CBD and Parkinson's Disease

Photo Credit: Flickr (https://bit.ly/2W1mdDU).

Photo Credit: Flickr (https://bit.ly/2W1mdDU).

Research suggests the non-psychoactive cannabinoid cannabidiol (CBD) may have the ability to treat symptoms associated with Parkinson’s disease because of its neuroprotective and antipsychotic effects. It may also be able to help improve symptoms that interfere with sleep. One study from 2005 found CBD had neuroprotective benefits in animal models of Parkinson’s. The study believed these effects may be the result of CBD’s antioxidant and anti-inflammatory properties. Through the studies, researchers suggested CBD could protect brains from progressive dopamine neuron loss. In 2007, the same researchers found CBD was most effective at protecting neurons if administered immediately after exposure to toxins.

Other studies have found CBD can improve movement impairments, psychosis, sleep disturbances, and quality of life for those with Parkinson’s disease. A study from 2017 found CBD improved movement impairments through blocking the receptor known as GPR6, which allows dopamine levels to increase. A 2009 trial published in the Journal of Psychopharmacology found six patients with Parkinson’s who were given 150 mg/day of CBD for four weeks exhibited remarkable improvements in their psychotic symptoms. The cannabinoid was also safe and well-tolerated. Another trial from 2014 which involved 21 patients found CBD improved quality of life, likely due to the cannabinoid’s antidepressant, anxiolytic, antipsychotic, and sedative effects. A series of case studies found daily doses of 75-300 mg CBD could reduce or eliminate REM sleep behavior disorder in patients.

THC may also help patients with Parkinson’s disease, and one study from 2014 found it improved movement dysfunction and overall movement deficiencies like tremor, rigidity, and slowed movements. It also helped with sleep disturbances and pain. THC on its own is a psychoactive cannabinoid, and can produce paranoia, anxiety, panic attacks, and increase heart rate which could lead to heart attack. So, the cannabinoid alone may not be the preferred cannabinoid for many patients. That said, using a combination of THC and CBD may be appropriate for those users who want the ultimate relief, as CBD buffers against the effects of THC and the two together can provide benefits and can target a wider range of symptoms.

This information has been provided by Leaf Science and approved by our Chief Medical Officer.

What Are CBD Topicals?

Photo Credit: PixaBay

Photo Credit: PixaBay

For patients who want localized relief, CBD topicals may be the most desirable option. CBD topicals include creams, lotions, salves, balms, and oils that are infused with CBD and can be applied to specific areas for targeted symptom relief. Through this vehicle, CBD is absorbed through the skin before interacting with the endocannabinoid system. In rodent models, CBD preparations successfully absorbed through the skin’s tissues and provided effective pain and inflammation relief in a dose-dependent manner. CBD topicals are suggested for pain and inflammation relief, so may be effective for conditions like psoriasis and arthritis. CBD can also be beneficial for skin’s overall health, and its powers as an antioxidant can keep the skin young healthy.

You can determine if topicals may be the most desirable vehicle for you with our app! Through the journaling function, you can monitor and titrate the different aspects of your dosing regimen to figure out what routine provides the best relief. Journaling daily will improve your results.

This information has been provided by Leaf Science and approved by our Chief Medical Officer. This post does not represent an endorsement on behalf of Leaf Science for CannaBest Medical products.

What is Hemp CBD?

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Photo Credit: Full Spectrum University / https://bit.ly/2Edi84e

Hemp CBD is cannabidiol that is derived from the hemp plant as opposed to from the marijuana plant. CBD is a desired cannabinoid due to its ability to benefit a myriad of conditions while not producing any psychoactive side effects. Some parts of the hemp plant are federally legal, making it more widely accessible to patients than CBD derived from marijuana. There is more CBD present in marijuana due to its large amount of resin, so it is easier to extract CBD from marijuana and requires fewer plants. CBD, whether it comes from marijuana or from hemp, is the same molecule, but where it differs is the plant itself. Because of this, CBD taken from marijuana may contain other beneficial cannabinoids and terpenes that may not be present in hemp extractions.

