As the medical marijuana movement advances, many states are implementing High CBD or CBD-only laws in order to reduce the potential psychoactive effects a patient may experience. Now, however, research is starting to mount suggesting whole-plant therapies are more effective than regimens that isolate CBD. A 2015 study conducted by Israeli researchers found that when CBD was isolated, its anti-inflammatory effects were eventually ineffective beyond a certain amount or dose. In contrast, the anti-inflammatory and anti-pain responses experienced from whole-plant CBD were not limited and increased as the dose increased. Many attribute the efficacy of whole-plant cannabis to something called the "entourage effect," which is the synergistic relationship between different cannabinoids and terpenes that enhance the therapeutic potential of cannabis. The researchers explain, "It is likely that other components in the extract synergize with CBD to achieve the desired anti-inflammatory action that may contribute to overcoming the bell-shaped dose-response of purified CBD."
Lawmakers want to limit the THC of cannabis in order to prevent patients from experiencing an unwanted high, but what they don't realize is CBD naturally reduces THC's psychoactive effects while still allowing patients to experience the medical benefits of the cannabinoid. CBD and THC work side by side complementing each other and balancing their analgesic, anti-inflammatory, anti-tumor, and other medically beneficial effects. Like other whole-plant therapies, whole-plant cannabis can hit multiple targets in the body, improve absorption of active ingredients, overcome bacterial defense mechanisms, and minimize adverse side effects.
So that we can better understand the effects of varying cannabinoid compositions in combatting specific symptoms, we kindly remind you to document the percentage of THC and CBD when journaling your medical marijuana regimen. The information on this post has been derived from the Constance Pure Botanical Extract's blog and the study "Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol," and approved by our Chief Medical Officer.