Marijuana's Effects On Your Bones

Photo Credit: Civilized

Photo Credit: Civilized

A cannabinoid found in marijuana, cannabidiol (CBD), may boost bone health by strengthening bones and supporting bone fracture healing. In a study from Israel, rats with mild fractures in their femurs were separated into groups that either healed naturally, received CBD as a therapy, or received both CBD and THC therapies. Both groups that received CBD healed faster than those who healed naturally. THC did not seem to influence the healing process. Researcher Yankel Gabet explains, "We found that CBD alone makes bones stronger during healing, enhancing the maturation of the collagenous matrix, which provides the basis for new mineralization of bone tissue… After being treated with CBD, the healed bone will be harder to break in the future."

This information has been provided by Civilized and approved by our Chief Medical Officer.

MMJ for Osteoporosis

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

With osteoporosis, bone tissue is not replaced at the rate that bone tissue is broken down, which results in weakened bone that is at high risk of breaking and fracturing. Symptoms include back pain, poor posture, loss of height, and bone fracture. Osteoporosis is typically treated with medications intended to stimulate bone growth, but these medications can make a patients more susceptible to ulcers and can produce feelings of nausea, abdominal pain, and swallowing difficulties. Now, studies suggest cannabis boosts bone density, strengthens bone tissue, and lowers the risk of osteoporosis. 

Studies have found cannabinoids and the endocannabinoid system (ECS) plays an important role in regulating bone metabolism, and a deficiency in CB1 receptors stimulates bone resorption and reduces bone formation, which accelerates age-dependent osteoporosis. Deficiencies in CB2 receptors also accelerate bone turnover rate. Because of this, it is believed cannabinoids can interact with these receptors to counteract deficiencies and fight osteoporosis. Activating CB1 receptors inhibits the release of norepinephrine, resulting in balanced bone formation and resorption. Similarly, stimulating CB2 receptors, which are prevalent in bone cells, aides bone formation and inhibits resorption. CB2 agonists also help fight postmenopausal bone loss and osteoporosis that results from the surgeries that remove ovaries. Lastly, one study found modulating the ECS with cannabinoids is therapeutic for osteoporosis through the stimulation of bone cell production.

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

New Study Finds Regular Cannabis Use Associated with Lower Body Fat, No Loss in Bone Density

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

A new study from Oregon's Health and Science University have determined regular cannabis use results in lower body fat percentage. The study, which was published in Archives of Osteoporosis, determined of the 4,743 participants between ages 20-59 in the survey, those who used cannabis more than five times a month had a lower body mass index when compared to non-users. Carrie M. Nielson, who led the researchers, wrote, "Heavy users of cannabis had a lower mean BMI compared to that of never users, with a mean BMI being 26.7 kg/m2 in heavy users and 28.4 kg/m2 in never users." Additionally, cannabis use did not produce changes in bone mineral density of lumbar spine or proximal femur. In fact, while bone density decreases with age, cannabis has been found to interact with CB2 receptors to actually boost bone density. Heavy users of cannabis were also more likely to be physically active and for longer periods of time.

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer.  

Medical Marijuana and the Acceleration of Bone Healing

Photo Credit: Marijuana Health Wellness

Photo Credit: Marijuana Health Wellness

A new study from Tel Aviv University and published in the Journal of Bone and Mineral Research suggests CBD-based medicines accelerate the healing of broken bones. In the study from TVU's Bone Research Laboratory, researchers led by Dr. Yankel Gabet administered CBD to rats, whose bones now only healed more rapidly, but also became stronger as an end result. In previous studies, CBD was already found to be a safe medication. Gabet said to the Times of Israel, "...we should continue this line of study in clinical trials to assess its usefulness in improving human fracture healing."

These results are encouraging, but they leave much to be desired when it comes to medical marijuana research. We ask you to journal daily for whatever symptom you're treating, so that we can use your anonymous information to contribute to a better understanding of marijuana in the  medical community. With your help, we can learn more about the safety and efficacy surrounding medical cannabis. This information has been provided in part by Marijuana Health and Wellness and approved by our Chief Medical Officer. 

MMJ for Fibrous Dysplasia

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

Fibrous Dysplasia is an uncommon chronic bone disorder in which fibrous tissue develops in place of normal bone, making the bone weaker and more susceptible to fracturing. Some medications are currently prescribed to decrease the activity of cells that result in dissolving bone, and sometimes surgical treatment is necessary in order to halt the progression of the disorder. The weakened area of bone and the expansion of fibrous tissue causes patients severe pain, and cannabis can reduce these symptoms thanks to its analgesic properties. 

