What Are The Medical Benefits of CBD? - Part 2

Photo Credit: NeedPix (https://bit.ly/2XK0i4H)

Photo Credit: NeedPix (https://bit.ly/2XK0i4H)

In today’s post, we’ll continue our discussion of which conditions could benefit from CBD treatment.

We’ll begin with Alzheimer’s disease, which scientists believe CBD could treat or even prevent its onset. A 2013 study found CBD prevented the development of amyloid beta plaques, while another study found CBD promoted the growth of new brain cells that were lost to damage caused by the condition, and that it improved symptoms associated with cognitive deficits. The topical application of CBD may treat acne, and studies have found it can reduce inflammation and the production of sebum oil, as well as halt the development of acne. CBD can also help with psoriasis, and studies have found the cannabinoid can prevent the spread of cells that cause the condition’s patches. CBD may also help cancer patients, not only by reducing the nausea and vomiting associated with chemotherapy, but also by preventing the spread of cancer cells and causing cancer cell death. Studies have also found CBD slows the formation of blood vessels within tumors, thereby blocking nutrients from entering the tumor and slowing its growth.

CBD has also been earning a name lately for treating pain and reducing the need for the harmful opiate medications that are traditionally used. Studies have found CBD reduces inflammation and the sensory perception and emotional effects of pain. Research suggests CBD is more effective at treating long-term neuropathic pain than short-term pain. CBD may protect against heart disease, and studies have found the cannabinoid protects cardiac cells when blood supply to the heart is blocked, stops heart arrhythmia, and reduces cardiac damage when oxygen is block. CBD also reduces heart disease from diabetes by reducing inflammation, oxidative stress, scarring, and cell death. The topical application of CBD can target localized areas of pain caused by arthritis. Studies have found CBD blocks pain and prevents nerve damage from osteoarthritis, as well as uses anti-inflammatory and immunosuppressive effects to blog the condition’s progression. Some studies have found CBD may be able to stabilize mood, something that could be helpful for those suffering from Bipolar Disorder. That said, CBD was only effective during depressive stages, and not during manic phases.

That’s not all! Stay tuned for tomorrow’s post to learn more about which conditions CBD could help. This information has been provided by Leaf Science and approved by our Chief Medical Officer.

What Are The Medical Benefits of Marijuana? - Part 3.

Photo Credits: Leaf Science

Photo Credits: Leaf Science

In the last post, we continued to look at the conditions where medical marijuana is effective. It’s not done yet! We’ll continue the discussion below.

While the relationship between marijuana and heart disease is complicated, and cannabis can actually exacerbate symptoms in some users by increasing heart rate and blood pressure, scientists have found low doses of THC can reduce damage from heart attacks, and CBD can be used as a treatment for cardiovascular disease. Cannabis may also reduce the severity and lessen the impact of a stroke. Although most studies thus far have been animal studies, researchers believe medical cannabis may help treat the symptoms of Huntington’s disease, and one human study found synthetic THC improved motor-related symptoms of the disorder. Animal studies have found cannabis may slow the progression of Amyotrophic lateral sclerosis, and many properties of cannabis could help reduce pain, relax muscles, reduce saliva, stimulate appetite, and induce sleep. Synthetic cannabinoids also improved pain symptoms in fibromyalgia patients, and one survey found patients actually preferred cannabis to any approved pharmaceutical medication.

New support is starting to accumulate for the use of marijuana for Alzheimer’s disease. Marijuana may be able to do so by reducing inflammation and the formation of plaques. Marijuana has been found to alleviate tics and be well tolerated in patients with Tourette’s syndrome. Cannabis topicals are now offered as effective treatments for varying skin disorders, and its anti-inflammatory and anti-itching properties make it effective for the treatment of acne, dermatitis, and psoriasis. Marijuana may also help those who suffer from sleep disorders like insomnia and sleep apnea fall asleep quicker and improve breathing during sleep. Lastly, and probably most well known, is medical marijuana’s ability to treat epilepsy. Specifically, the cannabinoid CBD is well-tolerated and effective in reducing the frequency and severity of seizures.

There are even many more conditions to talk about regarding medical marijuana treatment. Keep reading as we conclude our discussion in the next post! This information has been provided by Leaf Science and approved by our Chief Medical Officer.

