A migraine is a severe type of headache in which a specific area of the head throbs and pulses. Migraines can also produce symptoms of nausea, vomiting, and sensitivity to light and sound. Some research suggests migraines result from fundamental neurological abnormalities cause by genetic mutations in the brain. The fluctuation in neuronal activity might affect the trigeminovascular system, resulting in an inflammatory response that produces pain.
The use of cannabis for the treatment of migraines is nothing new. In fact, it was the most prominent migraine remedy used by physicians between 1874 and 1942. Now, research has shown cannabis can both reduce the frequency of migraines and provide pain relief. Both CBD and THC interact with cannabinoid receptors in the endocannabinoid system to inhibit trigeminovascular system responses, which in turn restricts the inflammation that causes migraine pain. In a 2016 study, 103 out of 121 participants diagnosed with migraines witnessed a decrease in migraine frequency from an average of 10.4 a month to 4.6 a month with the use of medical marijuana. In another study, the findings suggested migraines may result from a dysfunction of the endocannabinoid system, leading researchers to conclude the activation of CB1 and CB2 receptors would correct this dysfunction and therefore prevent migraine pain.
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