β-Caryophyllene: A Terpene For Anxiety and Depression?

Photo Credit: Wikimedia Commons

Photo Credit: Wikimedia Commons

Beta-caryophyllene, a terpene found in the essential oils of cannabis and other plants, may have positive effects on anxiety and depression, study finds. In one study from 2008, German researchers found the terpene also acts in similar ways to cannabinoids in that it has the ability to bind with CB2 receptors throughout the body. Now, a new study published in the journal Physiology & Behavior suggested the terpene may treat anxiety and depression in mice.

The authors from the United Arab Emirates University wrote, “The present study has clearly demonstrated the anxiolytic and anti-depressant effect of β-caryophyllene and its underlying mechanism in a CB2 receptor-dependent manner in rodents...The results also support the involvement of the CB2 receptor in the regulation of emotional behavior and suggest that this receptor could be a relevant therapeutic target for the treatment of anxiety and depressive disorders.” 

This information has been provided by Leaf Science and approved by our Chief Medical Officer.