A recent study from the Universidad de Catabria researched the effects of cannabidiol (CBD) on depression. Cannabis can react with endocannabinoid receptors in the brain and body, and CBD specifically has been found to produce an effect on serotonin and glutamate levels, which are two neurotransmitters often targeted as a biological cause of depression. The study involved an OBX mouse model that is often used to simulate depression in humans. The model involves removing part of the mouse's brain in order to trigger depression symptoms.
Within 30 minutes of administering CBD, mice became less hyperactive, which might present as anxiety in humans, and within a week the mice began to enjoy sugar again, representing a human's desire for enjoyment. Both normal mice and OBX mice witnessed an immediate increase in glutamate levels, but only mice who had undergone the OBX surgery experienced increased serotonin levels, suggesting the response to CBD was linked to the conditions of the brain. This information is promising, not only because CBD has the potential to treat depression, but also because the effects of CBD appear to have been immediate, something that is not the case for pharmaceutical medications.
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