Is More CBD Better? The Science Behind CBD Dosing for Anxiety and Other Conditions

Photo Credit: Leafly

Photo Credit: Leafly

Cannabidiol (CBD) is famed for its ability to fight epilepsy and buffer against the side effects of THC, among other things. So the question begs to be asked - is more CBD necessarily better? In short, no, and like most medications, the efficacy medical marijuana is dependent on a variety of factors including its dosage. This is known as the “inverted-U” effect, and it’s not uncommon among medications that, like CBD, affect multiple brain receptors. Of published toxicology articles, 37% report a degree of inverted-U responses, which reflects differential drug effects on the brain. CBD is applicable for a wide spectrum of treatments, including pain, anxiety, PTSD, and more, suggesting it has a plethora of brain and body targets.

At low doses, CBD can prevent endocannabinoids and phytocannabinoids from binding with receptors in the nervous system, which may be why it is effective at blocking some of the side effects produced by THC. Additionally, low to moderate doses of CBD are more effective at treating anxiety, as was suggested in one animal study from 1990 where CBD became less effective as an anti-anxiety medication as the dosage increased. These results were supported by human trials, in which low to moderate doses of CBD eased the stresses of social anxiety disorder and public speaking. CBD treats anxiety at about 25% of the amount required to treat epilepsy, showing CBD is effective at much higher doses for this condition.

This is why titrating CBD is essential in determining the perfect amount to experience symptom relief, and our app can help. Journaling daily on our app allows you to keep track of how you’re dosing so you can understand which aspects of your regimen are working, and which aspects of your regimen are not. This information has been provided in part by Leafly and approved by our Chief Medical Officer. This post does not represent an endorsement on behalf of Leafly for CannaBest Medical.