With osteoporosis, bone tissue is not replaced at the rate that bone tissue is broken down, which results in weakened bone that is at high risk of breaking and fracturing. Symptoms include back pain, poor posture, loss of height, and bone fracture. Osteoporosis is typically treated with medications intended to stimulate bone growth, but these medications can make a patients more susceptible to ulcers and can produce feelings of nausea, abdominal pain, and swallowing difficulties. Now, studies suggest cannabis boosts bone density, strengthens bone tissue, and lowers the risk of osteoporosis.
Studies have found cannabinoids and the endocannabinoid system (ECS) plays an important role in regulating bone metabolism, and a deficiency in CB1 receptors stimulates bone resorption and reduces bone formation, which accelerates age-dependent osteoporosis. Deficiencies in CB2 receptors also accelerate bone turnover rate. Because of this, it is believed cannabinoids can interact with these receptors to counteract deficiencies and fight osteoporosis. Activating CB1 receptors inhibits the release of norepinephrine, resulting in balanced bone formation and resorption. Similarly, stimulating CB2 receptors, which are prevalent in bone cells, aides bone formation and inhibits resorption. CB2 agonists also help fight postmenopausal bone loss and osteoporosis that results from the surgeries that remove ovaries. Lastly, one study found modulating the ECS with cannabinoids is therapeutic for osteoporosis through the stimulation of bone cell production.
This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer.