Scientists examining the effects of medical marijuana for the treatment of refractory epilepsy in two legalized states found the medication reduced seizure frequency in 86% of the 272 patients involved. The study, which was led by Dustin Sulak, Russell Saneto, and Bonnie Goldstein was published in Epilepsy & Behavior. Of the participants, 10% experienced complete seizure freedom, 28% experienced a 76-99% reduction in seizures, 17% experienced a 51-75% reduction, 18% experienced a 26-50% reduction, and 15% experienced between 1-25% seizure reduction. Only minor adverse side effects were reported, and patients also reported an increased alertness as a benefit. Only 14% found cannabis was ineffective for seizure treatment. Researchers hope for more research involving cannabis and epilepsy so that they can better understand the dose-response relationship with cannabinoids and seizures. This study found a non-linear dose-response relationship, meaning a higher dose is not always more effective.