Does Tetrahydrocannabivarin (THCV) Get You High?

Photo Credit: Civilized

Photo Credit: Civilized

Following up on our post discussing the benefits of the cannabinoid THCV, some might want to know how severe its psychoactive effects are. THCV does produce psychoactive and physiological effects, but these effects differ from the effects most people have come to understand produced by THC. Although everyone may experience a different reaction, THCV is generally thought to provide a stimulating, clear-headed buzz as well as mental energy. THCV intensifies the cerebral euphoria caused by THC, which could end up causing anxiety in some users. At the same time, however, THCV may have the ability to counteract the negative effects of THC, like paranoia, impaired short-term memory, and increased heart rate. Unlike THC, the side effects of THCV do not produce increased appetite. Instead, it is an appetite suppressant. The onset of THCV’s psychoactive effects is quicker than that of THC, but it only lasts half as long.

Patients who want to avoid psychoactive effects altogether may want to steer clear of THCV. For those who would like to experience the benefits discussed in the previous post may want to titrate strains containing THCV into their dose, beginning with low doses, so that they can understand how the cannabinoid affects their body. Our app can help, and by journaling daily you can document the experience of your new dosing regimen to monitor what works and what doesn’t, so you can discover optimal relief. This information has been provided by Civilized and approved by our Chief Medical Officer. This post does not represent an endorsement on behalf of Civilized for CannaBest Medical.

What Are the Benefits of Tetrahydrocannabivarin (THCV)?

Photo Credit: Civilized

Photo Credit: Civilized

The cannabinoid tetrahydrocannabivarin (THCV) is a psychoactive and stimulating compound that may offer a wide variety of benefits. THCV may be able to help those with anxiety, especially when it comes to counteracting the mental stress brought on by the cannabinoid THC. THCV has been known to help relieve panic attacks and treat PTSD without affecting emotions. THCV may also promote bone cell growth and bone health, which means it could be beneficial for those suffering from osteoporosis or other similar conditions. Because THCV is an antioxidant, it could provide neuroprotective benefits that would help those with Parkinson’s disease and other neurodegenerative diseases. THCV’s ability to suppress the appetite make it ideal for those trying to lose weight, so those trying to stimulate appetite should avoid the strains containing too much THCV. Patients with diabetes may want to find strains with THCV because it regulates blood sugar levels and reduces insulin resistance. Lastly, early research has shown THCV has the potential to improve motor control, reduce tremors, and lessen the damage from brain lesions caused by Alzheimer’s.

This information has been provided by Civilized and approved by our Chief Medical Officer.

For Weight Loss, Stick to THCV-potent Cannabis Strains

Photo Credit: MassRoots

Photo Credit: MassRoots

Researchers have found the cannabinoid tetrahydrocannabivarin (THCV) can act as a dietary compound that suppresses appetite and provides energy. The cannabinoid also reduces insulin resistance, making it beneficial for patients who suffer from Diabetes. One study from 2013 coming from the University of Buckingham found oral doses of THCV, when given to groups of genetically obese and dietary-induced mice, improved insulin signaling and sensitivity.

THCV is non-psychoactive at small doses, and while it does stimulate the brain in similar ways to THC in high doses, the effects do not last long. Steep Hill, a cannabis science and technology firm, suggests THCV can aid in panic attacks, anxiety, and stress without affecting one's emotions, something that could be beneficial for patients with PTSD. Patients with Parkinson's disease may also benefit from THCV's effects on motor control. Scientists believe THCV may also stimulate bone growth, which could help those with osteoporosis. Lastly, like CBD, THCV produces anti-inflammatory effects. 

To learn more about this cannabinoid and where you can find THCV-potent strains, read the full article on MassRoots. This information has been approved by our Chief Medical Officer. 

Clinical Trial: THCV Lowers Blood Sugar Levels In Type 2 Diabetics

Photo Credit: The Daily Chronic

Photo Credit: The Daily Chronic

Data published in the journal Diabetes Care suggests THCV is positively associated with glycemic control in type 2 diabetes. In the randomized and placebo-controlled study, investigators from the University of Nottingham, School of Medicine administered placebo or different cannabinoids, like CBD, THCV, or a combination of the two, twice a day over the course of 13 weeks to 62 non-insulin dependent participants with Type 2 diabetes. THCV alone decreased fasting plasma glucose levels and improved pancreatic cell function. Other treatments offered undistinguishable metabolic effects. The study concluded, “THCV could represent a new therapeutic agent in glycemic control in subjects with type 2 diabetes.”

This information has been brought to you by the Daily Chronic and approved by our Chief Medical Officer. 

