CBD and Parkinson's Disease

Photo Credit: Flickr (https://bit.ly/2W1mdDU).

Photo Credit: Flickr (https://bit.ly/2W1mdDU).

Research suggests the non-psychoactive cannabinoid cannabidiol (CBD) may have the ability to treat symptoms associated with Parkinson’s disease because of its neuroprotective and antipsychotic effects. It may also be able to help improve symptoms that interfere with sleep. One study from 2005 found CBD had neuroprotective benefits in animal models of Parkinson’s. The study believed these effects may be the result of CBD’s antioxidant and anti-inflammatory properties. Through the studies, researchers suggested CBD could protect brains from progressive dopamine neuron loss. In 2007, the same researchers found CBD was most effective at protecting neurons if administered immediately after exposure to toxins.

Other studies have found CBD can improve movement impairments, psychosis, sleep disturbances, and quality of life for those with Parkinson’s disease. A study from 2017 found CBD improved movement impairments through blocking the receptor known as GPR6, which allows dopamine levels to increase. A 2009 trial published in the Journal of Psychopharmacology found six patients with Parkinson’s who were given 150 mg/day of CBD for four weeks exhibited remarkable improvements in their psychotic symptoms. The cannabinoid was also safe and well-tolerated. Another trial from 2014 which involved 21 patients found CBD improved quality of life, likely due to the cannabinoid’s antidepressant, anxiolytic, antipsychotic, and sedative effects. A series of case studies found daily doses of 75-300 mg CBD could reduce or eliminate REM sleep behavior disorder in patients.

THC may also help patients with Parkinson’s disease, and one study from 2014 found it improved movement dysfunction and overall movement deficiencies like tremor, rigidity, and slowed movements. It also helped with sleep disturbances and pain. THC on its own is a psychoactive cannabinoid, and can produce paranoia, anxiety, panic attacks, and increase heart rate which could lead to heart attack. So, the cannabinoid alone may not be the preferred cannabinoid for many patients. That said, using a combination of THC and CBD may be appropriate for those users who want the ultimate relief, as CBD buffers against the effects of THC and the two together can provide benefits and can target a wider range of symptoms.

This information has been provided by Leaf Science and approved by our Chief Medical Officer.

What Are CBD Topicals?

Photo Credit: PixaBay

Photo Credit: PixaBay

For patients who want localized relief, CBD topicals may be the most desirable option. CBD topicals include creams, lotions, salves, balms, and oils that are infused with CBD and can be applied to specific areas for targeted symptom relief. Through this vehicle, CBD is absorbed through the skin before interacting with the endocannabinoid system. In rodent models, CBD preparations successfully absorbed through the skin’s tissues and provided effective pain and inflammation relief in a dose-dependent manner. CBD topicals are suggested for pain and inflammation relief, so may be effective for conditions like psoriasis and arthritis. CBD can also be beneficial for skin’s overall health, and its powers as an antioxidant can keep the skin young healthy.

You can determine if topicals may be the most desirable vehicle for you with our app! Through the journaling function, you can monitor and titrate the different aspects of your dosing regimen to figure out what routine provides the best relief. Journaling daily will improve your results.

This information has been provided by Leaf Science and approved by our Chief Medical Officer. This post does not represent an endorsement on behalf of Leaf Science for CannaBest Medical products.

What is Hemp CBD?

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Photo Credit: Full Spectrum University / https://bit.ly/2Edi84e

Hemp CBD is cannabidiol that is derived from the hemp plant as opposed to from the marijuana plant. CBD is a desired cannabinoid due to its ability to benefit a myriad of conditions while not producing any psychoactive side effects. Some parts of the hemp plant are federally legal, making it more widely accessible to patients than CBD derived from marijuana. There is more CBD present in marijuana due to its large amount of resin, so it is easier to extract CBD from marijuana and requires fewer plants. CBD, whether it comes from marijuana or from hemp, is the same molecule, but where it differs is the plant itself. Because of this, CBD taken from marijuana may contain other beneficial cannabinoids and terpenes that may not be present in hemp extractions.

This information has been provided by Leaf Science and approved by our Chief Medical Officer.

CBD for Back Pain

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

Cannabidiol (CBD) is a powerful analgesic that could provided relief for those who suffer from back pain. While the severity of back pain has a wide range, it is one of the most common ailments people suffer, with 80% of adults experiencing back pain at least once in their lives. Research has found CBD provides pain relief by interacting with the body’s endocannabinoid system (ECS), a system responsible for regulating pain and immune response, among other things. CBD can also relieve neuropathic pain by encouraging the release of serotonin, which is a neurotransmitter responsible for regulating pain processing. CBD’s anti-inflammatory properties make it effective in treating a wide variety of pain. Cannabidiol can elicit these analgesic effects without producing unwanted negative side effects, which many find preferable to pharmaceutical medications. CBD has been found effective for treating pain both on its own and in mixtures containing both CBD and THC. Although studies for CBD and back pain are not explicit, its powers to treat other types of pain suggest it could be an effective treatment option for those who suffer from the condition.

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer.

The Differences Between THC and CBD

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

Of the more than 100 cannabinoids found in marijuana, the cannabinoids most commonly associated with the plant are Tetrahydrocannabinol (THC) and Cannabidiol (CBD). These cannabinoids interact with the Endocannabinoid System (ECS), a system which is known to regulate pain, appetite, mood, memory, immune response, sleep, and cellular level life cycles. THC will bind directly to CB1 and CB2 receptors in the ECS, with a higher affinity for CB1 receptors, while CBD acts as an indirect antagonist of cannabinoid receptor agonists, and even binds with non-cannabinoid receptors.

Many medical marijuana patients opt for CBD in their routines due to the fact it does not produce psychoactive or euphoric effects like THC. In fact, for those who desire the therapeutic relief that THC offers, CBD can actually buffer against its psychoactive effects, so that the patient can experience symptom relief without unwanted side effects. THC may produce side effects like memory impairment, lowered reaction time, increased heart rate, coordination problems, dry mouth, and red eye. One can’t overdose from THC, but adolescence who consume high amounts of THC may experience long-term psychiatric side effects. CBD, on the other hand, is considered all around well-tolerated and safe, and the only potential mild side effects include dry mouth, light-headedness, and drowsiness. Producers can produce medical marijuana strains with different cannabinoid compositions tailored to the specific needs of patients. That said, many marijuana strains, especially in today’s world of high potency marijuana, contain higher amounts of THC while hemp contains very little THC and strong concentrations of CBD.

This information has been brought to you by Medical Marijuana Inc. and approved by our Chief Medical Officer.

CBD And Its Effects On The Human Body

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

Cannabidiol (CBD) is one of the more prominent and well known cannabinoids in cannabis. Many patients find CBD preferable for its ability to enhance health and wellness without producing the psychoactive high associated with THC and cannabis. To produce therapeutic benefits, CBD interacts with the body’s endocannabinoid system, which is responsible for regulating mood, memory, appetite, pain, immune response, and temperature. Many scientists believe that CBD works best synergistically alongside other cannabinoids and terpenes, even in trace amounts, in what is known as the entourage effect. The amount of time it takes for CBD to begin to take effect is fully dependent on the dose, the vehicle of administration, and other factors that influence the rate of absorption. This can range from minutes to hours. When CBD is ingested, it must be digested before taking effect. Sublingual absorption, however, allows the cannabinoid to bypass digestion and take effect faster. Vaping CBD oil takes effect almost immediately because it is absorbed through the lungs’ alveoli. Topical applications allow for targeted and localized relief that does not rely on entering the blood stream.

This information has been brought to you by Medical Marijuana Inc. and approved by our Chief Medical Officer.

All About Cannabinoids - Part 2

Photo Credit: Toomaj F. Bungs | pexels (https://bit.ly/2I6rtyq)

Photo Credit: Toomaj F. Bungs | pexels (https://bit.ly/2I6rtyq)

In the previous post, we introduced the powerful chemicals in cannabis known as cannabinoids. Now, we will discuss in detail the unique properties found in cannabis.

Most people are aware of tetrahydrocannabinol (THC), which is a cannabinoid that binds with the CB1 receptor in the brain and is responsible for producing the psychoactive effect of feeling “high.” THC is one of the more prevalent cannabinoids in marijuana, and it may be beneficial for patients who need to reduce nausea and vomiting, and pain. Although THC can offer therapeutic benefits, side effects include rapid heart rate, bloodshot eyes, dry mouth, dizziness, sedation, short-term memory, impaired concentration, and in severe cases, panic attack, hallucinations, and vomiting when consumed in large amounts. The other most well known cannabinoid is cannabidiol (CBD). CBD is popular for medicinal purposes because it does not produce a psychoactive effect, and can even buffer against the psychoactive effects of THC. CBD can help those who suffer from anxiety, depression, and schizophrenia, and most famously, pediatric epilepsy. It provides neuroprotective benefits and is known reduce pain and inflammation.

