Terpinolene, also found in sage and rosemary, smells mainly of pine with herbal and floral notes. The terpene is a central nervous system depressant, allowing it to induce sleep or drowsiness and reduce psychological excitement or anxiety. It also reduces the protein expression of AKT1 in K562 cells and ihibits cell proliferation involved in human cancers. Another terpene, camphene, smells of damp woodlands and firs, and could play a critical role in cardiovascular diseases. One study found camphene reduces plasma cholesterol and triglycerides in hyperlipidemic rats, something that plays a large role in heart disease.
There are three similar terpenoids that make up what is known as terpineol, a terpene that smells like lilacs and flower blossoms. Cannabis strains high in pinene also tend to exhibit high levels of terpineol. Terpineol has calming and relaxing effects, and exhibits antibiotic, AChe inhibiting, antioxidant, and antimalarial properties. The last terpene we will discuss today is Pulegone, which is only a minor component of cannabis. One ethnopharmacology study suggests the terpene may have sedative and fever-reducing properties, as well as alleviate the side effects of short-term memory loss that can be caused by high levels of THC.
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