Study Shows Marijuana Can Prevent Alzheimer's-Causing Protein From Developing

Photo Credit: Civilized

Photo Credit: Civilized

A new study conducted by David Schubert from the Salk Institute for Biological Studies in California has determined THC may prevent the formation of amyloid proteins which are thought to lead to Alzheimer’s. The study has found THC passes through the bloodstream and enters into the brain where it attaches to neuroreceptors and prevents plaques from forming. Schubert explains, “Although other studies have offered evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer’s, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells.”

This information has been provided by Civilized and approved by our Chief Medical Officer.

Evidence Shows CBD Beneficial for Alzheimer's Disease, Parkinson's Disease, and Multiple Sclerosis

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

According to new research conducted by a team of Italian researchers and published in CNS & Neurological Disorders - Drug Targets, CBD can provide neuroprotection for patients diagnosed with neurological disorders. In the study, researchers looked through laboratory and clinical findings referencing CBD’s effects on neurological conditions, and while more research is left to be desired, they determined, “Pre-clinical evidence largely shows that CBD can produce beneficial effects in [Alzheimer’s disease], [Parkinson’s disease], and [multiple sclerosis] patients, but its employment for these disorders needs further confirmation from well designed clinical studies.” The review only searched through studies involving CBD alone.

This information supports previous studies that suggest CBD has neuroprotective properties that can inhibit the progression of neurological disorders. Additionally, researchers found pre-clinical evidence suggesting CBD has antiepileptic properties and can be effective and beneficial for those diagnosed with treatment-resistant seizure disorders.

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. You can also access the review here.

Cannabis Beneficial for Dementia Symptoms, Pilot Study Finds

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

A recent open-label trial published in The Journal of Alzheimer's Disease and conducted by a team of Israeli researchers from the Israel and Sackler Faculty of Medicine at Tel-Aviv University has determined cannabis extracts containing THC help treat the symptoms associated with dementia and Alzheimer's disease. The team examined the use of THC treatments on 11 patients with Alzheimer's disease over the course of four weeks. After the treatments, the team recorded a significant reduction in the Clinical Global Impression (CGI) scale and in behavioral and psychological symptoms of dementia like agitation, aggression, irritability, apathy, delusions, and sleep. Because the trial was open-label, both researchers and patients were aware of their medical cannabis with THC without the possibility of receiving a placebo. The researchers stated, “Adding [medical cannabis oil] to [Alzheimer’s disease] patients’ pharmacotherapy is safe and a promising treatment option.”

This information adds to a growing list of clinical trials suggesting that cannabis could have beneficial implications for the treatment of Alzheimer's disease. This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. You can also access the study here

More Evidence Indicates CBD is Beneficial for Alzheimer's Disease

Photo Credit: Nick Youngson / Alpha Stock Images  Nick Youngson  /  Alpha Stock Images

Photo Credit: Nick Youngson / Alpha Stock Images Nick Youngson / Alpha Stock Images

According to a new research review published in Frontiers in Pharmacology, CBD produces various therapeutic benefits against Alzheimer's disease. Australian researchers were prompted to review articles that had previously investigated CBD's effects on the disease because they were intrigued by the compound's neuroprotective, anti-inflammatory, and antioxidant properties, all of which could reduce or inhibit the cognitive and functional impairment resulting from Alzheimer's. Some of the in vivo studies reviewed suggested CBD reduced reactive gliosis and the neuroinflammatory response, something that has been linked to neurodegeneration in Alzheimer's. CBD may also promote neurogenesis to reduce deterioration of cognitive functions. Preclinical animal studies suggested CBD reverses and prevents cognitive deficits from developing. Other studies found CBD's effects are further enhanced by THC, and that a combination offers greater anti-dementia effects without producing the psychoactive effects that THC alone would produce.

The review concludes, “The studies reviewed in this mini review provide “proof of principle” for the therapeutic benefits CBD and possibly CBD-THC combinations pose for AD therapy... The studies discussed here provide promising preliminary data and the translation of this preclinical work into the clinical setting could be realized relatively quickly: CBD is readily available, appears to only have limited side effects and is safe for human use.”

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. You can also read the full text of the study here.

CBD Inhibits Plaque-Forming Alzheimer's Proteins, Study Finds

Photo Credit: Medical Marijuana Inc. 

Photo Credit: Medical Marijuana Inc. 