The cannabinoids cannabinol (CBN) is known for its antibacterial and analgesic properties, anticonvulsant and sedative effects, and appetite stimulation. Cannabichromene (CBC), like CBD, does not produce psychoactive effects. CBC acts as an analgesic, an antidepressant, and has antibacterial and antifungal properties. The cannabinoid could help treat those with acne or diarrhea. Cannabigerol (CBG) is a building block for all other cannabinoids, and it is known for providing pain relief, antifungal and antibacterial effects, reduce inflammation, and neuroprotective effects.

This concludes our short series on the cannabinoids in marijuana. To learn more, visit the Leaf Science website. This information has been approved by our Chief Medical Officer.

Is It Safe To Take CBD Oil?w

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

Cannabidiol (CBD) is a non-psychoactive cannabinoid praised for its ability to treat a myriad of symptoms while being well tolerated and producing few side effects. The cannabinoid is recognized for its high safety profile, but what exactly does that mean?

CBD is recognized as safe because it is non-toxic for humans and animals, even when administered in high doses, making it next to impossible to overdose on the cannabinoid. One study from the Department of Clinical, Toxicological and Food Sciences Analysis at the University of São Paulo, Brazil, found even doses as high as 1,500 mg/day of CBD were well tolerated. Unlike the cannabinoid THC, CBD is non-psychoactive, making it applicable in treatment regimens where patients desire relief without feeling “high.” CBD also produces few side effects that are generally considered to be mild. Some of these include dry mouth, low blood pressure, wakefulness (except when taken in high doses, in which drowsiness can occur), and inhibition of hepatic drug metabolism, which means it can interfere with the metabolization of certain pharmaceutical medications.

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer.

10 Facts About Cannabidiol (CBD)

Photo Credit: Leaf Science

Photo Credit: Leaf Science

Cannabidiol is one of the better understood cannabinoids of the over 113 known cannabinoids that exist in cannabis. It’s gaining in popularity for its ability to treat a wide range of conditions without producing psychoactive side effects, but how well do you know the cannabinoid? Let’s look at the facts!

Because CBD does not act on the same receptors as THC, it is able to provide a myriad of health benefits without producing the psychoactive high that marijuana is known for. This makes the cannabinoid appropriate for use in pediatric treatment and makes it desirable among health professionals and patients who want symptom relief without any side effects. According to the British Journal of Clinical Pharmacology, CBD is able to act as an antiemetic, anticonvulsant, antipsychotic, anti-inflammatory, anti-oxidant, anti-tumoral and anti-cancer, anxiolytic and antidepressant, and an analgesic.

Although CBD can provide all of these benefits, one of the strengths of cannabinoid is that it is able work alongside other cannabinoids and terpenes to provide maximum relief through what is known as the “entourage effect.” Through this, CBD can actually buffer against the negative side effects of THC, so that patients can experience the therapeutic benefits of that cannabinoid with less severe side effects. CBD’s safety profile is so high that people have even started using it to treat ailments in their pets. Depending on dosage, CBD can either increase wakefulness among users, or provide sedative effects that facilitate sleeping. Larger doses help people stay asleep longer, while small doses help stimulate energy and help people wake up.

This information has been provided by Leaf Science and approved by our Chief Medical Officer.

Neurologist Dr. Carlos Aguirre's Survey Demonstrates CBD's Powerful Effects on Seizures

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

Pediatric neurologist Dr. Carlos G. Aguirre-Velazquez has released continuing results from his clinical study involving the use of CBD oil for seizures relating to tuberous sclerosis complex (TSC). Dr. Aguirre measured the frequency, intensity, and duration of convulsive crises in TSC patient, as well as studied their quality of life, use of prescription drugs, and the long-term sustainability of CBD treatment. The results of his study are positive, with 60% of participants exhibiting clinically significant (60-80%) reductions in the frequency of their seizures with the use of CBD products. Additionally, patients using CBD experienced an improvement in mood, appetite, cognition, and overall quality of life, without experiencing adverse side effects, suggesting CBD can be used consistently while maintaining a high safety profile. Minor side effects like drowsiness and appetite increase existed, but they could improve or dissipate with adjusted doses. Researchers explained, “The experience of parents and patients with medicinal cannabis (CBD), as reported in our survey, suggests that CBD reduced the frequency, intensity, and duration of convulsive crises secondary to TSC.”

