Cannabinoid Receptor-1 (CB-1) & THC

Photo Credit: High Times

Photo Credit: High Times

We know that the cannabinoids in cannabis are able to produce their therapeutic relief by interacting directly or indirectly with the cannabinoid receptors found within the endocannabinoid system, but how exactly does this work? Well, for the cannabinoid tetrahydrocannabinol (THC), the chemical can bind directly the cannabinoid receptor-1 (CB-1). The CB-1 receptor is part of a class of proteins called the g-protein coupled receptors (GPCRs), which are responsible for managing cellular signal transduction to communicate between cells. The proteins are so important, in fact, that they account for 60% of drug targets. The CB-1 receptor is involved in combating varying diseases and abnormalities, including Alzheimer’s, epilepsy, and obesity.

Researchers have recently discovered that their are two types of agonists that bind to and activate the CB-1 receptors, one being very similar in structure to THC. With this information, we will not only be able to better understand how the receptor moves, but also why THC and other cannabinoids are able to produce such positive effects within the body.

This information has been provided by High Times and approved by our Chief Medical Officer.

Cannabinoid Receptor-1

Photo Credit: High Times Magazine

Photo Credit: High Times Magazine

Scientists recently identified the structure of the cannabinoid-1 receptor, which is the receptor of the endocannabinoid system responsible for binding with THC. The CB1 receptor is classified as a GPCR protein, which is the most common class of receptor proteins in our body and of which 40% of drugs are developed to target. Technological advancements in X-Ray crystallography have allowed scientists to develop CB1 crystals. With this new information, scientists will be able to understand how THC binding affects the protein differently from other binding partners, and how the receptor functions at an atomic scale so that they can better understand its role in the treatment of diseases like epilepsy and obesity.

This information has been provided by High Times Magazine and approved by our Chief Medical Officer. 

Scientists Give Us the First Look at Cannabinoid Receptors in the Brain

Photo Credit: Getty

Photo Credit: Getty

With a recent and groundbreaking discovery, scientists now have a better understanding of the endocannabinoid system and have found insights as to how cannabinoid receptors work. By essentially freezing the CB1 receptor temporarily, scientists were able to study and learn about its molecular structure long enough to develop a 3-D model of it. This breakthrough can allow us to gain a better idea of how cannabinoids bind to certain receptors, and better understand why certain cannabinoids and synthetic cannabinoids offer therapeutic relief while others cause adverse side effects. This information will allow doctors to effectively and efficiently target receptors so they can provide specific symptom relief.

This information has been provided by Marijuana Times and approved by our Chief Medical Officer.