Is More CBD Better? The Science Behind CBD Dosing for Anxiety and Other Conditions

Photo Credit: Leafly

Photo Credit: Leafly

Cannabidiol (CBD) is famed for its ability to fight epilepsy and buffer against the side effects of THC, among other things. So the question begs to be asked - is more CBD necessarily better? In short, no, and like most medications, the efficacy medical marijuana is dependent on a variety of factors including its dosage. This is known as the “inverted-U” effect, and it’s not uncommon among medications that, like CBD, affect multiple brain receptors. Of published toxicology articles, 37% report a degree of inverted-U responses, which reflects differential drug effects on the brain. CBD is applicable for a wide spectrum of treatments, including pain, anxiety, PTSD, and more, suggesting it has a plethora of brain and body targets.

At low doses, CBD can prevent endocannabinoids and phytocannabinoids from binding with receptors in the nervous system, which may be why it is effective at blocking some of the side effects produced by THC. Additionally, low to moderate doses of CBD are more effective at treating anxiety, as was suggested in one animal study from 1990 where CBD became less effective as an anti-anxiety medication as the dosage increased. These results were supported by human trials, in which low to moderate doses of CBD eased the stresses of social anxiety disorder and public speaking. CBD treats anxiety at about 25% of the amount required to treat epilepsy, showing CBD is effective at much higher doses for this condition.

This is why titrating CBD is essential in determining the perfect amount to experience symptom relief, and our app can help. Journaling daily on our app allows you to keep track of how you’re dosing so you can understand which aspects of your regimen are working, and which aspects of your regimen are not. This information has been provided in part by Leafly and approved by our Chief Medical Officer. This post does not represent an endorsement on behalf of Leafly for CannaBest Medical.

Study Finds Epilepsy Patients Feel Better After Daily CBD Regimen

Photo Credit: Leafly

Photo Credit: Leafly

According to a new study funded by the state of Alabama, patients in Alabama with intractable epilepsy felt better overall within one year of beginning CBD therapy even in the face of declining social support and stressful events. Although lead researcher Barbara Hansen did admit she cannot definitively point to CBD as the agent producing relief, she did confirm each patient in the study was administered CBD. In this open-label study, researchers from the University of Alabama at Birmingham distributed 100 mg/ml CBD solutions to patients. The study involved a range of participants aged 1-63 years old, and it took place for just over two years between the years of 2015 and 2017.

Participants initially started with doses of 5mg of this solution for every kg of their weight on a daily basis, divided into two spoonfuls. Every two weeks they had the opportunity to increase their dose by 5 mg, with a maximum at 50 mg/kg a day. They then were asked to complete the Interpersonal Support Evaluation List, and a measure from a 0-1 scale perception of their overall health. One year later, 77.4% of participants reported good feelings, compared to 73.3% at the beginning. Overall, patients reported .2-3 points of decline in their ISEL scores despite reporting an average of .29 increase in stressful events. Children witnessed a decrease in stressful events by .86. Some patients withdrew from the study before their followup surveys, and although the study began with 135, the data collected came from only 62 patients who continued in the study. This study will continue.

This information has been provided by Leafly and approved by our Chief Medical Officer.

Study Determines CBD is Effective as Adjunctive Therapy for Psychosis

Photo Credit: The Daily Chronic

Photo Credit: The Daily Chronic

Clinical trial data published in The American Journal of Psychiatry suggests patients who suffer from schizophrenia could manage their psychotic symptoms better through the addition of CBD therapy on a daily basis. In the randomized trial, British researchers compared the addition of 1000 mg of CBD to the addition of placebo in 88 patients’ conventional therapy regimens over the course of six weeks. At the end of the trial, researchers say those who received CBD “had lower levels of positive psychotic symptoms and were more likely to have been rated as improved and as not severely unwell by the treating clinician.” CBD also improved cognitive performance and overall functioning in patients, but these results were not significant statistically. Authors conclude, “These findings suggest that CBD has beneficial effects in patients with schizophrenia… As CBD’s effects do not appear to depend on dopamine receptor antagonism, this agent may represent a new class of treatment for the disorder.”