Study Finds: THCV Buffers THC

Photo Credit: Whaxy

Photo Credit: Whaxy

THCV, or tetrahydrocannabivarin, is molecularly similar to THC, and both molecules fit into the same receptors in the central nervous system and immune system, but THCV does not offer the same intense psychoactive effect that THC is known for producing. While THCV may not be very well known, it is actually one of the more common cannabinoids, and can make up almost half of the cannabinoids by volume in certain strains of cannabis. THCV is not lacking in medical efficacy, and it is suggested it can offer relief for a variety of conditions, including epilepsy and PTSD. THCV is also being studied as a potential therapy for treating obesity and related eating disorders because it acts as an appetite suppressant.

Now, evidence suggests that THCV also acts as a buffer for the psychoactive effects of THC. A new study published in 2015 in the Journal of Psychopharmacology found THCV was able to buffer adverse side effects of THC, like reducing paranoia, decreasing memory impairment, and preventing rapid increases in heart rate. The study also found patients could not discern a difference between THCV and a placebo, meaning THCV does not carry the psychoactive effects of THC.

As states legalize medical marijuana and research advances, we are learning much more about the synergistic interactions among the many cannabinoids in cannabis. This information has been provided by Whaxy and approved by our Chief Medical Officer. 

Cannabis for Nausea and Vomiting

Photo Credit: Whaxy

Photo Credit: Whaxy

One of the well known healing properties of cannabis is its ability to reduce nausea and vomiting, something that is especially useful for cancer or HIV/AIDs patients undergoing chemotherapy or radiation therapy. Patients experiencing nausea or vomiting don't have much of an appetite, so cannabis' ability to stimulate appetite is also beneficial in targeting nausea and vomiting. While pharmaceutical medications have evolved over time to effectively target nausea and vomiting symptoms, they are generally much more expensive than marijuana and often carry negative side effects that marijuana does not. 

Whaxy stresses the need for more research, but says the studies that do exist show indica strains that contain a lot of the terpene myrcene are especially effective in reducing nausea and stimulating appetite. A 2013 study published in the British Journal of Pharmacology analyzed the effects of the cannabinoids THCV and CBDV in rodents with toxin-induced nausea. The author, concluded both cannabinoids “may have therapeutic potential in reducing nausea.” A review of these studies also suggested THC was able to stimulate appetite in cancer and HIV/AIDS patients.

Another study from the Michigan Department of Health in 1982 looked at 165 cancer patients undergoing chemotherapy who sought to alleviate nausea and vomiting. The participants were divided into groups, one using cannabis and the other using the pharmaceutical drug Torecan. Patients could elect to switch to the other group if they found their treatment ineffective. Of those receiving cannabis, 90 percent continued its use. Out of the 23 patients who received Torecan, 22 opted to switch to cannabis instead. "The study concluded that 71 percent of the patients who received cannabis reported no vomiting and only moderate nausea following chemotherapy treatment."

In today's cannabis culture, there are a wide variety of methods for consuming cannabis, but not all are recommended for patients suffering nausea and vomiting. Edibles are not the preferred method for combatting these symptoms because of the time it takes to take effect. Vaporization is great because of the rapid onset of relief and it is a healthier option than smoking, but for those with respiratory illnesses as well, this method is not ideal. Luckily, for those who need quick relief but do not want to inhale their medication, tinctures or pills are available. 

Visit Whaxy for a deeper look at cannabis and nausea and vomiting, including anecdotal testimonies, an array of clinical studies, and a list of recommended strains for combatting these symptoms.  

Cannabis for the Treatment of Diabetes

Photo Credit: Whaxy

Photo Credit: Whaxy

Those who suffer from diabetes constantly have to watch what they eat and check their blood sugar levels. This is because diabetes, also known as hyperglycemia, is a disease in which the body cannot process food into energy use properly, so blood glucose levels rise higher than normal. Whaxy lists the symptoms of diabetes as "chronic fatigue, frequent urination, excessive thirst, unexplained weight loss, extremem hunger, sudden vision changes, tingling or numbness in hands or feet, very dry skin, sores that are slow to heal, and more infections than usual." When diabetes advances, it can precede heart disease, blindness, kidney failure, and lower-extremity amputations. Diabetes can also be fatal, and approximately 76,000 Americans die from diabetes annually, making it the seventh leading cause of death in the United States.

Diabetes is categorized as either Type 1 or Type 2. Type 1 diabetes is only responsible for 5% of all cases of diabetes, and only afflicts children and young adults. Type 2 diabetes is much more common, and those who develop Type 2 diabetes suffer from insulin resistance in which they cannot use insulin properly. Metabolic syndrome is a variety of Type 2 diabetes resulting from the combination of obesity, high blood pressure, and diabetes. This syndrome increases risks of developing heart disease or undergoing a stroke.

