Cannabichromene and its Benefits

Photo Credit: Leafly

Photo Credit: Leafly

Today let’s take a look at the cannabichromene (CBC), a non-psychoactive cannabinoid with various benefits. CBC does not bind well to CB1 receptors throughout the brain, but it is able to bind with other receptors like the TRPV1 receptor and the TRPA1 receptor, both of which a receptors that play a role in pain perception. When CBC interacts with these receptors, it increases the production of some of the body’s natural endocannabinoids like anandamide.

CBC is a powerful cannabinoids on its own and in conjunction with other cannabinoids. CBC may be the second most powerful cannabinoid to inhibit the growth of new cancer cells, and it inhibits the uptake of the endocannabinoid anandamide, which has been shown to fight breast cancer in vitro and in vivo. CBC has also been found to block pain and inflammation associated with collagen-induced osteoarthritis, and in one animal study, it produced an even greater anti-inflammatory effect alongside THC than the two could produce on their own. CBC may also benefit brain function, and one 2013 study involving mice found the cannabinoid made neural step progenitor cells (NSPCs) more viable. The cannabinoid is also a powerful inhibitor of acne through its anti-inflammatory properties and its ability to suppress excessive lipid production in sebaceous glands. CBC may also produce antidepressant properties when working synergistically alongside THC and CBD.

This information has been brought to you by Leafly and approved by our Chief Medical Officer.

All About Cannabinoids - Part 2

Photo Credit: Toomaj F. Bungs | pexels (https://bit.ly/2I6rtyq)

Photo Credit: Toomaj F. Bungs | pexels (https://bit.ly/2I6rtyq)

In the previous post, we introduced the powerful chemicals in cannabis known as cannabinoids. Now, we will discuss in detail the unique properties found in cannabis.

Most people are aware of tetrahydrocannabinol (THC), which is a cannabinoid that binds with the CB1 receptor in the brain and is responsible for producing the psychoactive effect of feeling “high.” THC is one of the more prevalent cannabinoids in marijuana, and it may be beneficial for patients who need to reduce nausea and vomiting, and pain. Although THC can offer therapeutic benefits, side effects include rapid heart rate, bloodshot eyes, dry mouth, dizziness, sedation, short-term memory, impaired concentration, and in severe cases, panic attack, hallucinations, and vomiting when consumed in large amounts. The other most well known cannabinoid is cannabidiol (CBD). CBD is popular for medicinal purposes because it does not produce a psychoactive effect, and can even buffer against the psychoactive effects of THC. CBD can help those who suffer from anxiety, depression, and schizophrenia, and most famously, pediatric epilepsy. It provides neuroprotective benefits and is known reduce pain and inflammation.

The cannabinoids cannabinol (CBN) is known for its antibacterial and analgesic properties, anticonvulsant and sedative effects, and appetite stimulation. Cannabichromene (CBC), like CBD, does not produce psychoactive effects. CBC acts as an analgesic, an antidepressant, and has antibacterial and antifungal properties. The cannabinoid could help treat those with acne or diarrhea. Cannabigerol (CBG) is a building block for all other cannabinoids, and it is known for providing pain relief, antifungal and antibacterial effects, reduce inflammation, and neuroprotective effects.

This concludes our short series on the cannabinoids in marijuana. To learn more, visit the Leaf Science website. This information has been approved by our Chief Medical Officer.

What is Cannabichromene (CBC)?

Photo Credit: Civilized

Photo Credit: Civilized

Although research surrounding cannabichromene (CBC) is still new, it is thought to be the second most abundant cannabinoid found in cannabis. The cannabinoid is non-psychoactive and offers an array of therapeutic benefits on its own, but it is also an important part of whole plant cannabis therapy.

CBC has antibacterial and anti-fungal properties, and one study dating back to 1981 at the University of Mississippi found CBC had strong antibacterial activity and mild to moderate anti-fungal activity when administered to a variety of bacteria and fungi strains. Additionally, CBC offers relief from pain and inflammation. It is especially effective for treating inflammation in the intestinal tract, and in 2012, researchers from the University of Naples found CBC reduced diarrhea without causing constipation. CBC also can fight acne, and a European team of researchers in 2016 found CBC reduced arachidonic acid and the production of sebum in sebaceous glands. Lastly, CBC may support the growth and viability of neurogenesis, and a 2013 study at the Institute of Biomolecular Chemistry of the National Research Council found CBC had a positive effect on the viability of mouse neural stem progenitor cells (NSPCs).

This information is provided by Civilized and approved by our Chief Medical Officer. 

Part 2: Medicinal Applications of CBC (Cannabichromene)

Photo Credit: Wikimedia Commons

Photo Credit: Wikimedia Commons

In today's post, we will continue our discussion of cannabichromene (CBC) by discussing the different ways it can be used for medicinal relief.

While CBC has not been studied as thoroughly as other cannabinoids, it may be useful in a variety of applications. One study from 2016 found CBC reduced the production of sebum by sebaceous glands, and reduced the effects of arachidonic acid, making it particularly useful in the prevention of acne. CBC also has anti-inflammatory properties that could enhance these effects. Another study from 2012 found CBC reduced inflammation-induced hypermotility without causing hypomotility or constipation, making it an ideal alternative for anti-diarrheal medications that often cause constipation. Scientists have also hypothesize CBC may play a role in regulating bone growth by increasing levels of endocannabinoids, which leads to enhanced osteoclasts. While its anti-cancer effects have not yet been investigated, scientists theorize CBC may contribute to the anti-cancer effects of marijuana by influencing the activity of endocannabinoids like 2-AG and anandamide.