This information has been provided by Leaf Science and approved by our Chief Medical Officer.

The Differences Between THC and CBD

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

Of the more than 100 cannabinoids found in marijuana, the cannabinoids most commonly associated with the plant are Tetrahydrocannabinol (THC) and Cannabidiol (CBD). These cannabinoids interact with the Endocannabinoid System (ECS), a system which is known to regulate pain, appetite, mood, memory, immune response, sleep, and cellular level life cycles. THC will bind directly to CB1 and CB2 receptors in the ECS, with a higher affinity for CB1 receptors, while CBD acts as an indirect antagonist of cannabinoid receptor agonists, and even binds with non-cannabinoid receptors.

Many medical marijuana patients opt for CBD in their routines due to the fact it does not produce psychoactive or euphoric effects like THC. In fact, for those who desire the therapeutic relief that THC offers, CBD can actually buffer against its psychoactive effects, so that the patient can experience symptom relief without unwanted side effects. THC may produce side effects like memory impairment, lowered reaction time, increased heart rate, coordination problems, dry mouth, and red eye. One can’t overdose from THC, but adolescence who consume high amounts of THC may experience long-term psychiatric side effects. CBD, on the other hand, is considered all around well-tolerated and safe, and the only potential mild side effects include dry mouth, light-headedness, and drowsiness. Producers can produce medical marijuana strains with different cannabinoid compositions tailored to the specific needs of patients. That said, many marijuana strains, especially in today’s world of high potency marijuana, contain higher amounts of THC while hemp contains very little THC and strong concentrations of CBD.

This information has been brought to you by Medical Marijuana Inc. and approved by our Chief Medical Officer.

CBD And Its Effects On The Human Body

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

Cannabidiol (CBD) is one of the more prominent and well known cannabinoids in cannabis. Many patients find CBD preferable for its ability to enhance health and wellness without producing the psychoactive high associated with THC and cannabis. To produce therapeutic benefits, CBD interacts with the body’s endocannabinoid system, which is responsible for regulating mood, memory, appetite, pain, immune response, and temperature. Many scientists believe that CBD works best synergistically alongside other cannabinoids and terpenes, even in trace amounts, in what is known as the entourage effect. The amount of time it takes for CBD to begin to take effect is fully dependent on the dose, the vehicle of administration, and other factors that influence the rate of absorption. This can range from minutes to hours. When CBD is ingested, it must be digested before taking effect. Sublingual absorption, however, allows the cannabinoid to bypass digestion and take effect faster. Vaping CBD oil takes effect almost immediately because it is absorbed through the lungs’ alveoli. Topical applications allow for targeted and localized relief that does not rely on entering the blood stream.

This information has been brought to you by Medical Marijuana Inc. and approved by our Chief Medical Officer.

Is It Safe To Take CBD Oil?w

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

Cannabidiol (CBD) is a non-psychoactive cannabinoid praised for its ability to treat a myriad of symptoms while being well tolerated and producing few side effects. The cannabinoid is recognized for its high safety profile, but what exactly does that mean?

CBD is recognized as safe because it is non-toxic for humans and animals, even when administered in high doses, making it next to impossible to overdose on the cannabinoid. One study from the Department of Clinical, Toxicological and Food Sciences Analysis at the University of São Paulo, Brazil, found even doses as high as 1,500 mg/day of CBD were well tolerated. Unlike the cannabinoid THC, CBD is non-psychoactive, making it applicable in treatment regimens where patients desire relief without feeling “high.” CBD also produces few side effects that are generally considered to be mild. Some of these include dry mouth, low blood pressure, wakefulness (except when taken in high doses, in which drowsiness can occur), and inhibition of hepatic drug metabolism, which means it can interfere with the metabolization of certain pharmaceutical medications.

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer.

