Cannabinoid Receptor-1 (CB-1) & THC

Photo Credit: High Times

Photo Credit: High Times

We know that the cannabinoids in cannabis are able to produce their therapeutic relief by interacting directly or indirectly with the cannabinoid receptors found within the endocannabinoid system, but how exactly does this work? Well, for the cannabinoid tetrahydrocannabinol (THC), the chemical can bind directly the cannabinoid receptor-1 (CB-1). The CB-1 receptor is part of a class of proteins called the g-protein coupled receptors (GPCRs), which are responsible for managing cellular signal transduction to communicate between cells. The proteins are so important, in fact, that they account for 60% of drug targets. The CB-1 receptor is involved in combating varying diseases and abnormalities, including Alzheimer’s, epilepsy, and obesity.

Researchers have recently discovered that their are two types of agonists that bind to and activate the CB-1 receptors, one being very similar in structure to THC. With this information, we will not only be able to better understand how the receptor moves, but also why THC and other cannabinoids are able to produce such positive effects within the body.

This information has been provided by High Times and approved by our Chief Medical Officer.