Both THC and CBD effectively lower acute and chronic pain by activating CB1 and CB2 receptors that release neurotransmitters and central nervous system immune cells that manage pain levels. Cannabis not only lowers neuropathic and nociceptive pain levels, but is also effective in managing treatment-resistant pain. In addition, some studies have found cannabis is extremely effective in promoting bone health and facilitating bone healing after fractures. Because fibrous dysplasia is an uncommon disease, along with cannabis' status as a Schedule I drug, there is a general lack of information regarding the use of cannabis for treating this disorder. If you are using medical marijuana to treat your fibrous dysplasia and/or pain symptoms, please journal on a daily basis! We can use the anonymous information we collect to enhance our understanding of medical cannabis and its many applications, allowing us to create and offer accurate guidelines for medical professionals and patients when it comes to creating effective mmj dosing regimens.

This information has been brought to you in part by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

Medical Marijuana for Bone Health

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

The human body constantly breaks down and rebuilds bone, but through age, the body tends to break down bone faster than it rebuilds it. This can result in one of the most common forms of bone diseases, osteoporosis, in which the bones become weak and more susceptible to breaking as a result of breaking down bones faster than it can replace. In addition to age, the amount of calcium in a diet, physical activity, tobacco and alcohol use, gender, body size, race and family history, hormone levels, eating disorders, and the use of certain medications also effect bone density. Now, research is revealing cannabis can help bone density, and therefore strengthen bone tissue and lowering the risk of osteoporosis. 

Osteoblasts within bones contain CB2 receptors that control the growth of bone tissue by stimulating bone growth and inhibiting bone breakdown, and THC has been shown to activate these CB2 receptors. Cannabinoids, even at low levels, activate osteoclasts, increasing bone density and offering relief for bone diseases, which suggest those who suffer bone diseases or those who are at high risk could benefit from regular cannabis treatment, even if they use very little. CBD also supports bone health by facilitating the bone healing process. In one study from 2015, rats who were treated with CBD for eight weeks after sustaining broken leg bones had significantly stronger healed legs than those who lacked CBD treatment. The cannabinoid also enhanced the maturation of collagen, which is the protein in the bone's connective tissue.

This information has been brought to you by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

Understanding Cannabidiol (CBD) - Part 2

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

In the previous post, we set up the background of what CBD is and what therapeutic effects it can provide. Now we are going to dive in and discuss specific conditions and the ways CBD can help relieve their symptoms. 

CBD fights the progression of Alzheimer's disease by blocking microglial activation, which provides neuroprotection. By combining neuroprotective, anti-oxidative, and anti-apoptotic effects, CBD decreases the oxidative stress associated with the disease. CBD also slows the onset of Amyotrophic Lateral Sclerosis (ALS) and reduces symptoms of pain, appetite loss, depression, sleeping issues, spasticity, and drooling. Those who suffer anxiety can benefit from CBD's effects on the limbic and paralimbic areas of the brain, reducing subjective anxiety, cognitive impairment, and the discomfort associated with public speaking in those who suffer Generalized Social Anxiety Disorder (SAD). CBD limits the progression of arthritis with its anti-inflammatory properties and anti-arthritic effects that protect the joints. The cannabinoid also supports bone health by enhancing the maturation of collagen and thereby improving the strength and healing process of bones.

Research is revealing how important CBD may be for treating various cancers. CBD has successfully slowed the progression of cancer in animal models, suggesting the cannabinoid would be effective in mediating cancer cell death in humans. It inhibits human breast cancer cell proliferation and invasion, and decreases the gene expression in breast cancer cells, thereby lowering tumor aggressiveness and reducing tumor size. The acidic form of CBD (CBDA) down-regulates invasive human brain cancer cells and prevents its growth. For leukemia specifically, CBD prevented complications that may occur after a stem cell or bone marrow transplant operation. CBD reduces the nausea, vomiting, pain, and appetite loss that cancer treatments produce.

That concludes today's post, but we will continue the discussion of CBD for specific conditions in the next piece. This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

Understanding Tetrahydrocannabinol (THC) - Part 2

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

In the previous post, we gave you a broad overview of the cannabinoid THC. Now, we will go in depth to discuss the many conditions that can benefit from its use. 

Because THC can lower levels of amyloid-beta peptide and enhance mitochondrial function, the cannabinoid could be effective in the treatment of Alzheimer's and slowing its progression. THC may be able to delay the onset of ALS and prolong the survival of neurons, therefore slowing the disease's progression. It can also treat symptoms of the disease, including appetite loss, pain reduction, depression, and drooling. THC can also help those suffering from anorexia by aiding weight gain, stimulating appetite, and increasing the pleasure that coincides with eating.

