shrugging, jerking about, stretching, hooting, throat clearing, or producing unrecognizable or inappropriate sounds. There is no cure available for Tourette Syndrome, but evidence suggests cannabis may be able to offer some relief. Because the CB1 receptor is densely present in layers of the cerebellum, basal ganglia and hippocampus, it could play an important role in relieving certain tics. In two separate studies from 2003 and 2013, delta-9-THC was viewed as an acceptable treatment of Tourette Syndrome when conventional therapies were ineffective or detrimental.

Cannabinoids also modulate brain neurotransmitter systems, making it possible to treat Tourette Syndrome or reduce symptoms of tics. In one double-blind, placebo-controlled, randomized single-dose study, researchers sought to investigate the safety and efficacy of different doses of THC in 12 Tourettes Syndrome patients. They assessed tic severity using Tourette Syndrome Symptom List, cross-checking with different clinical examiners' rating scales and assessing other behavioral disorders. The maximum plasma concentrations of THC were correlated with the clinical improvements or changes. Researchers saw improvements in motor, vocal, and complex motor tics and obsessive compulsive behavior disorder. The severity score even dropped from 41 to 7 within two hours of delta-9-THC administration, with relief lasting several hours. The treatment did not cause adverse events aside from mild occurrences of psychoactive side effects. Followup studies confirmed these results.

This information has been provided by Marijuana Times and approved by our Chief Medical Officer. 

New Research Says Cannabis Can Treat Tourette Syndrome

Photo Credit: Jeff Standley

Photo Credit: Jeff Standley

According to research conducted by the Department of Psychiatry at the Tauranga Hospital in New Zealand, cannabis may be able to treat the severe motor and vocal tics associated with Tourette syndrome. The study examined the effects of a whole plant cannabis extract made by GW Pharmaceuticals called Sativex in one patient suffering from Tourette syndrome. Twice daily over the course of four weeks, doctors gave the patient controlled doses of Sativex, an oromucosal spray that administers 10.8mg of THC and 10 mg CBD. They then measured the perceived severity of the tics. The patient and objective observers noted a "marked improvement in the frequency and severity of motor and vocal tics post-treatment."

While this data provides hope for future treatment methods of Tourette syndrome, the study is too small of a scale to suggest anything definitive about the best treatment methods and dosing information for treating the condition with medical cannabis. This is why we at CannaBest Medical can't stress enough the importance of journaling on a daily basis. In doing so, you are becoming an anonymous member of a patient pool that contributes vital data that can inform researchers and physicians about the most effective and ineffective ways of using medical marijuana to treat your unique condition. With more participants and information, we can better assess the true value of this medication. 

This information has been brought to you in part by High Times Magazine and approved by our Chief Medical Officer.