A new study published in the International Journal of Molecular Sciences indicated pretreating cells with CBD inhibited the expression of amyloid-beta proteins, thereby preventing the development of Alzheimer's disease. In the study, a team of Italian researchers led by Rosaliana Libro administered CBD to mesenchymal stem cells derived from gingiva (GMSCs) and found pretreating with CBD caused a downregulation in the genes linked to Alzheimer's. CBD also modified the genes involved in the production of beta-amyloid proteins. Libro explains, “In conclusion, this preliminary in vitro study has demonstrated that GMSCs preconditioned with CBD have better therapeutic potential compared to [control] GMSCs cells, and we believe that their transplantation in the early stage of [Alzheimer’s disease] may play a role in preventing or attenuating the disease onset."

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

Study: Cannabis Beneficial for Alzheimer's by Improving Glucose Consumption in the Brain

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

According to a new study published in Neuropharmacology, cannabis can protect brain cells by encouraging glucose uptake, and therefore energy consumption, which could in turn help manage and treat cognitive degeneration in those who suffer from Alzheimer's disease. Researchers have previously understood glucose uptake as being linked to the worsening of brain conditions like Alzheimer's disease. When fewer proteins move glucose to the brain, Alzheimer's patients suffer from cerebrovascular degeneration, neuropathy, and cognitive dysfunction. This process may even contribute to the development of cognitive decline in the first place. 

In this new animal trial, a team of researchers led by Attila Köfalvi from the Cellular Neurosciences and Biology Center, University of Coimbra, and the Cajal Institute Centre for Biomedical Research in Neurodegenerative Disease found activation of the CB2 receptors using modified THC, without activating the CB1 receptor, enhanced glucose consumption in the brain by about 30%, which helped to protect brain neurons. Köfalvi explains, “Through various laboratory techniques, we conclude that the CB2 receptor, when stimulated by chemically modified THC analogues to interact only with the CB2 receptor without activating the CB1, avoiding the psychotropic effects and keeping beneficial effects, promotes increased glucose uptake in the brain.”

Other studies have found cannabis can benefit Alzheimer's patients in other ways as well, like through the prevention of plaque build up, lowering amyloid-beta levels, and enhancing mitochondrial function. Cannabinoids like CBD also have neuroprotective, anti-oxidative, and anti-apoptotic effects. This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. You can also access the entire text of the study via Science Direct.

Small Doses of Cannabis Slow the Progression of Alzheimer's Disease, Study Finds

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

According to a study conducted by neuroscientists from the University of South Florida and published in the Journal of Alzheimer's Disease, extremely small amounts of THC inhibited the production of amyloid-beta proteins on a cellular model of Alzheimer's disease, suggesting the cannabinoids could benefit those who suffer from Alzheimer's disease. Additionally, THC enhanced mitochondrial function, which helped cells in supplying energy and transmitting signals, and helped in maintaining their health.

Lead author of the study, Chuanhai Cao, PhD, explains, "THC is known to be a potent antioxidant with neuroprotective properties, but this is the first report that the compound directly affects Alzheimer’s pathology by decreasing amyloid beta levels, inhibiting its aggregation, and enhancing mitochondrial function... Decreased levels of amyloid beta means less aggregation, which may protect against the progression of Alzheimer’s disease. Since THC is a natural and relatively safe amyloid inhibitor, THC or its analogs may help us develop an effective treatment in the future.”

This is not the first study suggesting cannabis can help in the treatment of Alzheimer's disease, with earlier studies finding THC breaks down the buildup of beta-amyloid protein plaques and reduces cell inflammation, or that THC restores memory and cognitive abilities. This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

Cannabinoids May Be Effective for Treating Alzheimer's Disease, Finds New Study

Photo Credit: Medical Marijuana Inc. 

Photo Credit: Medical Marijuana Inc. 

Researchers from the Anesthesiology Institute at Cleveland Clinic have determined agonists of the CB2 receptor provide neuroprotective and anti-inflammatory effects that reduce brain cell damage, which could have beneficial implications for those who suffer from Alzheimer's disease. In the animal study, which was published in the European Journal of Pharmacology, researchers administered CB2 agonists which resulted helped to suppress neuroinflammation and enhance the removal of amyloid-beta plaques, which led to an increase in brain cell recovery and an improvement in cognitive performance. Researchers used the CB2 agonist MDA7 to mimic the effects of cannabinoids. 