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer.

Treating Autism With Cannabis Now Has Scientific Support

Photo Credit: Civilized

Photo Credit: Civilized

A new study has found CBD extract may be able to provide support for those diagnosed with autism. Many researchers attribute the symptoms of Autism Spectrum Disorder (ASD), which include problems in communication, odd social interactions, restricted or repetitive movements, to reduced inhibition in the brain. Now, in a breakthrough study, a team of researchers from the University of Washington has sought to use CBD as a way of restoring inhibition in the brain. Scientists used a genetic mouse model, in which the genes have been mutated in order to produce the symptoms of Dravet Syndrome, which includes inducing spontaneous seizures and exhibiting autism-like behaviors, to determine the effects of CBD on autism, specifically. In the model, mice were offered a choice between interacting with other mice or objects. While mice would usually prefer to spend time with other mice, the autistic-like mice usually have no preference and will split their time equally between the two. Upon receiving small amounts of CBD (about 10-20% of the anti-epileptic dose), the autistic-like mice significantly increased the amount of time they spent with other mice. Additionally, CBD reduced the urge autistic-like mice felt in escaping these social situations, and they exhibited improved performance in regards to the quality of their social interactions.

To understand these results, the researchers recorded electrical signals within the brains of the individual mice. They found CBD blocked the brain receptor GPR55 from interfering with how the brain cells communicated, thereby restoring balance and brain inhibition. The next steps will involve breaking down the barriers that exist as a result of cannabis’ Schedule I status so that researchers can test the effects of CBD on autism in large-scale human models. This information has been provided by Civilized and approved by our Chief Medical Officer.

Medical Marijuana and Epilepsy

Photo Credit: Leaf Science/ShutterStock

Photo Credit: Leaf Science/ShutterStock

There is growing evidence suggesting medical marijuana could be a powerful agent in combatting epilepsy, even in its most severe and treatment-resistant forms, and its symptoms. Marijuana acts as an anticonvulsant, and produces antiepileptic effects through its interactions with both the CB1 and CB2 receptors. In recent years, GW Pharmaceuticals has been conducting experiments that have proven their pure CBD extract effectively reduces the frequency and severity of seizures in severe treatment-resistant forms of epilepsy.

Most researcher attribute cannabis’ therapeutic effects for epilepsy to the cannabinoid cannabidiol (CBD). CBD is a non-psychoactive, making it appropriate for use in pediatric care, and it produces very few mild side effects, like dry mouth, diarrhea, sleepiness, and fatigue. CBD can work on its own or work as a powerful supplement to other epilepsy medications, but it may interfere with the processing of other medications in the liver, so patients who choose to use the medication should research its interactions with other medications before beginning a CBD regimen. There is less information regarding the use of tetrahydrocannabinol (THC) for epilepsy, which is a cannabinoid known for its psychocactive activity, and some reports suggest it may exacerbate symptoms. That said, THC may also act as an anticonvulsant, so some researchers think including some amounts of it in one’s regimen may provide optimal relief. In one study, ratios of 20:1 CBD to THC produced maximum seizure relief in patients. More research is needed to better understand which cannabinoids and the amount of each can produce the best relief with the lowest side effects.

This information has been provided by Leaf Science and approved by our Chief Medical Officer.

New Study: Marijuana with CBD Has Less Long-Term Risks Than Other Forms

Photo Credit: Civilized

Photo Credit: Civilized

Many people may desire the use of medical cannabis but fear any negative side effects. With cannabidiol (CBD) gaining in popularity for its high-safety profile and lack of psychoactive side effects, people wonder whether or not the cannabinoid is worth the hype. According to a new study, led by Dr. Ken Mackie from Indiana University, the answer is yes. In the study, scientists injected two groups of mice with tetrahydrocannabinol (THC), with one group only receiving the THC and the other also receiving CBD. Mice who received only THC experienced greater memory impairment and anxiety over the long term, while those who also received CBD did not experience these effects.

Previous studies surrounding THC and CBD have been mixed, but Mackie believes his study is more accurate because “this is the first study in a rigorously controlled animal model to find that CBD appears to protect the brain against the negative effects of chronic THC.” He continues to explain that this experiment "suggests that strains of cannabis with similar levels of CBD and THC would pose significantly less long-term risk due to CBD's protective effect against THC."

