THCV, or tetrahydrocannabivarin, is molecularly similar to THC, and both molecules fit into the same receptors in the central nervous system and immune system, but THCV does not offer the same intense psychoactive effect that THC is known for producing. While THCV may not be very well known, it is actually one of the more common cannabinoids, and can make up almost half of the cannabinoids by volume in certain strains of cannabis. THCV is not lacking in medical efficacy, and it is suggested it can offer relief for a variety of conditions, including epilepsy and PTSD. THCV is also being studied as a potential therapy for treating obesity and related eating disorders because it acts as an appetite suppressant.
Now, evidence suggests that THCV also acts as a buffer for the psychoactive effects of THC. A new study published in 2015 in the Journal of Psychopharmacology found THCV was able to buffer adverse side effects of THC, like reducing paranoia, decreasing memory impairment, and preventing rapid increases in heart rate. The study also found patients could not discern a difference between THCV and a placebo, meaning THCV does not carry the psychoactive effects of THC.
As states legalize medical marijuana and research advances, we are learning much more about the synergistic interactions among the many cannabinoids in cannabis. This information has been provided by Whaxy and approved by our Chief Medical Officer.