10 Facts About Cannabidiol (CBD)

Photo Credit: Leaf Science

Photo Credit: Leaf Science

Cannabidiol is one of the better understood cannabinoids of the over 113 known cannabinoids that exist in cannabis. It’s gaining in popularity for its ability to treat a wide range of conditions without producing psychoactive side effects, but how well do you know the cannabinoid? Let’s look at the facts!

Because CBD does not act on the same receptors as THC, it is able to provide a myriad of health benefits without producing the psychoactive high that marijuana is known for. This makes the cannabinoid appropriate for use in pediatric treatment and makes it desirable among health professionals and patients who want symptom relief without any side effects. According to the British Journal of Clinical Pharmacology, CBD is able to act as an antiemetic, anticonvulsant, antipsychotic, anti-inflammatory, anti-oxidant, anti-tumoral and anti-cancer, anxiolytic and antidepressant, and an analgesic.

Although CBD can provide all of these benefits, one of the strengths of cannabinoid is that it is able work alongside other cannabinoids and terpenes to provide maximum relief through what is known as the “entourage effect.” Through this, CBD can actually buffer against the negative side effects of THC, so that patients can experience the therapeutic benefits of that cannabinoid with less severe side effects. CBD’s safety profile is so high that people have even started using it to treat ailments in their pets. Depending on dosage, CBD can either increase wakefulness among users, or provide sedative effects that facilitate sleeping. Larger doses help people stay asleep longer, while small doses help stimulate energy and help people wake up.

This information has been provided by Leaf Science and approved by our Chief Medical Officer.

Neurologist Dr. Carlos Aguirre's Survey Demonstrates CBD's Powerful Effects on Seizures

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Photo Credit: Medical Marijuana Inc.

Pediatric neurologist Dr. Carlos G. Aguirre-Velazquez has released continuing results from his clinical study involving the use of CBD oil for seizures relating to tuberous sclerosis complex (TSC). Dr. Aguirre measured the frequency, intensity, and duration of convulsive crises in TSC patient, as well as studied their quality of life, use of prescription drugs, and the long-term sustainability of CBD treatment. The results of his study are positive, with 60% of participants exhibiting clinically significant (60-80%) reductions in the frequency of their seizures with the use of CBD products. Additionally, patients using CBD experienced an improvement in mood, appetite, cognition, and overall quality of life, without experiencing adverse side effects, suggesting CBD can be used consistently while maintaining a high safety profile. Minor side effects like drowsiness and appetite increase existed, but they could improve or dissipate with adjusted doses. Researchers explained, “The experience of parents and patients with medicinal cannabis (CBD), as reported in our survey, suggests that CBD reduced the frequency, intensity, and duration of convulsive crises secondary to TSC.”

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer.

Treating Autism With Cannabis Now Has Scientific Support

Photo Credit: Civilized

Photo Credit: Civilized

A new study has found CBD extract may be able to provide support for those diagnosed with autism. Many researchers attribute the symptoms of Autism Spectrum Disorder (ASD), which include problems in communication, odd social interactions, restricted or repetitive movements, to reduced inhibition in the brain. Now, in a breakthrough study, a team of researchers from the University of Washington has sought to use CBD as a way of restoring inhibition in the brain. Scientists used a genetic mouse model, in which the genes have been mutated in order to produce the symptoms of Dravet Syndrome, which includes inducing spontaneous seizures and exhibiting autism-like behaviors, to determine the effects of CBD on autism, specifically. In the model, mice were offered a choice between interacting with other mice or objects. While mice would usually prefer to spend time with other mice, the autistic-like mice usually have no preference and will split their time equally between the two. Upon receiving small amounts of CBD (about 10-20% of the anti-epileptic dose), the autistic-like mice significantly increased the amount of time they spent with other mice. Additionally, CBD reduced the urge autistic-like mice felt in escaping these social situations, and they exhibited improved performance in regards to the quality of their social interactions.

