Scientists from the Nottingham University's Children's Brain Tumor Research Centre aim o find out whether or not CBD could be beneficial in treating brain tumors in children. The studies that already exist are all preclinical trials, but they have found CBD reduces mitochondrial oxidative metabolism to reduce the viability of cells that make up tumors and inhibit their progression in animal and culture models. The study underway involves administering CBD to to laboratory grown cells made from ependymoma and glioma tumors over the course of seven days. Then, the spreading behavior of the treated and untreated cells will be compared using cell staining. The professor leading the study, Professor Richard Grundy, says, “We expect the cells – brain tumor and normal brain – grown in our standard conditions to be healthy and actively dividing. We expect that normal brain cells grown in cannabidiol will remain healthy. However, we expect the brain tumor cells grown in cannabidiol to stop growing and die.”
With the rates of cancer diagnosed in children has slightly increased in recent decades, finding more effective treatment methods that are not as toxic as chemotherapy and radiotherapy is desired. Grundy explains, “New ways to treat childhood brain tumors are urgently needed to extend and improve the quality of life in malignant brain tumor patients, so we are excited at the prospect of testing the effect of cannabidiol on brain tumor cells.”
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