Those who suffer from Arnold-Chiaro malformation and syringomyelia can benefit from THC by better managing their symptoms, increasing sleep, improving morale, and decreasing pain. Patients with Arthritis can benefit from THC's anti-inflammatory and analgesic properties. THC also helps those who suffer from autism, not only by improving hyperactivity, lethargy, irritability, stereotypy and inappropriate speech, but also by activating CB2 receptors in order to restore neural communication and proper cell function. Activating the CB2 receptors also allows THC to sustain bone health by stimulating bone growth and inhibiting bone breakdown.

We will continue our discussion of THC in relation to various conditions in the following post. This information has been brought to you by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

An In Depth Look at the Medicinal Value of Cannabinol (CBN)

Cannabinol (CBN) results from the break down of THC after its long exposure to oxygen and heat. CBN is mildly psychoactive, but not like its predecessor THC. CBN's anti-inflammatory properties make it a potential therapeutic agent for multiple sclerosis, rheumatoid arthritis, diabetes, allergic asthma, and Crohn's disease. By stimulating appetite, it can help treat cachexia, anorexia, and help those suffering from cancer or HIV/AIDS. CBN is also antibacterial, and when applied topically, it is effective in combatting MRSA. The topical application of CBN lowers ocular tension so it can reduce the risk and progression of glaucoma.

Out of all other cannabinoids, CBN is the most sedative, making it the most powerful cannabinoid for those who suffer from insomnia, sleep apnea, or other sleep disorders. CBN releases calcitonin and gene-related peptides from sensory nerves without impacting the CB1 or CB2 receptors. This means that it can reduce sensitivity to pain on its own, but that it can also work alongside CBD for enhanced pain relief. Research has shown CBN prolongs seizure latency in mice, making it a potential treatment for epilepsy and other seizure disorders. Lastly, CBN is an agonist of CB1 and CB2 receptors, so it is among the cannabinoids that stimulate bone growth, promote bone health, and help patients with bone diseases like osteoporosis.

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

Cannabidiol and Bone Fracture Healing: Promising Data Published on Medical Marijuana

Photo: Marijuana Investor News

Photo: Marijuana Investor News

Evidence continues to mount in support of cannabidiol (CBD) in the treatment of bone fracture healing thanks to 18 scientists from Israel and Sweden. Research has shown CBD can "enhance fracture healing and stimulate Lysyl Hydroxylase (a highly abundant enzyme involved in bone healing) activity in osteoblasts (bone building cells)." Research has been performed on the cannabinoid's effect on bone healing, but never with such a large group of scientists. Marijuana Investor News discusses this new study further. 

The study consisted of three experiments; one that injected THC or CBD into rats with fractured femurs, one that analyzed the effects of an equal part CBD/THC mixture on a fracture callus, and one that looked at the effects of THC and CBD on the expression of osteoblast enzyme lysyl hydroxylase that catalyzes collagen crosslinking.

The first experiment concluded "stimulation of endocannabinoid receptors of bone cells with cannabis ligands improved the rate of bone healing... [and] CBD significantly enhanced the mechanical properties and strength of bone after eight weeks." The second experiment found THC increased the maximal force and stiffness of bone a little more than CBD. Lastly, the third experiment discovered CBD increased mRNA levels of the lysyl hydroxylase gene. "This data is probably the most significant finding in cannabis research to date because it gave scientists insight into the genetic impact of cannabis on the body. Everything starts with genetics and this concrete data gives us a deeper insight into how cannabis influences the body's physiology." 

For a more detailed look at these findings, read guest contributor Fabian Hernandez's piece on MJINews. 

Study: Medical Marijuana May Help Heal Broken Bones

Medical Marijuana is some sort of a miracle plant, with properties that can treat a long list of ailments, but who knew it could also help heal broken and fractured bones? A study conducted by Tel Aviv University and published in the Journal of Bone and Mineral Research found that when studying mice with mid-femoral fractures, the ones treated with CBD healed significantly quicker than the ones that were not treated with the cannabinoid. The CBD treatment also resulted in healed bones that were stronger and harder to break. It will be interesting to see what research can find when it expands to treating humans who have sustained a broken bone with CBD. For more on the subject, read this article written by Marijuana Investor News: http://bit.ly/1LqlwYl

Study: CBD Administration Enhances Skeletal Healing

A study from the Hebrew University Bone Laboratory revealed the administration of cannabidiol (CBD) leads to improved bone fracture healing. In the study, investigators administered CBD to rats with mid-femoral fractures, and reported, “CBD markedly enhanced the biomechanical properties of the healing femora after 8 weeks.” CBD is considered a safe agent, so we hope this research will advance into an investigation of bone fracture healing in humans. 

http://bit.ly/1NblsIZ