More research is left to be desired to understand how CBD is able to exhibit these effects. This information has been provided by Civilized and approved by our Chief Medical Officer.

Study Suggests Higher CBD Levels Could Counteract Any Potentially Harmful Effects of Cannabis

Photo Credit: https://bit.ly/2Rhg2Jb

Photo Credit: https://bit.ly/2Rhg2Jb

Researchers from Indiana University have found equal parts THC and CBD can prevent memory impairment and prevent increased anxiety in mice. The new study has found that higher amounts of CBD could buffer against potentially harmful long-term effects associated with smoking marijuana. In the study, researchers injected mice everyday for three weeks with doses of either THC or CBD, THC and CBD, or neither cannabinoid. When only given THC, mice experienced increased anxiety and memory impairment. When they received equal parts THC and CBD, however, they did not exhibit the same side effects. Lead author Dr. Ken Mackie explains this information "suggests that strains of cannabis with similar levels of CBD and THC would pose significantly less long-term risk due to CBD's protective effect against THC.”

The adolescent and adult mice were divided into five groups, those who received THC only, those who received CBD only, those who received equal parts of both cannabinoids, those who received placebo, and those who received no treatment. Researchers observed immediate reactions after testing, and then tested them again six weeks later. Adolescent mice who received only THC exhibited negative symptoms six weeks later, while adult mice did not, suggesting teenagers may experience side effects that differ from adults. Equal doses of THC and CBD did not affect neither adolescent nor adult mice.

This information has been provided by Merry Jane and approved by our Chief Medical Officer.

CBD Hemp Oil Beneficial for HPV Vaccine Side Effects, Study Suggests

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

A new study published in the Israel Medical Association Journal suggests CBD hemp oil could help reduce the symptoms and improved the quality of life for patients who suffer from adverse side effects like severe somatoform and dysautonomic sydrome after receiving HPV vaccination. Researchers entered the study with the notion that adverse side effects resulting from HPV vaccinations may be related to an imbalance in the endocannabinoid system. Authors of the study, who hailed from the University of Modena and the Reggio Emilia Medical School, wrote, “Due to the absence of a safe and effective therapy for these girls who were living with their families and having to deal with difficult conditions (such as emotional instability, social problems as well as school obligations), and suspecting that an endogenous cannabinoid network imbalance might be responsible for some of the described symptoms, we selected a natural therapeutic approach based on CBD-enriched hemp oil over a 3 month period in our Italian cohort.”

In the open-label study, 12 female patients between the ages 12 and 24 that had an adverse response to HPV vaccinations received sublingual CBD hemp oil drops over the course of three months. Each patient received 25 mg/kg daily, alongside 2-5 mg/ml CBD once a week, until they received the maximum dose of 150 mg/ml CBD per day. Researchers observed the oil presented, “significant benefits in the physical component score, vitality and social role functioning… This study demonstrated the safety and tolerability of CBD-rich hemp oil and the primary efficacy endpoint.” Two patients withdrew from the study claiming they experienced no benefits. While the results are hopeful, the researchers urge for blind clinical research to substantiate these results.

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer.

CBD Improves Quality of Life Measures in Parkinson's Disease Patients, Trial Finds

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

A new study published in the Journal of Psychopharmacology has determined patients suffering from Parkinson’s disease may be able to improve their quality of life and overall well-being with the use of CBD. The double-blind clinical trial, which was conducted by researchers at Brazil’s University of São Paulo, involved 21 patients suffering from Parkinson’s disease without demential or comorbid psychiatric conditions. The patients were separated into three groups, and then given either placebo, 75mg CBD, or 300 mg CBD over the course of six weeks. At five weeks in, researchers tested for motor and general symptoms, well-being and quality of life, and neuroprotective effects. To measure well-being and quality of life, researchers provided patients with the Parkinson’s Disease Questionnaire, which considers mobility, activities of daily living, emotional well-being, stigma, social support, cognition, communication, and bodily discomfort.

