Part 2: Medicinal Applications of CBC (Cannabichromene)

Photo Credit: Wikimedia Commons

Photo Credit: Wikimedia Commons

In today's post, we will continue our discussion of cannabichromene (CBC) by discussing the different ways it can be used for medicinal relief.

While CBC has not been studied as thoroughly as other cannabinoids, it may be useful in a variety of applications. One study from 2016 found CBC reduced the production of sebum by sebaceous glands, and reduced the effects of arachidonic acid, making it particularly useful in the prevention of acne. CBC also has anti-inflammatory properties that could enhance these effects. Another study from 2012 found CBC reduced inflammation-induced hypermotility without causing hypomotility or constipation, making it an ideal alternative for anti-diarrheal medications that often cause constipation. Scientists have also hypothesize CBC may play a role in regulating bone growth by increasing levels of endocannabinoids, which leads to enhanced osteoclasts. While its anti-cancer effects have not yet been investigated, scientists theorize CBC may contribute to the anti-cancer effects of marijuana by influencing the activity of endocannabinoids like 2-AG and anandamide.

One of the earliest studies involving CBC, dating back to 1981 at the University of Mississippi, found CBC exhibited "strong" antibacterial effects on various gram-positive and gram-negative bacteria. This includes E. coli and staph (S. aureus). It also showed "mild to moderate" effects on various fungi as well. Animal studies have found CBC can reduce edema (swelling) and inflammation of the intestinal tract. Since it fights inflammation without targeting cannabinoid receptors, this effect can be further enhanced when combined with cannabinoids like THC that do target receptors. CBC also reduced pain in animal models, and a study in 2010 found CBC in combination with CBD both fought pain by "interacting with several targets involved in the control of pain" at the spinal level. Another study from the same year at the University of Mississippi found CBC acted as an antidepressant in rat models, contributing to "the overall mood-elevating properties of cannabis." Lastly, studies have found CBC may promote neurogenesis, which is a process that increases the viability of brain cell development. 

This information has been brought to you by Leaf Science and approved by our Chief Medical Officer.