Marijuana's Effects On Your Bones

Photo Credit: Civilized

Photo Credit: Civilized

A cannabinoid found in marijuana, cannabidiol (CBD), may boost bone health by strengthening bones and supporting bone fracture healing. In a study from Israel, rats with mild fractures in their femurs were separated into groups that either healed naturally, received CBD as a therapy, or received both CBD and THC therapies. Both groups that received CBD healed faster than those who healed naturally. THC did not seem to influence the healing process. Researcher Yankel Gabet explains, "We found that CBD alone makes bones stronger during healing, enhancing the maturation of the collagenous matrix, which provides the basis for new mineralization of bone tissue… After being treated with CBD, the healed bone will be harder to break in the future."

This information has been provided by Civilized and approved by our Chief Medical Officer.

Medical Marijuana and the Acceleration of Bone Healing

Photo Credit: Marijuana Health Wellness

Photo Credit: Marijuana Health Wellness

A new study from Tel Aviv University and published in the Journal of Bone and Mineral Research suggests CBD-based medicines accelerate the healing of broken bones. In the study from TVU's Bone Research Laboratory, researchers led by Dr. Yankel Gabet administered CBD to rats, whose bones now only healed more rapidly, but also became stronger as an end result. In previous studies, CBD was already found to be a safe medication. Gabet said to the Times of Israel, "...we should continue this line of study in clinical trials to assess its usefulness in improving human fracture healing."

These results are encouraging, but they leave much to be desired when it comes to medical marijuana research. We ask you to journal daily for whatever symptom you're treating, so that we can use your anonymous information to contribute to a better understanding of marijuana in the  medical community. With your help, we can learn more about the safety and efficacy surrounding medical cannabis. This information has been provided in part by Marijuana Health and Wellness and approved by our Chief Medical Officer. 

MMJ for Fibrous Dysplasia

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

Fibrous Dysplasia is an uncommon chronic bone disorder in which fibrous tissue develops in place of normal bone, making the bone weaker and more susceptible to fracturing. Some medications are currently prescribed to decrease the activity of cells that result in dissolving bone, and sometimes surgical treatment is necessary in order to halt the progression of the disorder. The weakened area of bone and the expansion of fibrous tissue causes patients severe pain, and cannabis can reduce these symptoms thanks to its analgesic properties. 

Both THC and CBD effectively lower acute and chronic pain by activating CB1 and CB2 receptors that release neurotransmitters and central nervous system immune cells that manage pain levels. Cannabis not only lowers neuropathic and nociceptive pain levels, but is also effective in managing treatment-resistant pain. In addition, some studies have found cannabis is extremely effective in promoting bone health and facilitating bone healing after fractures. Because fibrous dysplasia is an uncommon disease, along with cannabis' status as a Schedule I drug, there is a general lack of information regarding the use of cannabis for treating this disorder. If you are using medical marijuana to treat your fibrous dysplasia and/or pain symptoms, please journal on a daily basis! We can use the anonymous information we collect to enhance our understanding of medical cannabis and its many applications, allowing us to create and offer accurate guidelines for medical professionals and patients when it comes to creating effective mmj dosing regimens.

This information has been brought to you in part by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

Understanding Cannabidiol (CBD) - Part 2

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

In the previous post, we set up the background of what CBD is and what therapeutic effects it can provide. Now we are going to dive in and discuss specific conditions and the ways CBD can help relieve their symptoms. 

CBD fights the progression of Alzheimer's disease by blocking microglial activation, which provides neuroprotection. By combining neuroprotective, anti-oxidative, and anti-apoptotic effects, CBD decreases the oxidative stress associated with the disease. CBD also slows the onset of Amyotrophic Lateral Sclerosis (ALS) and reduces symptoms of pain, appetite loss, depression, sleeping issues, spasticity, and drooling. Those who suffer anxiety can benefit from CBD's effects on the limbic and paralimbic areas of the brain, reducing subjective anxiety, cognitive impairment, and the discomfort associated with public speaking in those who suffer Generalized Social Anxiety Disorder (SAD). CBD limits the progression of arthritis with its anti-inflammatory properties and anti-arthritic effects that protect the joints. The cannabinoid also supports bone health by enhancing the maturation of collagen and thereby improving the strength and healing process of bones.

Research is revealing how important CBD may be for treating various cancers. CBD has successfully slowed the progression of cancer in animal models, suggesting the cannabinoid would be effective in mediating cancer cell death in humans. It inhibits human breast cancer cell proliferation and invasion, and decreases the gene expression in breast cancer cells, thereby lowering tumor aggressiveness and reducing tumor size. The acidic form of CBD (CBDA) down-regulates invasive human brain cancer cells and prevents its growth. For leukemia specifically, CBD prevented complications that may occur after a stem cell or bone marrow transplant operation. CBD reduces the nausea, vomiting, pain, and appetite loss that cancer treatments produce.

That concludes today's post, but we will continue the discussion of CBD for specific conditions in the next piece. This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

Cannabidiol and Bone Fracture Healing: Promising Data Published on Medical Marijuana

Photo: Marijuana Investor News

Photo: Marijuana Investor News

Evidence continues to mount in support of cannabidiol (CBD) in the treatment of bone fracture healing thanks to 18 scientists from Israel and Sweden. Research has shown CBD can "enhance fracture healing and stimulate Lysyl Hydroxylase (a highly abundant enzyme involved in bone healing) activity in osteoblasts (bone building cells)." Research has been performed on the cannabinoid's effect on bone healing, but never with such a large group of scientists. Marijuana Investor News discusses this new study further. 

The study consisted of three experiments; one that injected THC or CBD into rats with fractured femurs, one that analyzed the effects of an equal part CBD/THC mixture on a fracture callus, and one that looked at the effects of THC and CBD on the expression of osteoblast enzyme lysyl hydroxylase that catalyzes collagen crosslinking.

The first experiment concluded "stimulation of endocannabinoid receptors of bone cells with cannabis ligands improved the rate of bone healing... [and] CBD significantly enhanced the mechanical properties and strength of bone after eight weeks." The second experiment found THC increased the maximal force and stiffness of bone a little more than CBD. Lastly, the third experiment discovered CBD increased mRNA levels of the lysyl hydroxylase gene. "This data is probably the most significant finding in cannabis research to date because it gave scientists insight into the genetic impact of cannabis on the body. Everything starts with genetics and this concrete data gives us a deeper insight into how cannabis influences the body's physiology." 

For a more detailed look at these findings, read guest contributor Fabian Hernandez's piece on MJINews.