The researchers right, "CB2 receptors act as a negative feedback regular; when activated by a CB2 agonist, they can help limit the extent of the neuroinflammatory response and the subsequent development of neuronal damage in the central nervous system... Collectively, these findings suggest that [a CB2 agonist] has a potential therapeutic effect in the setting of AD.” This study supports the findings of previous studies involving cannabinoids and Alzheimer's disease, and suggests cannabinoids could also be beneficial for other degenerative neuroinflammatory diseases.  

This information has been provided by Medical Marijuana Inc, and approved by our Chief Medical Officer. You can find the text of the study here

Positive Effects of Medical Marijuana on Alzheimer’s Prevention

Photo Credit: High Times

Photo Credit: High Times

A preclinical study published in the Journal of Alzheimer's Disease suggests low concentrations of THC lowered production levels of beta-amyloid proteins in the brain in a dose dependent manner. These toxic proteins accumulate and form plaques, which are believed to lead to Alzheimer's disease. Because the study used low concentrations of cannabinoids, researchers didn't observe any toxicity and the CB1 receptor was not upregulated. Low doses of THC could also effectively enhance mitochondria function without inhibiting melatonin's enhancement of mitochondria function. The study's abstract concludes, "These sets of data strongly suggest that THC could be a potential therapeutic treatment option for Alzheimer's disease through multiple functions and pathways."

Previous studies have found similar evidence suggesting the neuroprotective properties of THC and other cannabinoids could benefit Alzheimer's. The first study linking positive effects to Alzheimer's treatment and prevention dates back to 2006. Since then, an Israeli study found “adding medical cannabis oil to Alzheimer’s patients’ pharmacotherapy is a safe and promising treatment option" after observing 11 patients living with Alzheimer's for four weeks. Ten participants finished this trial.

This information has been provided by High Times and approved by our Chief Medical Officer. 

 

Scientists Believe Cannabis Could Help Cure Alzheimer's Disease

Photo Credit: Medical Marijuana Inc.

Photo Credit: Medical Marijuana Inc.

According to researchers from the Salk Institute, certain cannabinoids like THC may have the potential to treat dementia and Alzheimer's disease by removing harmful protein plaques in the brain that are associated with dementia disorders like Alzheimer's. These plaques interfere with cell communication and the delivery of nutrients between neurons. Researchers from the Salk Institute administered THC to altered laboratory-grown human neurons that formed plaques and found the cannabinoid effectively broke down the buildup of these plaques and reduced cell inflammation. Because the Salk Institute is federally funded, it faces huge research barriers when it comes to studying cannabis. That said, researchers hope the next steps will be to conduct trials on mice and then, if all goes well, move on to human clinical trials. 

This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer. 

How cannabis treats Alzheimer’s

Photo Credit: https://costculator.com/

Photo Credit: https://costculator.com/

New studies suggest cannabis may be able to protect the brain from the effects of the progressive brain disorder Alzheimer's. One study from the journal Nature: Aging and Mechanisms of Disease suggests THC may be able to remove the plaques caused by the buildup of toxic beta amyloid proteins in the brains that contribute to disrupted brain cell communication and memory loss. Another study in the same journal found cannabis could reduce brain inflammation and therefore prevent nerve cell death.  

A team of scientists from Neuroscience Research Australia also found CBD's ability to stimulate neurogenesis may actually be able to reverse the damage Alzheimer's has on cognition. According to a study in the Journal of Neurochemistry, CBD has antioxidant and neuroprotective properties that promote cell survival by blocking the harmful toxic effects of amyloid bet proteins. Scientists from New Jersey's Monmouth Medical Center also discovered THC can reduce agitation in patients who suffer from Alzheimer's disease. 

This information has been brought to you by Health MJ and approved by our Chief Medical Officer. 

Terpene Series: Linalool

Photo Credit: The Leaf Online

Photo Credit: The Leaf Online

Linalool smells of flowers, especially lavender, and serves as a sleep aid, boosts the immune system, reduces lung inflammation, and provides calming and relaxing relief. The terpene also buffers anxious emotions provoked by THC, making it a potential treatment in psychosis and anxiety. It also restores cognitive and emotional function, which suggests it may be useful in treating Alzheimer's disease.