To understand these results, the researchers recorded electrical signals within the brains of the individual mice. They found CBD blocked the brain receptor GPR55 from interfering with how the brain cells communicated, thereby restoring balance and brain inhibition. The next steps will involve breaking down the barriers that exist as a result of cannabis’ Schedule I status so that researchers can test the effects of CBD on autism in large-scale human models. This information has been provided by Civilized and approved by our Chief Medical Officer.

CBD Hemp Oil Beneficial for HPV Vaccine Side Effects, Study Suggests

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

A new study published in the Israel Medical Association Journal suggests CBD hemp oil could help reduce the symptoms and improved the quality of life for patients who suffer from adverse side effects like severe somatoform and dysautonomic sydrome after receiving HPV vaccination. Researchers entered the study with the notion that adverse side effects resulting from HPV vaccinations may be related to an imbalance in the endocannabinoid system. Authors of the study, who hailed from the University of Modena and the Reggio Emilia Medical School, wrote, “Due to the absence of a safe and effective therapy for these girls who were living with their families and having to deal with difficult conditions (such as emotional instability, social problems as well as school obligations), and suspecting that an endogenous cannabinoid network imbalance might be responsible for some of the described symptoms, we selected a natural therapeutic approach based on CBD-enriched hemp oil over a 3 month period in our Italian cohort.”

In the open-label study, 12 female patients between the ages 12 and 24 that had an adverse response to HPV vaccinations received sublingual CBD hemp oil drops over the course of three months. Each patient received 25 mg/kg daily, alongside 2-5 mg/ml CBD once a week, until they received the maximum dose of 150 mg/ml CBD per day. Researchers observed the oil presented, “significant benefits in the physical component score, vitality and social role functioning… This study demonstrated the safety and tolerability of CBD-rich hemp oil and the primary efficacy endpoint.” Two patients withdrew from the study claiming they experienced no benefits. While the results are hopeful, the researchers urge for blind clinical research to substantiate these results.

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer.

CBD Improves Quality of Life Measures in Parkinson's Disease Patients, Trial Finds

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Photo Credit: Medical Marijuana Inc.

A new study published in the Journal of Psychopharmacology has determined patients suffering from Parkinson’s disease may be able to improve their quality of life and overall well-being with the use of CBD. The double-blind clinical trial, which was conducted by researchers at Brazil’s University of São Paulo, involved 21 patients suffering from Parkinson’s disease without demential or comorbid psychiatric conditions. The patients were separated into three groups, and then given either placebo, 75mg CBD, or 300 mg CBD over the course of six weeks. At five weeks in, researchers tested for motor and general symptoms, well-being and quality of life, and neuroprotective effects. To measure well-being and quality of life, researchers provided patients with the Parkinson’s Disease Questionnaire, which considers mobility, activities of daily living, emotional well-being, stigma, social support, cognition, communication, and bodily discomfort.

Those receiving the more potent dose displayed significant improvements in quality of life and well-being. There were no major differences in motor symptoms and neuroprotective effects between the different groups after 6 weeks, but researcher explained this may be attributed to the small sample size, the short duration of the study, or the fact that many patients were in the early stages of the disease and so had low baseline scores. The study concludes, “Nowadays, most drugs used in the treatment of [Parkinson’s disease] act in the dopaminergic system and little is known about the role of other neurotransmitter systems in the disease… The endocannabinoid system seems to be an important target of investigation, mostly because of its action in those considered as the non-motor symptoms of [Parkinson’s disease and of reports of its possible neuroprotective effects.”

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. You can also access the study here.

42% Of New CBD Users Stop Taking Traditional Medicines

Photo Credit: Civilized

Photo Credit: Civilized

A survey conducted by Brightfield Group and HelloMD has found 42% of CBD users were able to stop the use of traditional medications, ranging from common Tylenol pain relievers to prescription medications like Vicodin. Other findings included 80% of CBD users found the cannabinoid to be extremely effective, less than 3% found it to be ineffectual or slightly ineffective, and 55% or users were female. The study involved 2400 of HellMD’s members.

This information has been provided by Civilized and approved by our Chief Medical Officer.

How Cannabidiol (CBD) Works for Treating Anxiety

Photo Credit: Leafly

Photo Credit: Leafly

Various animal studies and human experimental, clinical, and epidemiological studies suggest CBD has powerful anti-anxiety properties, and when administered acutely, it seems both safe and well-tolerated. This suggests the cannabinoid could be helpful for the treatment of panic disorder, obsessive compulsive disorder (OCD), social phobia, post-traumatic stress disorder (PTSD), generalized anxiety disorder (GAD), and mild to moderate depression. Many pharmaceutical medications known as SSRIs work to target serotonin receptors to reduce anxiety and depression. Like SSRIs, CBD may be able to support signaling through serotonin receptors, and in one animal study, Spanish researchers found CBD enhanced 5-HT1A (a subtype of serotonin receptor) transmission ad affected serotonin faster than SSRIs.

Brain scans of those who suffer from depression or anxiety often show a smaller hippocampus, which is an area of the brain known for its role in memory formation and cognition. Treatments of depression are often associated with neurogenesis within the hippocampus. One animal study found consistent administration of CBD promoted neurogenesis in the hippocampus, suggesting it may help treat anxiety and depression. in a small double-blind study, Brazilian researchers found patients afflicted with generalized social anxiety reported significant decreases in anxiety after CBD consumption. These claims were validated through the support of brain scans that showed cerebral blood flow patters consistent with anti-anxiety effects. Another small study found patients with social anxiety disorders reported less anxiety while performing public speaking tests after the use of CBD. These findings were supported by indicators relating to heart rate and blood pressure.

This information has been provided by Leafly and approved by our Chief Medical Officer.

New Research Review Confirms Favorable Safety Profile of CBD

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

A new research review published in Cannabis and Cannabinoid Research support the notion that cannabidiol (CBD) is safe for human consumption. Investigators Iffland Kerstin and Grotenhermen Franjo from German research center nova-insisut built upon Mateus Machado Bergamaschi's comprehensive survey that analyzed various studies involving controlled CBD for humans and animals. This new review updated the existing information with new findings from both preclinical and clinical trials. Researchers concluded that the studies indicated CBD had no adverse psychological effect on blood pressure, heart rate, body temperature, glucose levels, pH, pressure exerted by carbon dioxide or oxygen, hematocrit, gastrointestinal transit, emesis, rectal pressure, or potassium and sodium levels. One study found 60 mg/kg of CBD given to mice three days weekly for twelve weeks had no adverse effects on any of their bodily movements. Chronic use of CBD in humans has proven to have no neurological, psychiatric, or clinical adverse effects, nor any respiratory depression or cardiovascular complications. 

The new review also indicates CBD may possess immunomodulatory and neuroprotective properties, and may have the ability to support the treatment of heroin addiction, reduce seizures, manage psychosis, inhibit cancer, and reduce anxiety. There may be some drug interaction between CBD and pharmaceutical medications, including any medications metabolized by enzymes from the cytochrome P450 family, which include: Lipitor (atorvastatin), Xanax (alprazolam), caffeine, naproxen, ibuprofen, acetaminophen, and codeine. CBD may also inhibit the enzymes CYP2D6 and CYP2C9, which could reduce how medications like omeprazole, risperidone, warfarin, and diclofenac are metabolized. Additionally, in vitro studies have noted CBD inhibits the ABC transporters P glycoprotein and Breast Cancer Resistance Protein, which could interfere with some anticancer drugs binding to transporters. On the other hand, certain drug interactions have been beneficial, and one 8-week-long clinical study on children with epilepsy found CBD increased the bioavailability of the anti-epileptic medication clobazam, so patients could more effectively manage their seizures while reducing their dose of the anti-epileptic medication.

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

More Evidence Indicates CBD is Beneficial for Alzheimer's Disease

Photo Credit: Nick Youngson / Alpha Stock Images  Nick Youngson  /  Alpha Stock Images

Photo Credit: Nick Youngson / Alpha Stock Images Nick Youngson / Alpha Stock Images

According to a new research review published in Frontiers in Pharmacology, CBD produces various therapeutic benefits against Alzheimer's disease. Australian researchers were prompted to review articles that had previously investigated CBD's effects on the disease because they were intrigued by the compound's neuroprotective, anti-inflammatory, and antioxidant properties, all of which could reduce or inhibit the cognitive and functional impairment resulting from Alzheimer's. Some of the in vivo studies reviewed suggested CBD reduced reactive gliosis and the neuroinflammatory response, something that has been linked to neurodegeneration in Alzheimer's. CBD may also promote neurogenesis to reduce deterioration of cognitive functions. Preclinical animal studies suggested CBD reverses and prevents cognitive deficits from developing. Other studies found CBD's effects are further enhanced by THC, and that a combination offers greater anti-dementia effects without producing the psychoactive effects that THC alone would produce.

The review concludes, “The studies reviewed in this mini review provide “proof of principle” for the therapeutic benefits CBD and possibly CBD-THC combinations pose for AD therapy... The studies discussed here provide promising preliminary data and the translation of this preclinical work into the clinical setting could be realized relatively quickly: CBD is readily available, appears to only have limited side effects and is safe for human use.”

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. You can also read the full text of the study here.

New Study: CBD May Help Treat Schizophrenia

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

In a recent animal study published in Neuropsychopharmacology, researchers from the Illawarra Health and Medical Research Institute determined cannabidiol (CBD) could help treat the negative and drug resistant symptoms of schizophrenia. The team set out to investigate whether or not the non-psychoactive CBD could improve the cognitive impairments and concentration and memory difficulties that often coincide with schizophrenia, and found CBD improved recognition and working memory, and social behavior. To conduct the study, the team used a prenatal infection model to examine the effects of consistent CBD treatments on cognition and social interaction. On the 15th day of gestation, the pregnant rats were infected with polyinosinic-polycytidylic acid to produce psychiatric disorders. The male rat offspring were then given 10 mg/kg CBD for three weeks, and were then tested for cognition and working memory and sociability. The team also looked at body weight and food and water intake. 

The medications that are currently used for schizophrenia are generally effective at reducing delusions and hallucinations, but they are not particularly good at treating the cognitive and negative emotional and social symptoms, and they can produce negative side effects. Study author Ashleigh Osborne explains, “These findings are interesting because they suggest that CBD may be able to treat some of the symptoms of schizophrenia that are seemingly resistant to existing medications. In addition, CBD treatments did not alter body weight or food intake, which are common side effects of antipsychotic drug treatment.” The team was inspired to undertake this study after sifting through 27 previous studies, where supervisor Dr. Katrina Green says they discovered “CBD will not improve learning and memory in healthy brains, but may improve aspects of learning and memory in illnesses associated with cognitive impairment, including Alzheimer’s disease, as well as neurological and neuro-inflammatory disorders. Evidence suggests that CBD is neuroprotective and can reduce cognitive impairment associated with use of delta-9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis.”

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

CBD Could Help Treat Schizophrenia Symptoms, Study Finds

Photo Credit: Civilized

Photo Credit: Civilized

Researchers from the Illawarra Health and Medical Research Institute (IHMRI) have recently determined CBD isolate could treat the negative cognitive symptoms that coincide with schizophrenia, including social withdrawal and blunted emotional expression. The study, which was published in the journal Neuropsychopharmacology, involved using a rodent model of schizophrenia and comparing rats treated with CBD to those left untreated. The researchers found CBD restored cognition, working memory, and social behavior.

This information is significant considering past research has suggested cannabis actually heightened the risk of developing psychoses. University of Wollongong PhD candidate Ashleigh Osborne notes CBD may fill a void left by current antipsychotic medication treatments, explaining, "This is really important because current antipsychotic drugs don't address the cognitive deficits, which approximately 80 per cent of patients with schizophrenia experience... This is the first study to prove Cannabidiol can be used to treat symptoms of schizophrenia that aren't addressed by current medications."