This information has been provided by the Daily Chronic and approved by our Chief Medical Officer.

What Are The Medical Benefits of CBD? - Part 3

Photo Credit: NeedPix (https://bit.ly/2XK0i4H)

Photo Credit: NeedPix (https://bit.ly/2XK0i4H)

Let’s continue our discussion of which conditions could benefit from CBD treatment by beginning with strokes. One animal study found CBD reduced two types of brain damage caused by a stroke, so much so that the outcomes of the group which had the stroke were comparable to the control group that did not. Its neuroprotective properties may help prevent brain damage and help patients heal. When administered before trauma, CBD can also protect against the damage caused by spinal cord injury, and aid in the healing process. Because of its neuroprotective effects, CBD may also be beneficial for those with traumatic brain injury, and studies suggest the cannabinoid protects neurons following injury, reduces the formation of scar tissue, and regenerates neuronal axons. CBD may also treat nicotine addiction, and in one study involving 24 smokers, some smokers received a placebo inhaler while some received a placebo inhaler. Smokers were instructed to use the inhaler when cigarette cravings struck. Those who received the placebo did no reduce their cigarette usage, while those who received CBD reduced their use by 40%.

The medication Sativex, which contains equal parts CBD and THC, has been found to effectively lower scores of spasticity related symptoms in patients with moderate to severe Multiple Sclerosis, even when these patients were previously treatment-resistant. CBD also reduced the production of cytokines, and activated an important biological pathway blocked by multiple sclerosis. Sativex may also help those with ADHD. CBD was also found to improve social interaction and reduce hyperactivity in rats with ADHD. CBD may also promote wakefulness in those who suffer from sleep disorders that cause excessive sleep. CBD also improved the quality of sleep in young patients who suffered from PTSD. CBD may also help patients heal from liver disease. One study found CBD reduces the neurological damage and cognitive impairments caused by toxins that remain in the blood as a result of liver failure. CBD also restored liver and brain function. Lastly, when taken before and after surgery, CBD increased the success rates of bone marrow transplants, and patients who received CBD were less likely to develop graft versus host disease.

This concludes our series examining the many uses for CBD. This information has been provided by Leaf Science and approved by our Chief Medical Officer.

What Are The Medical Benefits of CBD? - Part 2

Photo Credit: NeedPix (https://bit.ly/2XK0i4H)

Photo Credit: NeedPix (https://bit.ly/2XK0i4H)

In today’s post, we’ll continue our discussion of which conditions could benefit from CBD treatment.

We’ll begin with Alzheimer’s disease, which scientists believe CBD could treat or even prevent its onset. A 2013 study found CBD prevented the development of amyloid beta plaques, while another study found CBD promoted the growth of new brain cells that were lost to damage caused by the condition, and that it improved symptoms associated with cognitive deficits. The topical application of CBD may treat acne, and studies have found it can reduce inflammation and the production of sebum oil, as well as halt the development of acne. CBD can also help with psoriasis, and studies have found the cannabinoid can prevent the spread of cells that cause the condition’s patches. CBD may also help cancer patients, not only by reducing the nausea and vomiting associated with chemotherapy, but also by preventing the spread of cancer cells and causing cancer cell death. Studies have also found CBD slows the formation of blood vessels within tumors, thereby blocking nutrients from entering the tumor and slowing its growth.

CBD has also been earning a name lately for treating pain and reducing the need for the harmful opiate medications that are traditionally used. Studies have found CBD reduces inflammation and the sensory perception and emotional effects of pain. Research suggests CBD is more effective at treating long-term neuropathic pain than short-term pain. CBD may protect against heart disease, and studies have found the cannabinoid protects cardiac cells when blood supply to the heart is blocked, stops heart arrhythmia, and reduces cardiac damage when oxygen is block. CBD also reduces heart disease from diabetes by reducing inflammation, oxidative stress, scarring, and cell death. The topical application of CBD can target localized areas of pain caused by arthritis. Studies have found CBD blocks pain and prevents nerve damage from osteoarthritis, as well as uses anti-inflammatory and immunosuppressive effects to blog the condition’s progression. Some studies have found CBD may be able to stabilize mood, something that could be helpful for those suffering from Bipolar Disorder. That said, CBD was only effective during depressive stages, and not during manic phases.

That’s not all! Stay tuned for tomorrow’s post to learn more about which conditions CBD could help. This information has been provided by Leaf Science and approved by our Chief Medical Officer.

What Are The Medical Benefits of CBD? - Part 1

Photo Credit: NeedPix (https://bit.ly/2XK0i4H)

Photo Credit: NeedPix (https://bit.ly/2XK0i4H)

As legalization proceeds and barriers to medical marijuana research are knocked down, we are becoming more aware of just how powerful wide-reaching medical marijuana is. One of the cannabinoids getting the most attention is cannabidiol (CBD), a non-psychoactive cannabinoid that can help a myriad of conditions. In this series, we will discuss some of the many conditions CBD can treat.

Numerous studies have suggested CBD can reduce anxious feelings in those with anxiety disorders, and that it can effectively treated a variety of anxiety disorders, including OCD, panic disorder, generalized anxiety disorder, PTSD, and social anxiety disorder. Studies also suggest CBD could benefit those who suffer from depression. Animal studies have shown CBD acts on the serotonin pathways in the brain, allowing it to act as an antidepressant, and one study found CBD reduces anhedonia, which is a symptom of depression that prevents people from feeling joy or happiness. CBD can also stop nausea and vomiting. One study found CBD effectively helped treat nausea in patients who did not get relief from traditional treatments. CBD may also help those with diabetes, and animal studies have found the cannabinoid slows the progression of diabetes and diabetic inflammations, as well as benefit complications associated with diabetes. CBD may also protect against diabetes, and one study found CBD prevented at-risk mice from developing the condition.

Perhaps the most well-known success story for CBD is its ability to treat epilepsy. CBD has acted as an anticonvulsant in animal models, and GW Pharmaceuticals have been testing their CBD oil Epidiolex with success. In the study, 25 and 50 mg/kg a day lowered seizure frequency by half while producing few mild side effects. Additionally, a 2013 survey of parents of children with treatment-resistant epilepsy found 84% reported reduced seizure frequency with CBD use. Lastly, and contrary to previous beliefs, CBD may treat schizophrenia and mental illnesses related to psychosis. It has been found to be as effective as antipsychotics with fewer side effects, and scientists believe this could be attributed to the stimulation of anandamide production. One study found CBD helped with hallucinations, delusions, lack of emotion, and reduced social functioning. CBD can also benefit those with Parkinson’s disease, and various studies have found CBD can help treat the sleep disturbances and psychosis associated with the disorder without worsening motor symptoms and while improving overall quality of life.

This information has been provided by Leaf Science and approved by our Chief Medical Officer. In tomorrow’s post, we will continue to discuss some of the conditions CBD is able to treat.

Study: CBD Effective As Adjunctive Therapy For Psychosis

Photo Credit: NORML

Photo Credit: NORML

Contrary to the notion that those who use cannabis may develop psychosis, its cannabinoid cannabidiol (CBD) may actually help treat psychosis instead. According to a new study published in The American Journal of Psychiatry, the daily use of CBD as an adjunctive therapy can help those who experience psychotic symptoms as a result of schizophrenia. The six-week randomized trial assessed the adjunctive use of 1000mg plant-derived CBD or placebo in 88 patients with schizophrenia daily. Those who received CBD had lower levels of psychotic symptoms and were more likely to have their clinicians report an improvement in wellness at the end of the trial. CBD also produced minor improvements in cognitive performance and overall functioning. Authors concluded, “These findings suggest that CBD has beneficial effects in patients with schizophrenia… As CBD’s effects do not appear to depend on dopamine receptor antagonism, this agent may represent a new class of treatment for the disorder.”

This information has been provided by NORML and approved by our Chief Medical Officer.

Marijuana's Effects On Your Bones

Photo Credit: Civilized

Photo Credit: Civilized

A cannabinoid found in marijuana, cannabidiol (CBD), may boost bone health by strengthening bones and supporting bone fracture healing. In a study from Israel, rats with mild fractures in their femurs were separated into groups that either healed naturally, received CBD as a therapy, or received both CBD and THC therapies. Both groups that received CBD healed faster than those who healed naturally. THC did not seem to influence the healing process. Researcher Yankel Gabet explains, "We found that CBD alone makes bones stronger during healing, enhancing the maturation of the collagenous matrix, which provides the basis for new mineralization of bone tissue… After being treated with CBD, the healed bone will be harder to break in the future."

This information has been provided by Civilized and approved by our Chief Medical Officer.

CBD for Pain - Part 2

Photo Credit: typographyimages (pixabay.com)

Photo Credit: typographyimages (pixabay.com)

In the previous post, we discussed how Cannabidiol (CBD) could provide safe and effective pain relief Now, Let’s look at some of the conditions for which CBD can reduce pain.

One study from 2007 involving 125 patients found Sativex, an extract containing THC and CBD, significantly reduced pain in patients with allodynia, a rare condition in which non-painful stimulation or touch becomes painful. Sativex was also found to be effective in a 2013 study against cancer-related pain. Another 2014 study found CBD reduced chemotherapy pain without side effects in mice. One study from 2016 found topical CBD was not only effective but that it was also safe in reducing pain and inflammation associated with arthritis, and it produced very few side effects. Many scientific reviews claim CBD can relieve treatment-resistant chronic pain, and one study from 2007 found CBD relieved chronic pain in rats. Many prefer CBD to pharmaceutical medications because it produces much fewer side effects and it has proven well-tolerated. Lastly, CBD may treat the acute and chronic pain associated with multiple sclerosis. One animal study from 2013 found CBD’s anti-inflammatory properties make it a promising pain reliever for those with MS, and another study found administering Sativex to MS patients effectively relieved the neuropathic pain associated with the condition.

This concludes our miniseries on CBD for pain. This information has been provided by Leaf Science and approved by our Chief Medical Officer.

CBD for Pain - Part 1

Photo Credit: typographyimages (pixabay.com)

Photo Credit: typographyimages (pixabay.com)

Cannabidiol (CBD) is a non-psychoactive cannabinoid in cannabis that can can provide safe and effective pain relief without producing many side effects. In this two part series, we’ll discuss how CBD can successfully treat pain, and then continue our discussion with a look at specific conditions in which CBD may help.

Some studies suggest CBD is better at treating chronic and neuropathic pain than it is at treating short-term pain. It’s ability to reduce inflammation also allows it to reduce the pain associated with it. Unlike non-steroidal anti-inflammatory drugs (NSAIDs), which work to block enzymes that produce inflammation, swelling, and pain, CBD acts within the endocannabinoid system. In doing so, it avoids some of the dangerous side effects associated with blocking those enzymes, like risk of ulcers, stomach bleeding, heart attack, and stroke. Some scientists believe CBD may be able to provide pain relief through its interactions with vanilloid receptors. One study from 2012 also found CBD also treated chronic pain by activating glycine receptors in the spinal cord. Although THC is generally considered to be a more successful pain reliever through its direct interactions on CB1 receptors, it is also known for its psychoactive properties, so many may want to avoid the cannabinoid in order to avoid “high” sensations. That said, CBD can also buffer against these side effects, so strains which include both THC and CBD may benefit from THC’s pain relief and CBD’s tempering effects.

This information has been provided by Leaf Science and approved by our Chief Medical Officer. Stay tuned from tomorrow’s post, where we will dive into a discussion about which pain-causing conditions CBD may be able to relieve.

WHO Report: No Public Health Problems Attributable To CBD

Photo Credit: NORML

Photo Credit: NORML

According to a preliminary report released by the World Health Organization’s Expert Committee on Drug Dependence, natural CBD is safe, well tolerated, and does not produce adverse public health effects. The cannabinoid is “not associated with abuse potential” and does not lead to physical dependence. The authors similarly discuss CBD’s therapeutic efficacy on epilepsy, and the preliminary evidence behind its use for Alzheimer’s, cancer, Parkinson’s, and psychosis.

This information has been provided by NORML and approved by our Chief Medical Officer.

CBD and Parkinson's Disease

Photo Credit: Flickr (https://bit.ly/2W1mdDU).

Photo Credit: Flickr (https://bit.ly/2W1mdDU).

Research suggests the non-psychoactive cannabinoid cannabidiol (CBD) may have the ability to treat symptoms associated with Parkinson’s disease because of its neuroprotective and antipsychotic effects. It may also be able to help improve symptoms that interfere with sleep. One study from 2005 found CBD had neuroprotective benefits in animal models of Parkinson’s. The study believed these effects may be the result of CBD’s antioxidant and anti-inflammatory properties. Through the studies, researchers suggested CBD could protect brains from progressive dopamine neuron loss. In 2007, the same researchers found CBD was most effective at protecting neurons if administered immediately after exposure to toxins.

Other studies have found CBD can improve movement impairments, psychosis, sleep disturbances, and quality of life for those with Parkinson’s disease. A study from 2017 found CBD improved movement impairments through blocking the receptor known as GPR6, which allows dopamine levels to increase. A 2009 trial published in the Journal of Psychopharmacology found six patients with Parkinson’s who were given 150 mg/day of CBD for four weeks exhibited remarkable improvements in their psychotic symptoms. The cannabinoid was also safe and well-tolerated. Another trial from 2014 which involved 21 patients found CBD improved quality of life, likely due to the cannabinoid’s antidepressant, anxiolytic, antipsychotic, and sedative effects. A series of case studies found daily doses of 75-300 mg CBD could reduce or eliminate REM sleep behavior disorder in patients.

THC may also help patients with Parkinson’s disease, and one study from 2014 found it improved movement dysfunction and overall movement deficiencies like tremor, rigidity, and slowed movements. It also helped with sleep disturbances and pain. THC on its own is a psychoactive cannabinoid, and can produce paranoia, anxiety, panic attacks, and increase heart rate which could lead to heart attack. So, the cannabinoid alone may not be the preferred cannabinoid for many patients. That said, using a combination of THC and CBD may be appropriate for those users who want the ultimate relief, as CBD buffers against the effects of THC and the two together can provide benefits and can target a wider range of symptoms.

This information has been provided by Leaf Science and approved by our Chief Medical Officer.

What Are CBD Topicals?

Photo Credit: PixaBay

Photo Credit: PixaBay

For patients who want localized relief, CBD topicals may be the most desirable option. CBD topicals include creams, lotions, salves, balms, and oils that are infused with CBD and can be applied to specific areas for targeted symptom relief. Through this vehicle, CBD is absorbed through the skin before interacting with the endocannabinoid system. In rodent models, CBD preparations successfully absorbed through the skin’s tissues and provided effective pain and inflammation relief in a dose-dependent manner. CBD topicals are suggested for pain and inflammation relief, so may be effective for conditions like psoriasis and arthritis. CBD can also be beneficial for skin’s overall health, and its powers as an antioxidant can keep the skin young healthy.

You can determine if topicals may be the most desirable vehicle for you with our app! Through the journaling function, you can monitor and titrate the different aspects of your dosing regimen to figure out what routine provides the best relief. Journaling daily will improve your results.

This information has been provided by Leaf Science and approved by our Chief Medical Officer. This post does not represent an endorsement on behalf of Leaf Science for CannaBest Medical products.

What is Hemp CBD?

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Photo Credit: Full Spectrum University / https://bit.ly/2Edi84e

Hemp CBD is cannabidiol that is derived from the hemp plant as opposed to from the marijuana plant. CBD is a desired cannabinoid due to its ability to benefit a myriad of conditions while not producing any psychoactive side effects. Some parts of the hemp plant are federally legal, making it more widely accessible to patients than CBD derived from marijuana. There is more CBD present in marijuana due to its large amount of resin, so it is easier to extract CBD from marijuana and requires fewer plants. CBD, whether it comes from marijuana or from hemp, is the same molecule, but where it differs is the plant itself. Because of this, CBD taken from marijuana may contain other beneficial cannabinoids and terpenes that may not be present in hemp extractions.

This information has been provided by Leaf Science and approved by our Chief Medical Officer.

The Differences Between THC and CBD

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

Of the more than 100 cannabinoids found in marijuana, the cannabinoids most commonly associated with the plant are Tetrahydrocannabinol (THC) and Cannabidiol (CBD). These cannabinoids interact with the Endocannabinoid System (ECS), a system which is known to regulate pain, appetite, mood, memory, immune response, sleep, and cellular level life cycles. THC will bind directly to CB1 and CB2 receptors in the ECS, with a higher affinity for CB1 receptors, while CBD acts as an indirect antagonist of cannabinoid receptor agonists, and even binds with non-cannabinoid receptors.

Many medical marijuana patients opt for CBD in their routines due to the fact it does not produce psychoactive or euphoric effects like THC. In fact, for those who desire the therapeutic relief that THC offers, CBD can actually buffer against its psychoactive effects, so that the patient can experience symptom relief without unwanted side effects. THC may produce side effects like memory impairment, lowered reaction time, increased heart rate, coordination problems, dry mouth, and red eye. One can’t overdose from THC, but adolescence who consume high amounts of THC may experience long-term psychiatric side effects. CBD, on the other hand, is considered all around well-tolerated and safe, and the only potential mild side effects include dry mouth, light-headedness, and drowsiness. Producers can produce medical marijuana strains with different cannabinoid compositions tailored to the specific needs of patients. That said, many marijuana strains, especially in today’s world of high potency marijuana, contain higher amounts of THC while hemp contains very little THC and strong concentrations of CBD.

This information has been brought to you by Medical Marijuana Inc. and approved by our Chief Medical Officer.

CBD And Its Effects On The Human Body

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

Cannabidiol (CBD) is one of the more prominent and well known cannabinoids in cannabis. Many patients find CBD preferable for its ability to enhance health and wellness without producing the psychoactive high associated with THC and cannabis. To produce therapeutic benefits, CBD interacts with the body’s endocannabinoid system, which is responsible for regulating mood, memory, appetite, pain, immune response, and temperature. Many scientists believe that CBD works best synergistically alongside other cannabinoids and terpenes, even in trace amounts, in what is known as the entourage effect. The amount of time it takes for CBD to begin to take effect is fully dependent on the dose, the vehicle of administration, and other factors that influence the rate of absorption. This can range from minutes to hours. When CBD is ingested, it must be digested before taking effect. Sublingual absorption, however, allows the cannabinoid to bypass digestion and take effect faster. Vaping CBD oil takes effect almost immediately because it is absorbed through the lungs’ alveoli. Topical applications allow for targeted and localized relief that does not rely on entering the blood stream.

This information has been brought to you by Medical Marijuana Inc. and approved by our Chief Medical Officer.

Is It Safe To Take CBD Oil?w

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

Cannabidiol (CBD) is a non-psychoactive cannabinoid praised for its ability to treat a myriad of symptoms while being well tolerated and producing few side effects. The cannabinoid is recognized for its high safety profile, but what exactly does that mean?

CBD is recognized as safe because it is non-toxic for humans and animals, even when administered in high doses, making it next to impossible to overdose on the cannabinoid. One study from the Department of Clinical, Toxicological and Food Sciences Analysis at the University of São Paulo, Brazil, found even doses as high as 1,500 mg/day of CBD were well tolerated. Unlike the cannabinoid THC, CBD is non-psychoactive, making it applicable in treatment regimens where patients desire relief without feeling “high.” CBD also produces few side effects that are generally considered to be mild. Some of these include dry mouth, low blood pressure, wakefulness (except when taken in high doses, in which drowsiness can occur), and inhibition of hepatic drug metabolism, which means it can interfere with the metabolization of certain pharmaceutical medications.

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer.

10 Facts About Cannabidiol (CBD)

Photo Credit: Leaf Science

Photo Credit: Leaf Science

Cannabidiol is one of the better understood cannabinoids of the over 113 known cannabinoids that exist in cannabis. It’s gaining in popularity for its ability to treat a wide range of conditions without producing psychoactive side effects, but how well do you know the cannabinoid? Let’s look at the facts!

Because CBD does not act on the same receptors as THC, it is able to provide a myriad of health benefits without producing the psychoactive high that marijuana is known for. This makes the cannabinoid appropriate for use in pediatric treatment and makes it desirable among health professionals and patients who want symptom relief without any side effects. According to the British Journal of Clinical Pharmacology, CBD is able to act as an antiemetic, anticonvulsant, antipsychotic, anti-inflammatory, anti-oxidant, anti-tumoral and anti-cancer, anxiolytic and antidepressant, and an analgesic.

Although CBD can provide all of these benefits, one of the strengths of cannabinoid is that it is able work alongside other cannabinoids and terpenes to provide maximum relief through what is known as the “entourage effect.” Through this, CBD can actually buffer against the negative side effects of THC, so that patients can experience the therapeutic benefits of that cannabinoid with less severe side effects. CBD’s safety profile is so high that people have even started using it to treat ailments in their pets. Depending on dosage, CBD can either increase wakefulness among users, or provide sedative effects that facilitate sleeping. Larger doses help people stay asleep longer, while small doses help stimulate energy and help people wake up.

This information has been provided by Leaf Science and approved by our Chief Medical Officer.

Neurologist Dr. Carlos Aguirre's Survey Demonstrates CBD's Powerful Effects on Seizures

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

Pediatric neurologist Dr. Carlos G. Aguirre-Velazquez has released continuing results from his clinical study involving the use of CBD oil for seizures relating to tuberous sclerosis complex (TSC). Dr. Aguirre measured the frequency, intensity, and duration of convulsive crises in TSC patient, as well as studied their quality of life, use of prescription drugs, and the long-term sustainability of CBD treatment. The results of his study are positive, with 60% of participants exhibiting clinically significant (60-80%) reductions in the frequency of their seizures with the use of CBD products. Additionally, patients using CBD experienced an improvement in mood, appetite, cognition, and overall quality of life, without experiencing adverse side effects, suggesting CBD can be used consistently while maintaining a high safety profile. Minor side effects like drowsiness and appetite increase existed, but they could improve or dissipate with adjusted doses. Researchers explained, “The experience of parents and patients with medicinal cannabis (CBD), as reported in our survey, suggests that CBD reduced the frequency, intensity, and duration of convulsive crises secondary to TSC.”

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer.

Treating Autism With Cannabis Now Has Scientific Support

Photo Credit: Civilized

Photo Credit: Civilized

A new study has found CBD extract may be able to provide support for those diagnosed with autism. Many researchers attribute the symptoms of Autism Spectrum Disorder (ASD), which include problems in communication, odd social interactions, restricted or repetitive movements, to reduced inhibition in the brain. Now, in a breakthrough study, a team of researchers from the University of Washington has sought to use CBD as a way of restoring inhibition in the brain. Scientists used a genetic mouse model, in which the genes have been mutated in order to produce the symptoms of Dravet Syndrome, which includes inducing spontaneous seizures and exhibiting autism-like behaviors, to determine the effects of CBD on autism, specifically. In the model, mice were offered a choice between interacting with other mice or objects. While mice would usually prefer to spend time with other mice, the autistic-like mice usually have no preference and will split their time equally between the two. Upon receiving small amounts of CBD (about 10-20% of the anti-epileptic dose), the autistic-like mice significantly increased the amount of time they spent with other mice. Additionally, CBD reduced the urge autistic-like mice felt in escaping these social situations, and they exhibited improved performance in regards to the quality of their social interactions.

To understand these results, the researchers recorded electrical signals within the brains of the individual mice. They found CBD blocked the brain receptor GPR55 from interfering with how the brain cells communicated, thereby restoring balance and brain inhibition. The next steps will involve breaking down the barriers that exist as a result of cannabis’ Schedule I status so that researchers can test the effects of CBD on autism in large-scale human models. This information has been provided by Civilized and approved by our Chief Medical Officer.