One study found linalool reduces lung inflammation by blocking carcinogenesis from tobacco inhalation. Cannabis strains high in linalool may also reduce the harm caused by inhaling cannabis smoke as well. Linalool activates immune cells through receptors and pathways, thereby boosting the immune system as well. Another study found linalool reverses the histopathalogical hallmarks of Alzheimer's, and that it could restore cognitive and emotional functions through its anti-inflammatory benefits.

This information has been provided by Medical Jane and approved by our Chief Medical Officer. 

Medical marijuana has potential as Alzheimer's treatment, study says

Photo Credit: Brainstorm Blog

Photo Credit: Brainstorm Blog

A recent study revealed the cannabinoid THC stimulates the removal of toxic plaque from the brain, something that signifies a key feature of Alzheimer's. THC also blocks inflammation that causes damage to neurons in the brain. Senior researcher and professor at the Salk Institute for Biological Studies David Schubert found THC activated cannabinoid receptors, which prevented the accumulation of plaque and the death of nerve cells as well as stopped brain inflammation. Because dying neurons on the brain contribute to memory loss and decreased mental ability, cannabis' ability to prevent cell death could obstruct the progression of Alzheimer's disease. Schubert said, "It is reasonable to conclude that there is therapeutic potential of cannabinoids for the treatment of Alzheimer's disease."

In support of these findings, Dr. David Casarett, chief of palliative care services at Duke University, says "I spoke to many family members of people with mild or moderate dementia who believed that THC or whole-plant marijuana was effective in alleviating the confusion and agitation that sometimes occurs." Additionally, in a 2014 review of marijuana research, Dutch scientists suggest two studies show THC treats behavioral symptoms of dementia. In addition, a small 2016 study of 11 participants found THC decreased delusions, agitation or aggression, irritability, apathy and sleep in Alzheimer's patients.

This information has been provided by CNN and approved by our Chief Medical Officer. 

Study: THC Protects Neurons from Damaging Effects of Alzheimer's Disease

Photo Credit: Whaxy

Photo Credit: Whaxy

New research coming from the Salk Institute has revealed THC can play an important role in the treatment of Alzheimer's disease by preventing its damaging effects on neurons. The study found THC protects neurons from degeneration and reduces the inflammation caused by amyloid beta plaques. The study modified neurons so that they had high amounts of amyloid beta and caused plaque formation as seen in the neurons of Alzheimer's patients. When left untreated, the neurons developed inflammation and died, but when the neurons were exposed to cannabinoids, the plaques and their inflammation was reduced, which prolonged survival. Additionally, the study discovered that the inflammation afflicting Alzheimer's patients is actually caused by the neuron's LOX receptors, which may account for why NSAIDS have proven ineffective as a treatment.

This study is significant because the knowledge that cannabis is effective in treating Alzheimer's along with this new discovery provides insight into the pathology of Alzheimer's and inflammatory diseases that are not responsive to medications. Senior author of the paper Professor David Schubert said, “Although other studies have offered evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer’s, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells.” The researchers hope to continue this research using mice models or clinical trials, as opposed to using neurons. 

This information has been adapted from Whaxy and approved by our Chief Medical Officer. 

 

Study: THC May Help Treat Alzheimer’s Disease

Photo Credit: Marijuana Industry News

Photo Credit: Marijuana Industry News

New research suggests the cannabinoid THC may be able to help prevent and treat Alzheimer's disease. The study, conducted by the Salk Institute, found THC facilitates the removal of amyloid beta proteins, which are toxic and contribute to the development of Alzheimer's. Senior author of the paper, Professor David Schubert, said this study is the first of its kind to "demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells." When nerve cells were exposed to THC, amyloid beta protein levels decreased and the resulting inflammation was eliminated. This preliminary study is a good first step towards researching the effects of cannabis on Alzheimer's disease.

This information has been brought to you by Marijuana Industry News and approved by our Chief Medical Officer. 

Terpenes May Improve Effectiveness of Medical Marijuana

Photo Credit: Medical Jane

Photo Credit: Medical Jane

When it comes to understanding how medical marijuana relieves the symptoms of various conditions, many attribute the effects to cannabinoids, but some may overlook the fact that terpenes enhance these benefits. Terpenes are aromatic chemicals found in the essential oils of plants. Over 20,000 terpenes have been identified, of which 140 have been found in cannabis. Some terpenes are beneficial on their own, but they also work well supplementing other cannabinoids and terpenes. For example, the terpene caryophyllene can directly activate CB2 receptors in the body, allowing it to provide therapeutic benefits on its own. The terpene pinene is a bronchodilator, which has positive effects for asthma patients. Other terpenes, like linalool, can work as a buffer for cannabinoids, like counteracting the anxiety that THC might produce in some patients.