In 2005, the American Alliance for Medical Cannabis published a research paper detailing the ways in which cannabis can help diabetic patients. Some of the benefits include cannabis' ability to "stabilize blood sugars, act as an anti-inflammatory, act as a vasodilator, lower blood pressure, relieve neuropathic pain and tingling, relieve restless leg syndrome, and improve sleep." Some diabetics develop something called diabetic retinopathy which can result in blindness. It is believed cannabis can significantly decrease eye pressure, and therefore relieve the symptoms of this condition. In addition, cannabis' anti-inflammatory properties can relieve arterial inflammation found in many diabetics.

Research published by GW Pharmaceuticals in England in 2012 revealed the cannabinoid THCV was able to increase sensitivity to insulin and protect cells that make insulin in animals. In addition, THCV and CBD were able to boost the animals' metabolism in order to reduce fat in their livers and cholesterol. Both of these effects would be highly beneficial in for diabetics who need to regulate their insulin and maintain healthy body weight. 

While many conventional pharmaceuticals adequately relieve the symptoms of diabetes, many also pose the risk of negative side effects like suppression of the immune system, or liver and kidney damage. Because cannabis offers symptom relief to diabetics without these negative side effects, the plant is worth further investigating. Read more about cannabis for the treatment of diabetes on Whaxy

ALS and Medical Marijuana

You may know ALS as Amyotrophic Lateral Sclerosis. You may know ALS as Lou Gehrig's Disease. Or, you may know ALS because of the ALS Ice Bucket Challenge, the recent social media trend that brought the condition to the public eye. However you think of the neurological condition, everyone knows ALS for its ability to affect a person's motor function in the muscles of organs and limbs. Symptoms of the condition include muscle weakness, muscles spasms, depression, lack of appetite, and debilitating loss of coordination. 

Currently, there is no known cure for ALS and there are few treatment options, but some doctors suggest cannabis can help. ALS patients can benefit from the complex interaction between multiple cannabinoids, including THC, CBD, CBN, THCv, and CBC. Most of the evidence that exists in support of cannabis for ALS is anecdotal, but in 2001 a group of researchers published a review in the American Journal of Hospice and Palliative Care saying a "variety of symptoms caused by ALS can be alleviated via the use of medical marijuana, including pain, spasticity, wasting, drooling, and depression." Other researchers found that THC actually prevented the condition from progressing. 

As with most conditions, there is a substantial need for clinical trials that will help us better understand medical marijuana's ability to treat ALS. For more information on what is already known for medical marijuana and ALS, read this feature written by Whaxy:

Weed for Weight Control?

Using weed to control weight gain seems ironic. Marijuana has long been associated with the "munchies," or the desire to eat any junk food in sight. This stereotype is not without substance. Studies have shown marijuana to stimulate appetite in animals and humans alike, and many states have approved the use of marijuana in those suffering from uncontrollable weight loss, the anorexia associated with chemo and debilitating diseases, as well as cachexia or wasting syndrome. 

Now, however, some studies are showing marijuana can be effective in reducing obesity. Researchers found that among several different groups of human populations, obesity was less prevalent among cannabis consumers. The authors concluded, "even if cannabis consumption increases appetite, people using cannabis are less likely to be obese than people who do not use cannabis." The credit for combating obesity goes to the cannabinoid THCV, which was found to reduce weight and appetite and modulate feeding behaviors. Reducing obesity is important because there are many health problems associated with it, such as heart disease and stroke, diabetes, osteoarthritis, and certain types of cancers. The rate of obesity is increasing in populations worldwide, so it is now more important than ever to discover and research new ways for combating the problem.

THCv: Tetrahydrocannabivarin Cannabinoid Profile

When it comes to knowing your cannabinoids, everyone knows the more infamous cannabinoids like THC, CBD, and CBG. In reality, there are so many more. The cannabis plant has more than 111 cannabinoids, so why should we limit our knowledge to just a select few? With the help of Whaxy's cannabinoid profiles, we have a few more insights into the lesser known cannabinoids. Tetrahydrocannabivarin (THCv) may resemble the more commonly known cannabinoid THC in structure, but it's medical efficacy is vastly different. While there isn't much research behind THCv, some think that it could potentially treat a variety of conditions, including PTSD, epilepsy, and obesity. Reasons researchers speculate this is that THCv has psychoactive properties that produce a sense of euphoria, anti-convulsive properties to reduce seizures in epilepsy patients, and appetite suppressant properties that could combat obesity. THCv could have the ability to help many, but it may be difficult to find strains that contain the cannabinoid, as the strains containing it are relatively rare. To read more about Tetrahydrocannabivarin, visit this link: