What Is CBN (Cannabinol) And What Does It Do?

Photo Credit: High Times

Photo Credit: High Times

You may not have heard of cannabinol (CBN), since it’s hardly present in cannabis flowers and does not have as potent of an effect as THC. This weaker potency, however, could be desirable to those who want the benefits of THC without the psychoactive effects. Cannabinol has been touted as one of the most sedative cannabinoids that can be found in cannabis, inducing body relaxation and making users sleepier. Researchers also found that CBD stimulated appetite in rats, allowing them to eat sooner, larger amounts, and for longer durations of time. Another study from 2006 found CBN, as well as several other cannabinoids, could control the growth of cancer cells, and was especially effective at targeting Lewis carcinoma. The cannabinoid also has minor anticonvulsant properties, and can activate the same pain pathways as THC. Cannabinol may slow the onset of ALS, and its antibacterial properties allow it to target MRSA. As a topical, cannabinol may also be effective in treating various skin conditions.

Although CBN is not a powerful psychoactive compound, some studies have found the cannabinoid, when combined with THC, will exacerbate its effects. One study found CBN increases the psychological and physiological effects of THC. This information is controversial, however, and other studies have claimed CBN provided no significant difference in psychoactive effects than THC alone. Still, those who are not looking for any psychoactive effects may want to avoid strains containing high concentrations of these cannabinoids.

To learn more about cannabinol or to discover where to find products containing high concentrations of cannabinol, check out the original post on High Times. This information has been approved by our Chief Medical Officer.

All About Cannabinoids - Part 2

Photo Credit: Toomaj F. Bungs | pexels (https://bit.ly/2I6rtyq)

Photo Credit: Toomaj F. Bungs | pexels (https://bit.ly/2I6rtyq)

In the previous post, we introduced the powerful chemicals in cannabis known as cannabinoids. Now, we will discuss in detail the unique properties found in cannabis.

Most people are aware of tetrahydrocannabinol (THC), which is a cannabinoid that binds with the CB1 receptor in the brain and is responsible for producing the psychoactive effect of feeling “high.” THC is one of the more prevalent cannabinoids in marijuana, and it may be beneficial for patients who need to reduce nausea and vomiting, and pain. Although THC can offer therapeutic benefits, side effects include rapid heart rate, bloodshot eyes, dry mouth, dizziness, sedation, short-term memory, impaired concentration, and in severe cases, panic attack, hallucinations, and vomiting when consumed in large amounts. The other most well known cannabinoid is cannabidiol (CBD). CBD is popular for medicinal purposes because it does not produce a psychoactive effect, and can even buffer against the psychoactive effects of THC. CBD can help those who suffer from anxiety, depression, and schizophrenia, and most famously, pediatric epilepsy. It provides neuroprotective benefits and is known reduce pain and inflammation.

The cannabinoids cannabinol (CBN) is known for its antibacterial and analgesic properties, anticonvulsant and sedative effects, and appetite stimulation. Cannabichromene (CBC), like CBD, does not produce psychoactive effects. CBC acts as an analgesic, an antidepressant, and has antibacterial and antifungal properties. The cannabinoid could help treat those with acne or diarrhea. Cannabigerol (CBG) is a building block for all other cannabinoids, and it is known for providing pain relief, antifungal and antibacterial effects, reduce inflammation, and neuroprotective effects.

This concludes our short series on the cannabinoids in marijuana. To learn more, visit the Leaf Science website. This information has been approved by our Chief Medical Officer.

Cannabinol (CBN): The Natural Sleep Aid in Cannabis

Photo Credit: MassRoots

Photo Credit: MassRoots

Medical marijuana is composed of various cannabinoids known for their therapeutic value, of which THC and CBD are the most well known. Other cannabinoids also provide therapeutic relief, like the cannabinoid cannabinol (CBN). Cannabinol, like THC, activates both CB1 and CB2 receptors. CBN is best known for its ability to act as a powerful sleep aid. Researchers found 2.5-5mg of CBN produced comparable effects to 5-10mg of diazepam, and when CBN was combined with CBD and D9THC, it could induce sleep for six hours without producing psychoactive effects. CBN is also thought to halt cancer growth, stimulate appetite, provide minor analgesia, fight epilepsy, reduce inflammation, act as an anti-bacterial agent, reduce nausea and vomiting, and stimulate bone growth. CBN can also buffer against the psychoactive effects of THC, thereby relieving some of the anxiety for those who are sensitive to THC.

This information has been brought to you by MassRoots and approved by our Chief Medical Officer. 

An In Depth Look at the Medicinal Value of Cannabinol (CBN)

Cannabinol (CBN) results from the break down of THC after its long exposure to oxygen and heat. CBN is mildly psychoactive, but not like its predecessor THC. CBN's anti-inflammatory properties make it a potential therapeutic agent for multiple sclerosis, rheumatoid arthritis, diabetes, allergic asthma, and Crohn's disease. By stimulating appetite, it can help treat cachexia, anorexia, and help those suffering from cancer or HIV/AIDS. CBN is also antibacterial, and when applied topically, it is effective in combatting MRSA. The topical application of CBN lowers ocular tension so it can reduce the risk and progression of glaucoma.

Out of all other cannabinoids, CBN is the most sedative, making it the most powerful cannabinoid for those who suffer from insomnia, sleep apnea, or other sleep disorders. CBN releases calcitonin and gene-related peptides from sensory nerves without impacting the CB1 or CB2 receptors. This means that it can reduce sensitivity to pain on its own, but that it can also work alongside CBD for enhanced pain relief. Research has shown CBN prolongs seizure latency in mice, making it a potential treatment for epilepsy and other seizure disorders. Lastly, CBN is an agonist of CB1 and CB2 receptors, so it is among the cannabinoids that stimulate bone growth, promote bone health, and help patients with bone diseases like osteoporosis.

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

CBN: Stale THC Helps Patients Sleep

Photo Credit: Whaxy

Photo Credit: Whaxy

There are over 111 cannabinoids in the cannabis plant. Everyone tends to know about the most popular cannabinoids, THC and CBD, but there are so many others that are left relatively unknown. Thanks to Whaxy, we get to learn more about these mysterious cannabinoids through various cannabinoid and terpene feature articles. Today we will be highlighting the cannabinoid cannabinol (CBN), which is best known for its use as a sleep aid.

CBN does not have as strong of a psychoactive effect as THC, but it can cause one to feel groggy, dizzy, and confused. This may not sound appealing, but it's these effects that allow it to act as a sleep aid or a replacement for pharmaceutical sedatives when used in high doses. CBN also acts as an analgesic or painkiller, an anti-convulsive, an anti-inflammatory, an antibacterial agent, and a regulator of the immune system. The cannabinoid is especially effective in combatting diseases like Crohn's disease, glaucoma, seizure disorders, fibromyalgia, Parkinson's disease, and neurological disorders. 

To learn more about cannabinol, read the full feature on Whaxy

ALS and Medical Marijuana

You may know ALS as Amyotrophic Lateral Sclerosis. You may know ALS as Lou Gehrig's Disease. Or, you may know ALS because of the ALS Ice Bucket Challenge, the recent social media trend that brought the condition to the public eye. However you think of the neurological condition, everyone knows ALS for its ability to affect a person's motor function in the muscles of organs and limbs. Symptoms of the condition include muscle weakness, muscles spasms, depression, lack of appetite, and debilitating loss of coordination. 

Currently, there is no known cure for ALS and there are few treatment options, but some doctors suggest cannabis can help. ALS patients can benefit from the complex interaction between multiple cannabinoids, including THC, CBD, CBN, THCv, and CBC. Most of the evidence that exists in support of cannabis for ALS is anecdotal, but in 2001 a group of researchers published a review in the American Journal of Hospice and Palliative Care saying a "variety of symptoms caused by ALS can be alleviated via the use of medical marijuana, including pain, spasticity, wasting, drooling, and depression." Other researchers found that THC actually prevented the condition from progressing. 

As with most conditions, there is a substantial need for clinical trials that will help us better understand medical marijuana's ability to treat ALS. For more information on what is already known for medical marijuana and ALS, read this feature written by Whaxy: http://bit.ly/1KVGBcS