Medical marijuana researcher Ethan Russo believes that these synergistic effects could also be effective in combatting pain, inflammation, depression, addiction, epilepsy, cancer, and infections. For example, Russo believes whole-plant extracts that contain high amounts of the cannabinoid cannabigerol (CBG) and the terpene pinene provide anti-MRSA effects. Additionally, the terpenes pinene, linalool, and limonene in combination with CBD-rich cannabis produces a wide-range of benefits in the treatment of Alzheimer's. Cannabis containing the terpenes myrcene, pinene, and caryophyllene would have a powerful effect in the treatment of addiction. Terpenes can also influence the efficiency of medical marijuana ingestion, especially when it involves inhalation methods. Terpenes have been found to dilate capillaries in the lungs, which is beneficial in enabling cannabinoids to enter the bloodstream. Another terpene, nerolidol, can penetrate the skin, which could help with the absorption of cannabinoids through topical applications.

This information has adapted from Medical Jane and approved by our Chief Medical Officer.

Amyloid Proteotoxicity Initiates an Inflammatory Response Blocked by Cannabinoids

Photo Credit: Marijuana Business Daily

Photo Credit: Marijuana Business Daily

New research published in the journal Nature suggests THC and other cannabinoids fight aggregating proteins, like beta amyloid, which are found within neurons, increase with age, and have been linked to the development of Alzheimer's. In this study, David Schubert and other researchers at the Salk Institute found that intracellular beta amyloid produces a toxic inflammatory response that damages the cell. Researchers then found that when cannabinoids like THC were introduced, they stimulated the removal of intraneuronal beta amyloid proteins, which blocked the inflammatory response and protected the cell.

Because of the difficulties associated with researching medical marijuana, a Schedule I substance, Schubert used lab-grown tissue cultures that mimicked the expression of intracellular amyloid proteins in a central nervous system nerve cell in the distinct form of nerve cell death. In this way, Schubert only needed microscopic amounts of THC for his study. With the reclassification of medical marijuana, these research barriers will be knocked down, which would allow for more in depth clinical trials that could revolutionize our understanding of medical marijuana and the effect it has on Alzheimer's and a plethora of other conditions. 

This information has been brought to you by Marijuana Business Daily and the journal Nature, and this post has approved by our Chief Medical Officer.

 

Medical Marijuana Research Surrounding Alzheimer's Disease

Photo Credit: Medical Marijuana, Inc.

Photo Credit: Medical Marijuana, Inc.

Alzheimer's disease is a form of dementia in which brain cells degenerate and die, resulting in the progressive destruction of memory, behavior, and thinking. Hallmark signs of the disease include plaques and tangles building up within the brain and interfering with cell communication and nutrient transport, which contributes to the death of brain cells. Symptoms begin with mild confusion and forgetfulness, but over time memory loss persists and worsens and causes patients to have problems or difficulty finding the right words, concentrating, thinking, and experience depression, anxiety, social withdrawal, mood swings, and irritability. Current pharmaceutical treatment options are only temporary, but now studies show Cannabis could help.

Studies have determined the cannabinoids THC and CBD have the potential to reduce the buildup of plaques and tangles, therefore combatting the early stages of Alzheimer's. THC also lowers amyloid-beta levels and enhances mitochondrial functions, and it prevents amyloid beta aggregation giving it the potential to slow the progression of the disease. CBD modulates microglial function, a contributor to tangles in the brain, and controls neuroinflammation. CBD also improves the rate of survival of cells through neuroprotective, anti-oxidative, and anti-apoptic effects against the toxicity caused by beta-amyloid function, making it a potential treatment option for Alzheimer's patients. Researchers previously related a lack of glucose uptake in the brain to the cause of Alzheimer's, and cannabis is able to promote the uptake of glucose in the brain. THC alone enhances cerebral glucose uptake by about 30%.

With all of these therapeutic benefits, cannabis could serve as a multi-faceted treatment option for those who suffer from Alzheimer's. This information has been provided by Medical Marijuana, Inc. and approved by our Chief Medical Officer.