Residual limb pain (RLP) refers to cramping, aching, burning, or sensations of hot and cold that develop at the site of an amputation. Current treatments include prescription pain medications and therapies targeting the underlying cause of the pain, and studies suggest cannabis may help. Studies have found cannabis has analgesic, anticonvulsant, and antidepressant properties, which suggests cannabis could be effective for patients who suffer from RLP. One study found 67.7% of amputees experience RLP, and 25% of those patients reported extremely bothersome pain. Both THC and CBD interact with cannabinoid receptors within the endocannabinoid system in order to manage pain levels, making it a powerful pain reliever even when it comes to treatment-resistant pain.
For patients whose RLP results from diabetes, cannabis can help. Cannabis has been found to have an inverse relation with diabetes, and one study found CBD helps reduce pro-inflammatory cytokines in the bloodstream and the incidence of diabetes in non-obese mice. CBD also curtailed manifestations of the disease, and of the mice experiencing the latent diabetes stage or exhibiting diabetic symptoms who were treated with CBD, only 30% actually developed diabetes. Additionally THC stimulates bone formation and inhibits bone breakdown, suggesting cannabis would help prevent patients with residual limb pain from developing osteoporosis. Additionally, cannabinoids effectively activate human osteoclasts even when administered in low doses.
This information has been provided by Medical Marijuana Inc. and approved by our Chief Medical Officer.