Terpenes and the "Entourage Effect"

Photo Credit: Derrylwc (Wikimedia/http://bit.ly/2qoIauV

Photo Credit: Derrylwc (Wikimedia/http://bit.ly/2qoIauV

We know about how cannabinoids interact with each other through whole-plant cannabis therapy in what is known as the "entourage effect," but how does this relate to terpenes? There are around 200 terpenes that have been discovered in cannabis, and Dr. Ethan Russo discussed the wide-ranging therapeutic attributes of terpenoids in the September 2011 issue of the British Journal of Pharmacology. One example is the terpenoid beta-caryophyllene, which found in cannabis as well as leafy vegetables, herbs, and the oil of black pepper. The terpene binds with the CB2 receptor and is known to be gastro-protective, anti-inflammatory, beneficial for treating some ulcers, and a therapeutic compound for combating auto-immune disorders. 

Terpenoids and cannabinoids both increase blood flow, enhance cortical activity, and kill respiratory pathogens. According to Dr. Russo, cannabinoids and terpenoids can work together to "produce synergy with respect to treatment of pain, inflammation, depression, anxiety, addiction, epilepsy, cancer, fungal and bacterial infections." Additionally, terpenes and CBD can work to buffer the effects of THC, so that patients can experience the benefits of whole-plant cannabis therapy without experiencing psychoactive side effects. 

To learn more, read this article on Project CBD. This information has been approved by our Chief Medical Officer.