Those receiving the more potent dose displayed significant improvements in quality of life and well-being. There were no major differences in motor symptoms and neuroprotective effects between the different groups after 6 weeks, but researcher explained this may be attributed to the small sample size, the short duration of the study, or the fact that many patients were in the early stages of the disease and so had low baseline scores. The study concludes, “Nowadays, most drugs used in the treatment of [Parkinson’s disease] act in the dopaminergic system and little is known about the role of other neurotransmitter systems in the disease… The endocannabinoid system seems to be an important target of investigation, mostly because of its action in those considered as the non-motor symptoms of [Parkinson’s disease and of reports of its possible neuroprotective effects.”

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. You can also access the study here.

42% Of New CBD Users Stop Taking Traditional Medicines

Photo Credit: Civilized

Photo Credit: Civilized

A survey conducted by Brightfield Group and HelloMD has found 42% of CBD users were able to stop the use of traditional medications, ranging from common Tylenol pain relievers to prescription medications like Vicodin. Other findings included 80% of CBD users found the cannabinoid to be extremely effective, less than 3% found it to be ineffectual or slightly ineffective, and 55% or users were female. The study involved 2400 of HellMD’s members.

This information has been provided by Civilized and approved by our Chief Medical Officer.

Cannabis for Cancer: Medicating Without the High

Photo Credit: MassRoots

Photo Credit: MassRoots

Thanks to the various cannabinoids and terpenes found in cannabis, cancer patients may find an alternative treatment option for their conditions without experiencing any psychoactive high. Different combinations of cannabinoids and terpenes could have positive implications for cancer treatment. Although THC produces the high that most consumers associate with marijuana, the properties of CBD and the cannabinoid CBG may be able to buffer against these effects. CBG, like CBD, also offers anti-inflammatory and anti-tumor effects. Researchers at the Technion-Israel Institute of Technology have partnered with CURE Pharmaceutical to better understand the best cannabinoids for cancer-specific treatments. The use of cannabinoids as a supplementary treatment option for those undergoing chemotherapy or radiation could have huge benefits in not only reinforcing the cancer fighting capabilities of these treatments, but also in combatting the horrible side effects that accompany them. 

This information has been provided by MassRoots and approved by our Chief Medical Officer. 

Study Finds CBD Reduces Blood Pressure

Photo Credit: Medical Marijuana Inc. 

Photo Credit: Medical Marijuana Inc. 

A new study published in JCI Insight suggests CBD reduces systolic blood pressure, which could have beneficial implications for cardiovascular disorders. Researchers from the University of Nottingham looked at the cardiovascular effects of a single oral dose of 600mg CBD when compared to placebo in nine healthy male adults averaging around 24 years old. The investigators monitored cardiovascular parameters like blood pressure, heart rate, stroke volume, and skin blood blow, while subjects were at rest and when subjects under went stress tests for two hours.

Researchers concluded CBD reduced systolic blood pressure by an average of 6 mmHg at rest, 5 mmHg before and after stress, and 6 mmHg in response to cold stress. CBD also reduced stroke volume and increased heart rate by about 7 beats per minute, but there was no observed decline in cardiac output. The study determined, “Our data show that a single dose of CBD reduces resting blood pressure and the blood pressure response to stress, particularly cold stress, and especially in the post-test periods. This may reflect the anxiolytic and analgesic effects of CBD, as well as any potential direct cardiovascular effects."

This information has been provided by Medical Marijuana Inc. and approved by out Chief Medical Officer. 

Cannabis Could Be Better For Migraines Than Pharmaceuticals: Study

Photo Credit: Civilized

Photo Credit: Civilized

A new study conducted by researchers at the Interuniversity Center in Florence, Italy, suggests pills containing THC and CBD can reduce migraine pain by 43.5%. Additionally, the medication can help curb stomach-aches and muscle pain. The study involved 79 migraine and cluster headache sufferers who were given an oral dose of medication containing both THC and CBD over the course of three months. Those who suffered from cluster headaches received either  200mg THC-CBD or 25 mg amitriptyline, while migraine sufferers received 200 mg THC-CBD after the onset of acute pain.

Researchers determined the cannabinoid medication was slightly more effective at curbing the frequency and severity of cluster headaches by cutting incidents by 40.4%. In comparison, amitriptyline cut headaches by 40.1%. Cannabis also cut the severity of migraine pain by 43.5%. Lead researcher Dr. Maria Nicolodi explains, “We were able to demonstrate that cannabinoids are an alternative to established treatments in migraine prevention... That said, they are only suited for use in the acute treatment of cluster headaches in patients with a history of migraine from childhood on.”

This information has been provided by Civilized and approved by our Chief Medical Officer.