A study published in the journal Psychopharmacology suggests small amounts of tetrahydrocannabinol (THC) and cannabidiolic acid (CBD-A) could effectively treat nausea and stimulate appetite for patients undergoing chemotherapy. According to the researchers, the “administration of subthreshold doses of THC (0.5 and 1 mg/kg) or CBDA (0.5 and 1 μg/kg) significantly suppressed acute nausea-induced gaping, whereas higher individual doses of both THC and CBDA were maximally effective" for acute nausea.
The study also found the administration of higher doses of both THC and CBDA also enhanced positive hedonic reactions stemming from saccharin solution during conditioning. For anticipatory nausea, combined subthreshold doses of THC (0.1 mg/kg) and CBDA (0.1 μg/kg) reduced contextually elicited conditioned gaping. Researchers determined, “Oral administration of subthreshold doses of THC and CBDA may be an effective new treatment for acute nausea and anticipatory nausea and appetite enhancement in chemotherapy patients.”