Cannabinol (CBN) is one of the 113 identified therapeutic cannabinoids found in marijuana, which not only interacts with the endocannabinoid system to provide its own unique effects, but which also boosts the effects of other cannabinoids like CBD and THC. Because CBN does not fit well with CB1 receptors and has difficulty binding with CB2 receptors, CBN produces only minor psychoactive effects if produced at all. CBN is present in cannabis in very small proportions, and is produced by the degradation of THC after exposure to high temperatures or after aging in improper storage. Researchers have found CBN has strong antibacterial properties, and in one study it showed strong antibacterial effects against strains of antibiotic-resistant MRSA. CBN may also act as an anticonvulsant, although other cannabinoids like CBD remain more potent as an anticonvulsant. CBN may combat inflammation by influencing immune cells to produce anti-inflammatory effects and by altering levels of the compounds that cause inflammation.
Cannabinol may also increase appetite, according to rodent models in which rats receiving CBN ate larger amounts of food for longer periods of time and more frequently. In Lewis lung carcinoma, researchers have found CBN is effective at reducing tumor growth. CBN may also be effective at reliving pain through stimulating the release of peptides from sensory nerves, which decreases sensations of pain. When combined with THC, CBN may be able to enhance effects of sedation and promote more effective sleep. CBN may also act as a vasorelaxant, so that it relaxes blood vessel walls and thereby lowers blood pressure. Lastly, CBN may recruit stem cells from bone marrow to help heal bones. CBN increases fibroblast cells, making it beneficial for the bone-healing process.
This information has been provided by Leaf Science and approved by our Chief Medical Officer.