In our previous post we established the link between Marijuana and serotonin. Now, let’s see what this means in relation to its effects on the body. Researchers suspect the relationship between marijuana and serotonin is what makes it responsible for elevating mood, and benefiting anxiety and depression. Serotonin is an important regulator of mood, emotion, and stress, and when its levels are insufficient, it could cause mental health disorders like anxiety and depression.
One study from 2016 found a drug similar to CBD blocked enzymes that break down endocannabinoids in mice, which resulted in an antidepressant effect. When the mice received a chemical that blocks serotonin, these effects went away, suggesting CBD’s effects on mood may be linked to the serotonergic system. Back in 2006, when the cannabinoid receptor blocker rimonabant was introduced into the market to combat obesity, it was found that these blockers also unintentionally blocked serotonin, thereby causing depression and anxiety in those who took the medication. A study from 2015 also found genetically altered mice who did not have CB1 receptors in their serotonin neurons exhibited increased anxiety. Lastly, a 2011 study found heightened levels of natural cannabinoids increased the efficacy of antidepressants, and that blocking CB1 receptors prevented the antidepressants from working at all.
This concludes our posts on the relationship between serotonin and cannabis, and what this means for us. This information has been provided by Leaf Science and approved by our Chief Medical Officer.