Further research is desired to see if the results produced by he rodent model would translate to actual people suffering from schizophrenia. This information has been provided by Civilized and approved by our Chief Medical Officer.

Study Reveals CBD Reduces Kids’ Seizures by 50 Percent

Photo Credit: MassRoots

Photo Credit: MassRoots

A new study conducted by the American Academy of Neurology found CBD decreased atonic seizures (commonly known as "drop" seizures) by as much as 50% in patients suffering from a specific and severe form of epilepsy known as Lennox-Gastaut Syndrome (LGS). The study involved 225 participants with LGS who experienced an average of 85 atonic seizures per month and who had tried an average of six epilepsy medications without finding relief. During the study, each patient also took an average of three epilepsy medications. The patients were divided into three groups, in which one group was given 20 mg per kg of body weight, while another received 10 mg/kg, and the last group received placebo. 

Of the first group, 42% saw a reduction in atonic seizures, with 40% of them saying their seizures were cut in half. Of the second group, 37% experienced a reduction, with 36% of them saying their seizures were cut in half. The placebo group experienced a 17% reduction in atonic seizures, with 15% saying their seizures were cut in half. While side effects were reported, they were mild and consisted of drowsiness and a limited appetite. All in all, those who took CBD treatment were 2.6 times more likely to report an improvement in their conditions.

Author of the study Anup Patel, MD, of Nationwide Children's Hospital and the Ohio State University College of Medicine, explains, “Our results suggest that cannabidiol may be effective for those with Lennox-Gastaut syndrome in treating drop seizures... This is important because this kind of epilepsy is incredibly difficult to treat. While there were more side effects for those taking cannabidiol, they were mostly well-tolerated. I believe that it may become an important new treatment option for these patients.”

This information has been provided by MassRoots and approved by our Chief Medical Officer. 

Study Aims to Find Out if CBD can Shrink Children's Tumors

Photo Credit: High Times

Photo Credit: High Times

Scientists from the Nottingham University's Children's Brain Tumor Research Centre aim o find out whether or not CBD could be beneficial in treating brain tumors in children. The studies that already exist are all preclinical trials, but they have found CBD reduces mitochondrial oxidative metabolism to reduce the viability of cells that make up tumors and inhibit their progression in animal and culture models. The study underway involves administering CBD to to laboratory grown cells made from ependymoma and glioma tumors over the course of seven days. Then, the spreading behavior of the treated and untreated cells will be compared using cell staining. The professor leading the study, Professor Richard Grundy, says, “We expect the cells – brain tumor and normal brain – grown in our standard conditions to be healthy and actively dividing. We expect that normal brain cells grown in cannabidiol will remain healthy. However, we expect the brain tumor cells grown in cannabidiol to stop growing and die.”

With the rates of cancer diagnosed in children has slightly increased in recent decades, finding more effective treatment methods that are not as toxic as chemotherapy and radiotherapy is desired. Grundy explains, “New ways to treat childhood brain tumors are urgently needed to extend and improve the quality of life in malignant brain tumor patients, so we are excited at the prospect of testing the effect of cannabidiol on brain tumor cells.”

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

MMJ Breakthrough Might Be Miracle Treatment for Autism

Photo Credit: High Times Magazine

Photo Credit: High Times Magazine

There's an exciting study underway in Israel testing the effects of medical marijuana on autism. Nearly half of the participants of the study had responded negatively to anti-psychotic medications. There has been substantial anecdotal data to support the use of cannabidiol (CBD) for autism, and this clinical study led by Dr. Adi Aran intends to determine if there is in fact a link between CBD and autism symptoms. There are 120 children and young adults between the ages of 5 and 29 who are participating in the study, all of which have a form of autism ranging between mild and severe. Participants receive drops of either a placebo, or one of two different CBD variations, which they mix into food. The study is on track to conclude this year. 

Stay tuned to see what is to come of this study. This information has been provided by High Times Magazine and approved by our Chief Medical Officer.