One of the earliest studies involving CBC, dating back to 1981 at the University of Mississippi, found CBC exhibited "strong" antibacterial effects on various gram-positive and gram-negative bacteria. This includes E. coli and staph (S. aureus). It also showed "mild to moderate" effects on various fungi as well. Animal studies have found CBC can reduce edema (swelling) and inflammation of the intestinal tract. Since it fights inflammation without targeting cannabinoid receptors, this effect can be further enhanced when combined with cannabinoids like THC that do target receptors. CBC also reduced pain in animal models, and a study in 2010 found CBC in combination with CBD both fought pain by "interacting with several targets involved in the control of pain" at the spinal level. Another study from the same year at the University of Mississippi found CBC acted as an antidepressant in rat models, contributing to "the overall mood-elevating properties of cannabis." Lastly, studies have found CBC may promote neurogenesis, which is a process that increases the viability of brain cell development. 

This information has been brought to you by Leaf Science and approved by our Chief Medical Officer. 

Part 1: What is CBC (Cannabichromene)?

Photo Credit: Wikimedia Commons

Photo Credit: Wikimedia Commons

Cannabichromene (CBC) is one of the 113 cannabinoids found in cannabis, and while it is lesser known, it is actually the second most prevalent cannabinoid in the marijuana plant. It is a non-psychoactive, and like THC, CBC gets converted from its acidic form when it is exposed to heat through a process called decarboxylation. CBC does not bind well to the cannabinoid receptors in the body, but it is able to bind with a number of other receptors in the body, like vanilloid receptor 1 (TRPV1) and transient receptor potential ankyrin 1 (TRPA1). Activating these receptors increases endocannabinoid presence in the body and interrupts the natural processes that degrade them. This indirectly activates cannabinoid receptors by enhancing receptor activity of naturally-occurring cannabinoids. 

Check back Monday to learn about the various ways CBC can be utilized for medicinal purposes. This information has been provided by Leaf Science and approved by our Chief Medical Officer. 

The Medicinal Value of Cannabichromene (CBC)

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

Cannabichromene (CBC) is one of the many cannabinoids found in cannabis, and research suggests it has analgesic, antidepressant, antimicrobial, anti-inflammatory, anti-proliferative, and anti-anxiety effects while also having the ability to stimulate bone and brain cell birth. When combined with the cannabinoid CBD, CBC can enhance pain relief. CBC promotes neurogenesis, or brain cell birth, which is not only an important process for memory and learning, but also for preventing the decline of growth in the cells, something that is thought to contribute to disorders like depression and Alzheimer's disease. In addition, CBC interacts with CB1 receptors to release chemicals that reduce anxiety and stress levels. 

Cannabichromene reduces inflammation without interacting with cannabinoid receptors. One study has shown CBC reduces gastrointestinal inflammation within mice, making it a potential provider of therapeutic relief Crohn's disease and other inflammatory bowel diseases. The cannabinoid also has antibacterial and antifungal properties, having the ability to combat E. coli and staph infections. Lastly, CBC also inhibits the uptake of anandamide, which is a human-produced endocannabinoid that has anti-cancer benefits. This allows it to remain in the body's system so that it can combat cancer. 

This information has been brought to you by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

ALS and Medical Marijuana

You may know ALS as Amyotrophic Lateral Sclerosis. You may know ALS as Lou Gehrig's Disease. Or, you may know ALS because of the ALS Ice Bucket Challenge, the recent social media trend that brought the condition to the public eye. However you think of the neurological condition, everyone knows ALS for its ability to affect a person's motor function in the muscles of organs and limbs. Symptoms of the condition include muscle weakness, muscles spasms, depression, lack of appetite, and debilitating loss of coordination. 

Currently, there is no known cure for ALS and there are few treatment options, but some doctors suggest cannabis can help. ALS patients can benefit from the complex interaction between multiple cannabinoids, including THC, CBD, CBN, THCv, and CBC. Most of the evidence that exists in support of cannabis for ALS is anecdotal, but in 2001 a group of researchers published a review in the American Journal of Hospice and Palliative Care saying a "variety of symptoms caused by ALS can be alleviated via the use of medical marijuana, including pain, spasticity, wasting, drooling, and depression." Other researchers found that THC actually prevented the condition from progressing. 

As with most conditions, there is a substantial need for clinical trials that will help us better understand medical marijuana's ability to treat ALS. For more information on what is already known for medical marijuana and ALS, read this feature written by Whaxy: http://bit.ly/1KVGBcS

Cancer and medical Marijuana

Cancer comes in a variety of shapes and sizes, but the various cancers that exist all consist of abnormal malignant cells that grow and spread throughout the body. Every year cancer claims the lives of millions on a global scale. There is no known cure for the disease, but various treatments exist, and as research on cannabis expands, we hope to add it to that list of treatment options. 

The National Cancer Institute has claimed, "Studies in mice and rats have shown that cannabinoids may inhibit tumor growth by causing cell death, blocking cell growth, and blocking the development of blood vessels needed by tumors to grow." It has also shown the ability to kill cancer cells without damaging normal cells in the body, unlike other cancer treatment options. Experts say isolating cannabinoids may be insufficient in treating cancer, but cannabinoids like CBC can enhance the efficacy of other cannabinoids like THC and CBD, creating a powerful effect when destroying cancer cells.  

Unfortunately, the research to support this evidence is insufficient. Most of the evidence we rely on is anecdotal, and the majority of what clinical trials exist have either involved non-human species or conducted outside of the U.S. We are in desperate need of more widespread clinical trials that involve a large population of patients and use consistent dosing methods. For a more detailed look at what evidence exists involving medical marijuana and cancer, or for suggestions on specific strains that have a powerful impact in the fight against cancer, take a look at Whaxy: http://bit.ly/1L3z4Hp